Results 231 to 240 of about 169,803 (413)

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

Angewandte Chemie, EarlyView.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth, Eduard Neu, Davide Provasi, Steffen Feustel, Maximilian F. Schmidt, Harald Hübner, Dorothée Weikert, Marta Filizola, Burkhard König, Peter Gmeiner   +9 more
wiley   +2 more sources

Photoredox‐Autokatalyse: Auf dem Weg zu einer Bibliothek allgemein anwendbarer reduktiver Sulfonamid‐Photokatalysatoren

Angewandte Chemie, EarlyView.
Photoredox‐Autokatalyse ermöglicht den Zugang zu cyclischen Biarylsulfonamiden (BASNs) ohne exogenen Photokatalysator. Neben einem wichtigen Beitrag zur Grundlagenforschung hat die Entdeckung der Photoredox‐Autokatalyse auch zu weiteren praktischen Anwendungen geführt, wie der Entdeckung von BASNs als neuartige, wirksame und leicht zugängliche ...
Jaspreet Kaur, Mark John P. Mandigma, Nakul Abhay Bapat, Joshua P. Barham   +3 more
wiley   +1 more source

“Naked Nickel”‐Catalyzed Heteroaryl–Heteroaryl Suzuki–Miyaura Coupling

Angewandte Chemie, EarlyView.
We report that an air‐stable “naked nickel”, Ni(4‐CF3stb)3, can efficiently catalyze heteroaryl–heteroaryl Suzuki–Miyaura cross‐coupling (SMC) reactions in the absence of exogenous ligands. This protocol permits the construction of >15 different heterobiaryls containing multiple Lewis basic heteroatoms from a broad set of 6‐membered heteroaryl bromides
Rakan Saeb, Byeongdo Roh, Josep Cornella
wiley   +2 more sources

Retraction: Aryl glyoxal: a prime synthetic equivalent for multicomponent reactions in the designing of oxygen heterocycles. [PDF]

RSC Adv
Sheikh AR, Arif A, Khan MM.
europepmc   +1 more source

Kinetics, stoichiometry and mechanism in the bromination of aromatic heterocycles. IV. Aqueous bromination of Imidazo[1,2-a]pyridine [PDF]

, 1974
BE Boulton, B. A. W. Coller
openalex   +1 more source

Approach Toward Stereoselective α‐Arylation by Pd/Cu‐Catalyzed Arylboration of Electron Deficient Alkenes

Angewandte Chemie, EarlyView.
A strategy for the α‐arylation of carbonyl compounds is presented. The Cu‐ and Pd‐catalyzed reaction involves 1,2‐arylboration of electron deficient alkenes and proceeds with high levels of selectivity. The mechanism is addressed and suggests that a boron ligated enolate is responsible for high selectivity.
Suman Das, Maeve A. Reilly, Stanna K. Dorn, Allison M. Pearson, M. Kevin Brown   +4 more
wiley   +2 more sources

Stacking Interactions of Druglike Heterocycles with Nucleobases. [PDF]

J Chem Inf Model
Conner AV, Kim LM, Fagan PA, Harding DP, Wheeler SE.   +4 more
europepmc   +1 more source

Dual‐Responsive Phosphorus‐Based Fluorescent Sensors: Synthesis and Selective Metal Sensing of Pyrazolyl Phosphine Oxides

Angewandte Chemie, EarlyView.
Pyrazolyl phosphine oxides are shown to act as dual‐responsive fluorescent sensors, displaying a selective “turn‐off” fluorescence response for Fe3+ and a “turn‐on” response for Al3+. These systems serve as a new framework in the field of sensing materials based on main‐group elements such as phosphorus. Abstract Despite a wealth of previously reported
Ethan D. E. Calder, Isobel R. J. Hawes, Andrew R. Jupp   +2 more
wiley   +2 more sources

Catalytic Asymmetric Diastereodivergent Synthesis of 2‑Alkenylindoles Bearing both Axial and Central Chirality

Precision Chemistry
Shuang Yang, Jia-Bo Huang, Da-Hua Wang, Ning-Yi Wang, Yu-Yu Chen, Xin-Yan Ke, Hao Chen, Shao-Fei Ni, Yu-Chen Zhang, Feng Shi   +9 more
doaj   +1 more source

Aryl glyoxal: a prime synthetic equivalent for multicomponent reactions in the designing of oxygen heterocycles. [PDF]

RSC Adv
Sheikh AR, Arif A, Khan MM.
europepmc   +1 more source