Results 261 to 270 of about 176,899 (357)

Access to N‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives

open access: yesAngewandte Chemie, EarlyView.
The first general synthetic access to N‐CH₂F and N‐CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds is disclosed. The method involves the direct synthesis of carbamoyl fluoride building blocks from readily available amines, followed by their derivatization. Abstract This work presents the first general synthetic access to
Filip G. Zivkovic   +3 more
wiley   +1 more source

3‐Oxabicyclo[3.1.1]heptane as an Isostere of meta‐Benzene

open access: yesAngewandte Chemie, EarlyView.
3‐Oxabicyclo[3.1.1]heptanes were designed as saturated isosteres of meta‐benzene. Crystallographic analysis revealed that these structures and meta‐benzene have identical geometric properties. Replacement of the central benzene ring in the anticancer drug Sonidegib with 3‐oxabicyclo[3.1.1]heptane provided a patent‐free analogue with a nanomolar potency,
Dmitry Dibchak, Pavel K. Mykhailiuk
wiley   +1 more source

New Heterocyclic Compounds from Oxazol-5(4H)-one and 1,2,4-Triazin-6(5H)-one Classes: Synthesis, Characterization and Toxicity Evaluation. [PDF]

open access: yesMolecules, 2023
Barbuceanu SF   +12 more
europepmc   +1 more source

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