Results 111 to 120 of about 2,253,886 (314)
Discovering Unobserved Heterogeneity in Structural Equation Models to Avert Validity Threats [PDF]
, 2018 A large proportion of information systems research is concerned with developing and testing models pertaining to complex cognition, behaviors, and outcomes of individuals, teams, organizations, and other social systems that are involved in the ...
Ringle, Christian M. +3 more
core
Spatial self-organization of cancer stem cell niches revealed by live single-cell imaging
Stem Cell Research & TherapyBackground Phenotypic plasticity is a major factor in tumor heterogeneity and treatment resistance. In particular, cancer stem cells (CSCs) represent a small subpopulation within tumors that possesses self-renewal and tumor-forming capabilities ...
Mathilde Brulé +12 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Testing heterogeneity within the euro area. [PDF]
This note estimates several constrained versions of an optimization-based multi-country model to test the sources of heterogeneity within the euro area.
Sahuc, J-G., Jondeau, E.
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 1999 The changes in heterogeneity over time and the hierarchical relations existing between a range of spatial scales, studied in a previous work, provided the knowledge and data base for integrated planning at the local scale.
MAIROTA P +2 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Accounting for Heterogeneity in Hedging Behavior: Comparing & Evaluating Grouping Methods [PDF]
Heterogeneity, i.e., the notion that individuals respond differently to economic stimuli, can have profound consequences for the interpretation of behavior and the formulation of agricultural policy.
Pennings, Joost M.E. +2 more
core
Unemployment duration among immigrants and natives: unobserved heterogeneity in a multi-spell duration model [PDF]
, 2008 This paper studies whether the unemployment dynamics of immigrants differ from those of natives, paying special attention to the impact of accounting for unobserved heterogeneity among individuals.
García Pérez, J. Ignacio +3 more
core +1 more source