Results 91 to 100 of about 1,890,045 (316)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Modelling Behavioral Heterogeneity. [PDF]

open access: yes
If one wants to get rid of the paradoxes pointed out by Hildenbrand (1998) and B. de Villemeur (1999), one needs to reformulate Grandmont's (1992) notion of behavioral heterogeneity such as to get exact insensitivity of the aggregate budget share ...
Isabelle MARET, Gael GIRAUD
core  

Imaging Oxygen Distribution in Marine Sediments. The Importance of Bioturbation and Sediment Heterogeneity [PDF]

open access: yes, 2008
The influence of sediment oxygen heterogeneity, due to bioturbation, on diffusive oxygen flux was investigated. Laboratory experiments were carried out with 3 macrobenthic species presenting different bioturbation behaviour patterns:the polychaetes ...
Poggiale, Jean-Christophe   +3 more
core   +1 more source

Induction of AML cell differentiation using HOXA9/DNA binding inhibitors as a potential therapeutic option for HOXA9‐dependent AML

open access: yesHemaSphere
The mainstay of acute myeloid leukemia (AML) treatment still relies on traditional chemotherapy, with a survival rate of approximately 30% for patients under 65 years of age and as low as 5% for those beyond.
Mélanie Lambert   +11 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Unemployment duration among immigrants and natives: unobserved heterogeneity in a multi-spell duration model [PDF]

open access: yes, 2008
This paper studies whether the unemployment dynamics of immigrants differ from those of natives, paying special attention to the impact of accounting for unobserved heterogeneity among individuals.
García Pérez, J. Ignacio   +3 more
core  

Numerical study on surface-heterogeneity-induced anisotropic impact dynamics of droplet [PDF]

open access: yes, 2021
Numerical study on surface-heterogeneity-induced anisotropic impact dynamics of ...
L Jin (7409639), Yuxiang Wang (13100340)
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Heterogeneity and the Voluntary Provision of Public Goods [PDF]

open access: yes
We investigate the effects of heterogeneity, incomplete information and communication on aggregate contributions to a public good using the voluntary contribution mechanism in a nonlinear laboratory environment.
Kenneth S. Chan   +3 more
core  

Firm Heterogeneity and Trade versus Direct Investment Selection [PDF]

open access: yes, 2004
This paper provides a general equilibrium model incorporating firm heterogeneity with the relevance of the distribution of direct investment cost levels.
高木, かおる
core  

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