Results 81 to 90 of about 2,178,756 (313)
Heterogeneous Theories and the Heterogeneous Tool Set
, 2005 Heterogeneous multi-logic theories arise in different contexts: they are needed for the specification of large software systems, as well as for mediating between different ontologies. This is because large theories typically involve different aspects that are best specified in different logics (like equational logics, description logics, first ...
openaire +4 more sources
Modelling Behavioral Heterogeneity. [PDF]
If one wants to get rid of the paradoxes pointed out by Hildenbrand (1998) and B. de Villemeur (1999), one needs to reformulate Grandmont's (1992) notion of behavioral heterogeneity such as to get exact insensitivity of the aggregate budget share ...
Isabelle MARET, Gael GIRAUD
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Emerging roles of MITF as a crucial regulator of immunity
Experimental and Molecular MedicineMicrophthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj +1 more source
, 2019 Heterogeneity may be a most proper word to describe paper and board. Wood, the raw material to produce mechanical pulps, is almost as heterogeneous a material as the products. Looking in a microscope at a mechanical pulp it is obvious that it consists of
Ferritsius, Johanna, +3 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular OncologyAccording to the seed and soil hypothesis, the organ specificity of metastasis is not a random process and depends on multiple tumor‐intrinsic and microenvironmental factors.
Eduardo Candeal +4 more
doaj +1 more source
iScienceSummary: Differential long non-coding RNA (lncRNA) expression has been correlated to clinical characteristics of colorectal cancers (CRCs), which are the second leading cause of cancer-related deaths.
Bernadette Neve +26 more
doaj +1 more source
Fragmentation in heterogeneity-based research: what do we deal with when we deal with heterogeneity?
, 2011 A main assumption of the research in management is the existence of heterogeneity among firms. However, since the first adoption of heterogeneity concept, it has been applied in several managerial fields with different meanings and definitions.
A. Pellegrino, LANZA, ANDREA, G. Simone
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source