Results 81 to 90 of about 1,890,045 (316)

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology
According to the seed and soil hypothesis, the organ specificity of metastasis is not a random process and depends on multiple tumor‐intrinsic and microenvironmental factors.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Heterogeneous Theories and the Heterogeneous Tool Set

, 2005
Heterogeneous multi-logic theories arise in different contexts: they are needed for the specification of large software systems, as well as for mediating between different ontologies. This is because large theories typically involve different aspects that are best specified in different logics (like equational logics, description logics, first ...
openaire   +4 more sources

Emerging roles of MITF as a crucial regulator of immunity

Experimental and Molecular Medicine
Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj   +1 more source

Long non-coding RNA UCA1 modulates SMARCA2-containing SWI/SNF chromatin remodeling complexes in human colorectal cancer

iScience
Summary: Differential long non-coding RNA (lncRNA) expression has been correlated to clinical characteristics of colorectal cancers (CRCs), which are the second leading cause of cancer-related deaths.
Bernadette Neve, Elsa Hadj Bachir, Belinda Duchêne, Mouloud Souidi, Martin Figeac, Jean-Pascal Meneboo, Emmanuelle Leteurtre, Nicolas Jonckheere, Audrey Vincent, Isabelle Van Seuningen, Christophe Mariette, Guillaume Piessen, François Corfiotti, Clarisse Eveno, François-René Pruvot, Stéphanie Truant, Mehdi El Amrani, Emmanuelle Leteurtre, Florence Renaud, Viviane Gnemmi, Laurence Wicquart, Fabienne Escande, Julie Leclerc, Sonia Paget, Soumaya El Moghrabi, Audrey Vincent, Isabelle Van Seuningen   +26 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The effect of aggregation on the magnitude of behavioral heterogeneity. [PDF]

Recent literature has shown that the magnitude of behavioral heterogeneity of a population has an impact on the structure of mean demand. This paper investigates the effect of aggregation on the magnitude of behavioral heterogeneity if we aggregate ...
Ralf Wilke
core  

Consumption inequality and discount rate heterogeneity [PDF]

, 2013
Although standard incomplete market models can account for the magnitude of the rise in consumption inequality over the life cycle, they generate unrealistically concave age profiles of consumption inequality and unrealistically less wealth inequality ...
Sun, Gang
core