Results 71 to 80 of about 3,184,162 (305)

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Heterogeneous Development Graphs and Heterogeneous Borrowing [PDF]

, 2002
Development graphs are a tool for dealing with structured specifications in a formal program development in order to ease the management of change and reusing proofs. Often, different aspects of a software system have to be specified in different logics, since the construction of a huge logic covering all needed features would be too complex to be ...
openaire   +1 more source

Estimating Learning Models with Experimental Data [PDF]

, 2000
We study the statistical properties of three estimation methods for a model of learning that is often tted to experimental data: quadratic deviation measures without unobserved heterogeneity, and maximum likelihood with and without unobserved ...
Cabrales, Antonio, García-Fontes, Walter   +1 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis

Cell Death and Disease
The potential use of pro-senescence therapies, known as TIS (Therapy-Induced Senescence), for the treatment of colorectal cancer (CRC) generated significant interest since they require lower doses compared to those required for inducing apoptosis ...
Ingrid Loison, Adrien Pioger, Sonia Paget, Inès Metatla, OrgaRES Consortium, Audrey Vincent, Corinne Abbadie, Vanessa Dehennaut   +7 more
doaj   +1 more source

Lipid Metabolism and Resistance to Anticancer Treatment

Biology, 2020
Metabolic reprogramming is crucial to respond to cancer cell requirements during tumor development. In the last decade, metabolic alterations have been shown to modulate cancer cells’ sensitivity to chemotherapeutic agents including conventional and ...
Nicolas Germain, Mélanie Dhayer, Marie Boileau, Quentin Fovez, Jerome Kluza, Philippe Marchetti   +5 more
doaj   +1 more source

MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)‐dependent oncogenic driver in vitro and in humanised HGF knock‐in mice

Molecular Oncology, 2023
Exon skipping mutations of the MET receptor tyrosine kinase (METex14), increasingly reported in cancers, occur in 3–4% of non–small‐cell lung cancer (NSCLC). Only 50% of patients have a beneficial response to treatment with MET‐tyrosine kinase inhibitors
Marie Fernandes, Brynna Hoggard, Philippe Jamme, Sonia Paget, Marie‐José Truong, Valérie Grégoire, Audrey Vinchent, Clotilde Descarpentries, Angela Morabito, Justas Stanislovas, Enoir Farage, Jean‐Pascal Meneboo, Shéhérazade Sebda, Katia Bouchekioua‐Bouzaghou, Marie Nollet, Sarah Humez, Timothy Perera, Paul Fromme, Luca Grumolato, Martin Figeac, Marie‐Christine Copin, David Tulasne, Alexis B. Cortot, Stéphanie Kermorgant, Zoulika Kherrouche   +24 more
doaj   +1 more source

Worker heterogeneity, new monopsony, and training [PDF]

, 2007
A worker's output depends not only on his/her own ability but also on that of colleagues, who can facilitate the performance of tasks that each individual cannot accomplish on his/her own.
Barron J. M., Becker G., Booth A. L., Booth A. L., Edwin L., Frank W., Haltiwanger J. C., Hamilton J., Hashimoto M., Hirsch B. T., Kremer M., Lynch L. M., Manning A., Pigou A. C., Sattinger M., Stevens M., Stevens M., Thisse J.-F.   +17 more
core   +2 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source