Results 51 to 60 of about 2,178,756 (313)

Measurement of Heterogeneity in Computational Psychiatry

, 2020
We introduce representational Rényi heterogeneity (RRH), which generalizes existing heterogeneity measurement approaches from ecology (biodiversity measures) and economics (inequality measures).
Nunes, Abraham
core  

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

A coregulatory influence map of glioblastoma heterogeneity and plasticity

npj Precision Oncology
We present GBM-cRegMap, an online resource providing a comprehensive coregulatory influence network perspective on glioblastoma (GBM) heterogeneity and plasticity.
Chloé Bernhard, Konstantinos Geles, Geoffrey Pawlak, Wajdi Dhifli, Aurélien Dispot, Jules Dusol, Maria Kondratova, Sophie Martin, Mélissa Messé, Damien Reita, David Tulasne, Isabelle Van Seuningen, Natacha Entz-Werle, Silvia Anna Ciafrè, Monique Dontenwill, Mohamed Elati   +15 more
doaj   +1 more source

Heterogeneity mapping of protein expression in tumors using quantitative immunofluorescence [PDF]

, 2011
Morphologic heterogeneity within an individual tumor is well-recognized by histopathologists in surgical practice. While this often takes the form of areas of distinct differentiation into recognized histological subtypes, or different pathological grade,
Harrison, David J, Christiansen, Jason, Faratian, Dana, Jones, Christine, Christine Jones, Gustavson, Mark, Scott, Christopher, InHwa Um, Dana Faratian, Jason Christiansen, Mark Gustavson, Christopher Scott, David J. Harrison, Um, InHwa   +13 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Identifying Potent Nonsense-Mediated mRNA Decay Inhibitors with a Novel Screening System

Biomedicines, 2023
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that degrades mRNAs carrying a premature termination codon. Its inhibition, alone or in combination with other approaches, could be exploited to develop therapies for genetic diseases ...
Julie Carrard, Fiona Ratajczak, Joséphine Elsens, Catherine Leroy, Rebekah Kong, Lucie Geoffroy, Arnaud Comte, Guy Fournet, Benoît Joseph, Xiubin Li, Sylvie Moebs-Sanchez, Fabrice Lejeune   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

How to explain the German East–West divide in support of a populist radical right party (AfD): mapping socioeconomic, psychological, and cultural explanatory factors from a demand-side, voter-level perspective

Frontiers in Sociology
IntroductionAlthough the success of the Alternative für Deutschland (AfD) is nationwide, the party received twice as many votes in East compared to West Germany in recent elections.
Hermann Siebel, Gülru Horozoğlu, Ursula Kessels   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: The mechanisms involved in cancer initiation, progression, drug resistance, and disease recurrence are traditionally investigated through in vitro adherent monolayer (2D) cell models.
Camille Jubelin, Camille Jubelin, Camille Jubelin, Javier Muñoz-Garcia, Javier Muñoz-Garcia, Denis Cochonneau, Emilie Ollivier, François Vallette, François Vallette, Marie-Françoise Heymann, Marie-Françoise Heymann, Lisa Oliver, Lisa Oliver, Dominique Heymann, Dominique Heymann, Dominique Heymann   +15 more
doaj   +1 more source