Results 161 to 170 of about 2,178,756 (313)

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Accounting for Geographic Heterogeneity in Recreation Demand Models [PDF]

Spatial differences in site characteristics and user populations may result in heterogeneity of recreation preferences and values across geographic regions.
Bergstrom, John C., Starbuck, C. Meghan, English, Donald B.K., Bowker, James Michael, Sardana, Kavita   +4 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Exploring heterogeneity in mosquito exposure and attraction and its implications for malaria transmission. [PDF]

PLoS Comput Biol
Kamber L, Cavelan A, Penny MA, Chitnis N, Fairbanks EL.   +4 more
europepmc   +1 more source

Ruling out multiplicity and indeterminacy: The role of heterogeneity. [PDF]

It is well known that economies of scale that are external to the individual decision makers can lead to self-fulfilling prophecies and the multiplicity or even indeterminacy of equilibrium. We argue that the importance of this source of multiplicity and
Valentiny, Alos, Waldman, Robert, Herrendorf, Berthold   +2 more
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Exploring Proximal and Distal Ultrasound-Guided Greater Occipital Nerve Block Approaches in Migraine: A Systematic Review and Meta-Analysis. [PDF]

Pain Pract
Sabet H, Samir A, Lashin B, Abbas A, Ramadan S, El-Moslemani M, Younis AF, Yousef O, Rouby RA, Abd-Elsayed A.   +9 more
europepmc   +1 more source

Efficient conjoint choice designs in the presence of respondent heterogeneity. [PDF]

The authors propose a fast and efficient algorithm for constructing D-optimal conjoint choice designs for mixed logit models in the presence of respondent heterogeneity.
Goos, Peter, Vandebroek, Martina, Yu, Jie   +2 more
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interpreting Heterogeneity Beyond I² in Meta-Analysis: Integrating Statistical Metrics With Clinical Judgement. [PDF]

J Eval Clin Pract
Ferreira MHL, Câmara LC, Ferreira FDV, Melo MS, de Souza RF, de Aguiar DR, Pereira SIDS, Junior NC.   +7 more
europepmc   +1 more source