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Heterogeneous views on heterogeneity [PDF]

International Journal of Epidemiology, 2008
The insightful and stimulating commentary by Julian Higgins1 on our paper2 raises several important issues that need to be clarified. First, we need to agree on nomenclature. The heterogeneity literature has been plagued by inconsistent terminology.
Patsopoulos, N. A., Evangelou, E., Ioannidis, J. P. A.   +2 more
openaire   +3 more sources

Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

Frontiers in Endocrinology, 2023
IntroductionReprogramming of cellular metabolism is now a hallmark of tumorigenesis. In recent years, research on pancreatic neuroendocrine tumors (pNETs) has focused on genetic and epigenetic modifications and related signaling pathways, but few studies
Arnaud Jannin, Arnaud Jannin, Anne-Frédérique Dessein, Christine Do Cao, Marie-Christine Vantyghem, Benjamin Chevalier, Isabelle Van Seuningen, Nicolas Jonckheere, Lucie Coppin   +8 more
doaj   +1 more source

Flow Cytometry-based Method for Efficient Sorting of Senescent Cells

Bio-Protocol, 2023
Cellular senescence is a reprogrammed cell state triggered as an adaptative response to a variety of stresses, most often those affecting the genome integrity.
Erwan Goy, Nathalie Martin, Claire Drullion, Laure Saas, Olivier Molendi-Coste, Laurent Pineau, David Dombrowicz, Emeric Deruy, Hélène Bauderlique-Leroy, Olivier Samyn, Joe Nassour, Yvan de Launoit, Corinne Abbadie   +12 more
doaj   +1 more source

A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition

Biomedicine Hub, 2023
Introduction: The quest for small molecule inhibitors of the PD-1/PD-L1 checkpoint continues in parallel to the extensive development of monoclonal antibodies directed against this immune checkpoint. Drug screening strategies are being set up to identify
Xavier Thuru, Romain Magnez, Gérard Vergoten, Christian Bailly   +3 more
doaj   +1 more source

Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA H19

Cells, 2020
Cancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation.
Clément Lecerf, Evodie Peperstraete, Xuefen Le Bourhis, Eric Adriaenssens   +3 more
doaj   +1 more source

Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy

Neoplasia: An International Journal for Oncology Research, 2023
Triple negative breast cancer (TNBC) is an aggressive malignancy for which chemotherapy remains the standard treatment. However, between 3 and 5 years after chemotherapy, about half patients will relapse and it is essential to identify vulnerabilities of
Marie Winter, Amina Nait Eldjoudi, Catherine Guette, Hubert Hondermarck, Roland P. Bourette, Quentin Fovez, William Laine, Bart Ghesquiere, Eric Adriaenssens, Jérôme Kluza, Xuefen Le Bourhis   +10 more
doaj   +1 more source

Hidden allies: how extracellular vesicles drive biofilm formation, stress adaptation, and host–immune interactions in human fungal pathogens

mBio
Pathogenic fungi pose a significant threat to human health, especially given the rising incidence of invasive fungal infections and the emergence of drug-resistant strains.
Philipp Brandt, Rima Singha, Iuliana V. Ene   +2 more
doaj   +1 more source

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +1 more source

Polyoxometalate inhibition of SOX2-mediated tamoxifen resistance in breast cancer

Cell Communication and Signaling
Background Increased cancer stem cell (CSC) content and SOX2 overexpression are common features in the development of resistance to therapy in hormone-dependent breast cancer, which remains an important clinical challenge. SOX2 has potential as biomarker
Iskander Aurrekoetxea-Rodriguez, So Young Lee, Miriam Rábano, Isabel Gris-Cárdenas, Virginia Gamboa-Aldecoa, Irantzu Gorroño, Isabella Ramella-Gal, Connor Parry, Robert M. Kypta, Beñat Artetxe, Juan M. Gutierrez-Zorrilla, Maria dM. Vivanco   +11 more
doaj   +1 more source

Biochemical Characterization of a New Oligoalginate Lyase and Its Biotechnological Application in Laminaria japonica Degradation

Frontiers in Microbiology, 2020
Oligoalginate lyases catalyze the degradation of alginate polymers and oligomers into monomers, a prerequisite for biotechnological utilizing alginate.
Shangyong Li, Shangyong Li, Linna Wang, Samil Jung, Beom Suk Lee, Ningning He, Myeong-Sok Lee   +6 more
doaj   +1 more source