Results 31 to 40 of about 3,130,844 (307)

Measurement of Protein-Protein Interactions through Microscale Thermophoresis (MST)

Bio-Protocol, 2020
The binding interactions of PD-1 and PD-L1 have been studied by surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) over the past few years, but these investigations resulted in controversy regarding the values of the dissociation ...
Magnez Romain, Bryan Thiroux, Morgane Tardy, Bruno Quesnel, Xavier Thuru   +4 more
doaj   +1 more source

Analyses of natural courses of Japanese patients with Alzheimer's disease using placebo data from placebo‐controlled, randomized clinical trials: Japanese Study on the Estimation of Clinical course of Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019
Introduction Symptomatic anti‐Alzheimer's disease (AD) drugs have been commonly used for the treatment of AD. Knowing the natural courses of patients with AD on placebo is highly relevant for clinicians to understand their efficacy and for investigators ...
Mitsunori Watanabe, Yu Nakamura, Yasumasa Yoshiyama, Tatsuo Kagimura, Hiroyuki Kawaguchi, Hiroshi Matsuzawa, Yosuke Tachibana, Kazuma Nishimura, Naoki Kubota, Masato Kobayashi, Takayuki Saito, Kaoru Tamura, Takayuki Sato, Masayoshi Takahashi, Japanese Society of Scaling Keys of Evaluation Techniques for CNS Disorders Heterogeneity (SKETCH) study group, Akira Homma   +15 more
doaj   +1 more source

Influence of EGF and pro-NGF on EGFR/SORTILIN interaction and clinical impact in head and neck squamous cell carcinoma

Frontiers in Oncology, 2023
Head and Neck Squamous Cell Carcinoma (HNSCC) remains a cancer with a poor prognosis, with a 5-year survival rate of less than 50%. Although epidermal growth factor receptor (EGFR) is almost always overexpressed, targeted anti-EGFR therapies have modest ...
Martin Morisse, Martin Morisse, Thomas Bourhis, Thomas Bourhis, Romain Lévêque, Mathieu Guilbert, Julien Cicero, Martine Palma, Dominique Chevalier, Dominique Chevalier, Xuefen le Bourhis, Robert-Alain Toillon, Francois Mouawad, Francois Mouawad   +13 more
doaj   +1 more source

A Bayesian spatial random effects model characterisation of tumour heterogeneity implemented using Markov chain Monte Carlo (MCMC) simulation [PDF]

, 2016
The focus of this study is the development of a statistical modelling procedure for characterising intra-tumour heterogeneity, motivated by recent clinical literature indicating that a variety of tumours exhibit a considerable degree of genetic spatial ...
Grech-Sollars, M, King, MD
core   +1 more source

Heterogeneous views on heterogeneity [PDF]

International Journal of Epidemiology, 2008
The insightful and stimulating commentary by Julian Higgins1 on our paper2 raises several important issues that need to be clarified. First, we need to agree on nomenclature. The heterogeneity literature has been plagued by inconsistent terminology.
Patsopoulos, N. A., Evangelou, E., Ioannidis, J. P. A.   +2 more
openaire   +3 more sources

Dynamic heterogeneity in amorphous materials [PDF]

, 2010
Amorphous solids are mechanically rigid while possessing a disordered structure similar to that of dense liquids. Recent research indicates that dynamical heterogeneity, spatio-temporal fluctuations in local dynamical behavior, might help understanding ...
L. Berthier, Ludovic Berthier, W. Götze
core   +1 more source

Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

Frontiers in Endocrinology, 2023
IntroductionReprogramming of cellular metabolism is now a hallmark of tumorigenesis. In recent years, research on pancreatic neuroendocrine tumors (pNETs) has focused on genetic and epigenetic modifications and related signaling pathways, but few studies
Arnaud Jannin, Arnaud Jannin, Anne-Frédérique Dessein, Christine Do Cao, Marie-Christine Vantyghem, Benjamin Chevalier, Isabelle Van Seuningen, Nicolas Jonckheere, Lucie Coppin   +8 more
doaj   +1 more source

A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint Inhibition

Biomedicine Hub, 2023
Introduction: The quest for small molecule inhibitors of the PD-1/PD-L1 checkpoint continues in parallel to the extensive development of monoclonal antibodies directed against this immune checkpoint. Drug screening strategies are being set up to identify
Xavier Thuru, Romain Magnez, Gérard Vergoten, Christian Bailly   +3 more
doaj   +1 more source

Prominent effect of soil network heterogeneity on microbial invasion [PDF]

, 2012
Using a network representation for real soil samples and mathematical models for microbial spread, we show that the structural heterogeneity of the soil habitat may have a very significant influence on the size of microbial invasions of the soil pore ...
Costa, Luciano da F., Gilligan, Christopher A., Otten, Wilfred, Perez-Reche, Francisco J., Taraskin, Sergei N., Viana, M. P.   +5 more
core   +4 more sources

Flow Cytometry-based Method for Efficient Sorting of Senescent Cells

Bio-Protocol, 2023
Cellular senescence is a reprogrammed cell state triggered as an adaptative response to a variety of stresses, most often those affecting the genome integrity.
Erwan Goy, Nathalie Martin, Claire Drullion, Laure Saas, Olivier Molendi-Coste, Laurent Pineau, David Dombrowicz, Emeric Deruy, Hélène Bauderlique-Leroy, Olivier Samyn, Joe Nassour, Yvan de Launoit, Corinne Abbadie   +12 more
doaj   +1 more source