Results 141 to 150 of about 348,200 (357)

In Vivo Biosynthesis and Direct Incorporation of Non‐Canonical Amino Acids into Proteins

ChemBioChem, Accepted Article.
Autonomous cells are engineered biological systems capable of biosynthesising and directly incorporating non‐canonical amino acids (ncAAs) into proteins. These systems have the potential to extend the applicability of the genetic code to enable large‐scale fermentative production of proteins carrying ncAAs.
Ivana Drienovska, Jan Hendrik Illies, T. Moritz Weber   +2 more
wiley   +1 more source

Identification of a l‐Threonine‐Utilizing Hydrazine Synthetase for Thrazarine Biosynthesis in Streptomyces coerulescens MH802‐fF5

ChemBioChem, EarlyView.
A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai, Hideyuki Muramatsu, Masayuki Igarashi, Yohei Katsuyama, Yasuo Ohnishi   +4 more
wiley   +1 more source

STUDIES ON CROSS-REACTIVITY OF ANTIRIBONUCLEASE ANTISERA WITH HETEROLOGOUS MAMMALIAN RIBONUCLEASES [PDF]

, 1968
Shigeru Morikawa, Masao Yamamura, Takayuki Harada, Yoshihiro Hamashima   +3 more
openalex   +1 more source

Dominant‐Negative Effects of p53 R337 Variants in Li–Fraumeni Syndrome: Impact on Tetramer Formation and Transcriptional Activity

ChemBioChem, EarlyView.
Hetero‐tetramer dysfunction: Li–Fraumeni syndrome (LFS) is a hereditary cancer predisposition caused by mutations in the TP53 gene encoding the tumor suppressor p53. It is shown that p53 variants R337C and R337H, found in LFS, impair wild‐type (WT) p53 function by forming heterotetramers with reduced transcriptional activity.
Rui Kamada, Shuya Sakaguchi, Madoka Kanno, Takaaki Ozawa, Natsumi Nakagawa, James G. Omichinski, Kazuyasu Sakaguchi   +6 more
wiley   +1 more source

The Rarity in the Rarity: Presentation of Three Cases of Cutaneous Carcinosarcoma with Clinical and Histopathological Insights

Dermatopathology
A cutaneous carcinosarcoma (cCS) is a rare and aggressive skin cancer characterized by both carcinomatous (epithelial) and sarcomatous (mesenchymal) components, making it a biphasic tumor.
Gerardo Cazzato, Anna Colagrande, Valentina Caputo, Giuseppe Ingravallo, Eliano Cascardi, Francesco Fortarezza, Emanuela Bonoldi, Franco Rongioletti   +7 more
doaj   +1 more source

Heterologous Aortic Grafts–With Special Reference to Recipient Site, Ethylene Oxide Freeze-dry Preparation and Species of Origin

, 1957
Sidmund A. Wesolowski, Lester R. Sauvage
openalex   +2 more sources

Critical Variables of the Jerne Plaque Technique As Applied to Rodent Antibody-Forming Systems Responding to Heterologous Red Cell Antigens [PDF]

, 1969
Karl F. Hübner, N. Gengozian
openalex   +1 more source

Identification of Pyrrolizilactone Biosynthetic Gene Cluster with Unique Short‐Chain Dehydrogenase Gene for 3‐Methylproline Formation

ChemistryEurope, EarlyView.
A standalone enzyme, derived from the reductase domain of a polyketide synthase‐nonribosomal peptide synthetase hybrid enzyme, is identified as a pyrroline carboxylate reductase. This enzyme is involved in the biosynthesis of 3‐methylproline, an amino acid building block of a unique tricyclic pyrrolizidinone structure of a fungal metabolite ...
Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Tohru Taniguchi, Hiroyuki Osada, Shunji Takahashi   +6 more
wiley   +1 more source

Antibody Responses in Rabbits to the Group B Arbovirus Kunjin: Serologic Activity of the Fractionated Immunoglobulins in Homologous and Heterologous Reactions [PDF]

, 1968
E. G. Westaway
openalex   +1 more source

A sensitive assay reveals structural requirements for α-synuclein fibril growth [PDF]

, 2017
Bagchi, Devika P, Dhavale, Dhruva D, Engel, Laura A, Kotzbauer, Paul T, Sarezky, Jonathan, Tsai, Christina   +5 more
core   +2 more sources