Results 151 to 160 of about 440,074 (404)
Applied Microbiology and Biotechnology, 2014 Pichia pastoris is an established protein expression host mainly applied for the production of biopharmaceuticals and industrial enzymes. This methylotrophic yeast is a distinguished production system for its growth to very high cell densities, for the ...
Mudassar Ahmad +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang +10 more
wiley +1 more source
Angewandte Chemie, EarlyView.Catalytic aerobic oxidation under aqueous alkaline conditions promotes C–C cleavage in pine‐ and poplar‐derived lignin oligomers, accessing high yields of aromatic monomers. The monomeric phenols obtained from this process then undergo effective biological conversion into cis,cis‐muconic acid and 2‐pyrone‐4,6‐dicarboxylic acid using engineered strains ...
Surajudeen Omolabake +7 more
wiley +2 more sources
Advanced Science, EarlyView.Schematic overview of PROTAC‐enhanced chemo‐metalloimmunotherapy, integrating senescence induction, multi‐modal STING pathway activation, PD‐L1 blockade, and immune amplification via coordinated PROTACs, metal ions, and chemotherapy to elicit robust antitumor immunity and circumvent immune evasion.
Zhenzhen Chen +3 more
wiley +1 more source
Inactivation of the Burkholderia Toxin Malleicyprol by Enzymatic Cyclopropanol Ring Opening
Angewandte Chemie, EarlyView.Burkholderia pseudomallei and Burkholderia mallei are dangerous pathogens that cause severe diseases with high mortality rates. Their virulence relies in part on malleicyprols, potent toxins containing a highly reactive cyclopropanol group. In this study, we identify BurK, a heme‐dependent oxidoreductase that neutralizes malleicyprols by enzymatically ...
Jonas Fiedler +4 more
wiley +2 more sources
Advanced Science, EarlyView.Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang +13 more
wiley +1 more source
Advanced Science, EarlyView.Schematic overview illustrating the detrimental role of gut microbiota in aspirin‐induced intestinal injury. L. sphaericus and its secreted carboxylesterase EstB are identified as key drivers that catalyze aspirin hydrolysis into salicylic acid, thereby exacerbating intestinal injury. Inhibition of EstB by the dietary compound flavanomarein effectively
Zeyu Zhao +13 more
wiley +1 more source
Insights on cytotoxic cells of the colonial ascidian Botryllus schlosseri [PDF]
, 2015 Morula cells (MCs) represent the most abundant circulating hemocyte of the compound ascidian Botryllus schlosseri. They are cytotoxic cells involved in the rejection reaction between contacting, genetically incompatible colonies.
Ballarin, Loriano +2 more
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