Results 171 to 180 of about 440,074 (404)

A sensitive assay reveals structural requirements for α-synuclein fibril growth [PDF]

open access: yes, 2017
Bagchi, Devika P   +5 more
core   +2 more sources

Homoterpene Biosynthesis in Fungi

open access: yesAngewandte Chemie International Edition, EarlyView.
The first homoterpene biosynthetic pathway in the fungal kingdom is reported. A methyltransferase–terpene cyclase pair produces a unique heptamethyl bicyclo[3.3.1]nonane homoterpene via presodorifen, demonstrating that homoterpene biosynthesis via the addition of a C1 unit to terpene diphosphate precursors prior to scaffold formation extends beyond the
Lin Zhou   +5 more
wiley   +1 more source

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons. [PDF]

open access: yes, 2019
Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications.
Dong, Jie-Xian   +11 more
core  

Heterologous SARS-CoV-2 Buccal Immunization with Oral Dissolving Films Generated a Strong Systemic and Mucosal Immunity in a Murine Model

open access: yesVaccines
Background: In response to the emergence of immune-evasive variants of SARS-CoV-2, this study explores a novel heterologous vaccination strategy using a microparticulate formulation approach that is delivered via oral dissolving film (ODF) formulations ...
Tanisha Manoj Arte   +8 more
doaj   +1 more source

HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Anti‐citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among RA patients, including for motif‐containing epitopes in important self‐antigens like collagen ...
S. Janna Bashar   +4 more
wiley   +1 more source

Industrial strategies to minimize glycerol formation in ethanol fermentation by conventional Saccharomyces cerevisiae

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract Industrial ethanol production faces the challenge of balancing metabolic efficiency with the minimization of byproducts such as glycerol, whose formation is intensified by osmotic, thermal, oxidative, and nutritional stresses. In the literature, two main approaches stand out for modulating its synthesis: the use of genetically modified strains
Lorena M. F. Leite   +2 more
wiley   +1 more source

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