Results 31 to 40 of about 440,074 (404)

Heterologous prime-boost: breaking the protective immune response bottleneck of COVID-19 vaccine candidates

Emerging Microbes and Infections, 2021
COVID-19 vaccines emerging from different platforms differ in efficacy, duration of protection, and side effects. To maximize the benefits of vaccination, we explored the utility of employing a heterologous prime-boost strategy in which different ...
Qian He, Qunying Mao, Chaoqiang An, Jialu Zhang, Fan Gao, Lian-lian Bian, Changgui Li, Zhenglun Liang, Miao Xu, Junzhi Wang   +9 more
semanticscholar   +1 more source

A sigma factor toolbox for orthogonal gene expression in Escherichia coli [PDF]

, 2018
Synthetic genetic sensors and circuits enable programmable control over timing and conditions of gene expression and, as a result, are increasingly incorporated into the control of complex and multi-gene pathways.
Bervoets, Indra, Charlier, Daniel, De Mey, Marjan, Maertens, Jo, Van Brempt, Maarten, Van Hove, Bob, Van Nerom, Katleen   +6 more
core   +4 more sources

The Pilot Study of Immunogenicity and Adverse Events of a COVID-19 Vaccine Regimen: Priming with Inactivated Whole SARS-CoV-2 Vaccine (CoronaVac) and Boosting with the Adenoviral Vector (ChAdOx1 nCoV-19) Vaccine

Vaccines, 2022
In response to the SARS-CoV-2 Delta variant, which partially escaped the vaccine-induced immunity provided by two doses of vaccination with CoronaVac (Sinovac), the National Vaccine Committee recommended the heterologous CoronaVac-ChAdOx1 (Oxford ...
Surakameth Mahasirimongkol, Athiwat Khunphon, Oraya Kwangsukstid, Sompong Sapsutthipas, Mingkwan Wichaidit, Archawin Rojanawiwat, Nuanjun Wichuckchinda, Wiroj Puangtubtim, Warangluk Pimpapai, Sakulrat Soonthorncharttrawat, Asawin Wanitchang, Anan Jongkaewwattana, Kanjana Srisutthisamphan, Daraka Phainupong, Naphatcha Thawong, Pundharika Piboonsiri, Waritta Sawaengdee, Thitiporn Somsaard, Kanokphon Ritthitham, Supaporn Chumpol, Nadthanan Pinyosukhee, Rattanawadee Wichajarn, Panadda Dhepakson, Sopon Iamsirithaworn, Supaporn Phumiamorn   +24 more
doaj   +1 more source

Heterologous carriers in the anamnestic antihapten response [PDF]

, 1968
Anamnestic antihapten responses were obtained to trinitrophenyl (TNP) when rabbits sensitized to trinitrophenyl-hemocyanin (TNP-KLH) were challenged with TNP-heterologous protein conjugates.
Campbell, Dan H., Rittenberg, Marvin B.
core   +2 more sources

Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition – A Nested Case-Control Study in HIV-1 Serodiscordant Couples

Frontiers in Immunology, 2022
Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope.
Melinda S. Suchard, Melinda S. Suchard, Neil Martinson, Neil Martinson, Susan Malfeld, Debbie de Assis Rosa, Romel D. Mackelprang, Romel D. Mackelprang, Jairam Lingappa, Jairam Lingappa, Xuanlin Hou, Helen Rees, Sinead Delany-Moretlwe, Hadassa Goldfein, Heena Ranchod, Heena Ranchod, David Coetzee, Kennedy Otwombe, Kennedy Otwombe, Lynn Morris, Lynn Morris, Caroline T. Tiemessen, Caroline T. Tiemessen, Dana M. Savulescu   +23 more
doaj   +1 more source

Heterologous vaccination regimens with self-amplifying RNA and adenoviral COVID vaccines induce robust immune responses in mice

Nature Communications, 2021
Several vaccines have demonstrated efficacy against SARS-CoV-2 mediated disease, yet there is limited data on the immune response induced by heterologous vaccination regimens using alternate vaccine modalities.
Alexandra J. Spencer, P. McKay, Sandra Belij-Rammerstorfer, M. Ulaszewska, Cameron Bissett, Kai Hu, K. Samnuan, A. Blakney, D. Wright, H. Sharpe, Ciarán Gilbride, Adam Truby, E. Allen, S. Gilbert, R. Shattock, T. Lambe   +15 more
semanticscholar   +1 more source

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

Science, 2021
Description Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history.
C. Reynolds, J. Gibbons, C. Pade, Kai-Min Lin, Diana Mūnoz Sandoval, F. Pieper, D. Butler, Siyi Liu, A. Otter, G. Joy, K. Menacho, M. Fontana, A. Smit, B. Kele, T. Cutino-Moguel, M. Maini, M. Noursadeghi, T. Brooks, A. Semper, C. Manisty, T. Treibel, J. Moon, Á. McKnight, D. Altmann, R. Boyton   +24 more
semanticscholar   +1 more source

Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity

medRxiv, 2021
Background Heterologous prime-boost schedules with vector- and mRNA-based COVID-19 vaccines are already administered, but immunological responses and elicited protection have not been reported.
R. Gross, M. Zanoni, Alina Seidel, Carina Conzelmann, Andrea Gilg, Daniela Krnavek, Sümeyye Erdemci-Evin, Benjamin Mayer, M. Hoffmann, S. Pöhlmann, Alexandra Beil, J. Kroschel, B. Jahrsdörfer, H. Schrezenmeier, F. Kirchhoff, J. Münch, Janis A. Müller   +16 more
semanticscholar   +1 more source

Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya [PDF]

, 2012
Background: Respiratory syncytial virus (RSV) reinfects individuals repeatedly. The extent to which this is a consequence of RSV antigenic diversity is unclear.
Alexander G. Mwihuri, Anderson, Cane, Cane, Cane, Cane, Cane, Charles J. Sande, Charles N. Agoti, Choi, Clayton O. Onyango, Collins, D. James Nokes, Falsey, Falsey, Glezen, Graham F. Medley, Gunson, Hall, Hall, Hall, Henderson, Johnson, Johnson, Melero, Mufson, Mufson, Nair, Nokes, Nokes, Ohuma, Okiro, Parveen, Patricia A. Cane, Peret, Peret, Posada, Sande, Scott, Sullender, Sullender, Tamura, Trento, Trento, Trento, Venter, Waris, White, Xia, Yamaguchi, Zlateva   +50 more
core   +1 more source

Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients

JAMA Internal Medicine, 2021
Key Points Question Does a heterologous SARS-CoV-2 vaccination strategy with the vector vaccine Ad26COVS1 result in a higher rate of antibody response compared with a homologous third dose of mRNA vaccine (mRNA-1273 or BNT162b2) in kidney transplant ...
R. Reindl-Schwaighofer, A. Heinzel, M. Mayrdorfer, Rhea Jabbour, T. Hofbauer, A. Merrelaar, M. Eder, Florina Regele, Konstantin Doberer, Paul Spechtl, C. Aschauer, M. Koblischke, C. Paschen, F. Eskandary, Karin Hu, Barbara Öhler, Arshdeep Bhandal, Sabine Kleibenböck, Rahel Jagoditsch, Bianca Reiskopf, F. Heger, G. Bond, G. Böhmig, R. Strassl, L. Weseslindtner, A. Indra, J. Aberle, Michael Binder, R. Oberbauer   +28 more
semanticscholar   +1 more source