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Expression of Heterologous Genes
1991With the advent of recombinant DNA technology in the mid-1970s a number of shrewd academics quickly realized the commercial potential of these tools in producing proteins of high commercial value, which, until that time, had proven both difficult and expensive to isolate in quantities sufficient for clinical trials.
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Glucose Uptake in Heterologous Expression Systems
2017Understanding the physiological regulation of glucose transport requires the analysis of transporters, like GLUT1, in diverse tissue types. We document the utility of viral vectors for the stable expression of wild-type and modified GLUT1 transporter in different types of mammalian cells.
Eunice E, Lee, Richard C, Wang
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Heterologous expression systems for polyketide synthases
Nat. Prod. Rep., 2009Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs.
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Sarcoglycan heterologous expression.
2004Mutations in sarcoglycans (SGs) cause autosomal-recessive limb-girdle muscular dystrophy. SGs exist as a complex of four transmembrane proteins (a, b, c, and d). We have recently shown that a-SG is an ecto-ATPase, i.e. an enzyme able to hydrolyze extracellular ATP.
GASTALDELLO S +9 more
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Advances in heterologous gene expression by Streptomyces
Current Opinion in Biotechnology, 1994During the past year, noteworthy advances have been made in our ability to express foreign genes in Streptomyces. These advances were due, in part, to a detailed examination of the critical parameters that limit expression by Streptomyces of soluble forms of the human T-cell receptor CD4.
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Heterologous expression of calcium channels
The Journal of Membrane Biology, 1992J, Nargeot, N, Dascal, H A, Lester
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Heterologous Expression Systems for Lipases: A Review
2012The production of heterologous lipases is one of the most promising strategies to increase the productivity of the bioprocesses and to reduce costs, with the final objective that more industrial lipase applications could be implemented. In this chapter, an overview of the most common microbial expression systems for the overproduction of microbial ...
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Understanding bacteriocin heterologous expression: A review
International Journal of Biological MacromoleculesBacteriocins are a diverse group of ribosomally synthesised antimicrobial peptides/proteins that play an important role in self-defence. They are widely used as bio-preservatives and effective substitutes for disease eradication. They can be used in conjunction with or as an alternative to antibiotics to minimize the risk of resistance development ...
Priyanshi M, Jain +2 more
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