Results 211 to 220 of about 3,478,631 (289)

Heterologous expression of interferon-stimulated genes reveals conserved anti-<i>Toxoplasma</i> properties between human and porcine cells. [PDF]

Front Immunol
Ungogo MA, Chandrasegaran PRG, Khalid H, Powell J, Jamil H, Grey F, Hassan MA.   +6 more
europepmc   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Heterologous expression of a heme-dependent catalase from Avicennia marina confers multi-stress tolerance in Escherichia coli for biotechnological applications. [PDF]

Sci Rep
Shahpiri A, Rafiei M, Sharafi SM.
europepmc   +1 more source

Xenopus oocytes as a heterologous expression system for plant proteins

, 1995
Theodoulou, F. L., Miller, A. J., Anthony J. Miller, Frederica L. Theodoulou   +3 more
core   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Co-Cultivation of Cross-Kingdom Microorganisms Effectively Triggers the Production of Tryptophol and Its Heterologous Expression in <i>E. coli</i>. [PDF]

Microorganisms
Li Y, Xia X, Ren J, Tan H, Li J.
europepmc   +1 more source

Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense

New Plant Protection, EarlyView.
Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley   +1 more source

Heterologous expression of a cold-active small esterolytic enzyme from <i>Pseudomonas sivasensis</i> R11S16 and its potential for azithromycin removal. [PDF]

3 Biotech
Çon G, Karakaya E, Saygin H, Saricaoğlu S, Könen Adıgüzel S, Adıgüzel AO.   +5 more
europepmc   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

Developing an <i>E. coli</i> heterologous expression system for characterizing a marine debrominase from <i>Roseobacter</i> sp. [PDF]

Appl Environ Microbiol
Li X, Yang S, Liu Y, Huang H, Zhang X, Zhong Y, Adrian L, Peng P.   +7 more
europepmc   +1 more source