Results 141 to 150 of about 49,719 (277)

Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.

, 2016
Adenoviruses (Ad) are commonly used as vectors for gene therapy and/or vaccine delivery. Recombinant Ad vectors are being tested as vaccines for many pathogens.
Rakesh Kumar, Subodh Kumar Samrat, Shakti Singh (515117), Subodh Kumar Samrat (515116), Babita Agrawal (241460), Rakesh Kumar (8432), Wen Li (143214), Shakti Singh, Babita Agrawal, Wen Li, Satish Vedi, Satish Vedi (844747)   +11 more
core   +1 more source

Navigating Oral Food Challenges in Clinical Trials to Keep the Science Moving Forward

Allergy, EarlyView.
ABSTRACT The oral food challenge (OFC) has long been the reference standard for food allergy diagnosis, as well as to confirm natural development of oral tolerance. The utilization of OFCs has significantly broadened from its role in defining disease to defining participant eligibility, individual allergen reactivity thresholds and treatment outcomes ...
Edwin H. Kim, J. Andrew Bird, Helen A. Brough, David M. Fleischer, Stacie M. Jones, Ildiko Kun, Wayne Shreffler, Claire Van Eenwyk, Brian P. Vickery, Julie Wang, Alexandra F. Santos   +10 more
wiley   +1 more source

Distinct humoral responses induced by heterologous versus homologous prime–boost immunization strategies in early life

Frontiers in Immunology
An important component in the development of efficacious vaccines is the optimization of vaccination schedules to elicit protective immunity, especially in a vulnerable group like infants.
Poorya Foroutan Pajoohian, Poorya Foroutan Pajoohian, Audur Anna Aradottir Pind, Audur Anna Aradottir Pind, Jenny Lorena Molina Estupiñan, Jenny Lorena Molina Estupiñan, Dennis Christensen, Gabriel Kristian Pedersen, Thorunn A. Olafsdottir, Ingileif Jonsdottir, Stefania P. Bjarnarson, Stefania P. Bjarnarson   +11 more
doaj   +1 more source

IgE Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges

Allergy, EarlyView.
MAT is dependent on the presence of allergen‐specific IgE and can provide false‐negative results in allergic patients with low allergen‐specific IgE levels. MAT and BAT are moderately correlated. MAT can be used as a surrogate of BAT, when fresh blood is not available or in the case of patients with non‐releaser basophils.
Vikki Houghton, Vasco Claro, Nur Romli, Zainab Jama, Grammatiki Antoneria, Matthew Kwok, Alexandra F. Santos   +6 more
wiley   +1 more source

BCG-associated heterologous immunity, a historical perspective: intervention studies in animal models of infectious diseases.

, 2015
The WHO Special Advisory Group of Experts (SAGE) review of the available epidemiological and trial evidence in humans concluded that bacillus Calmette-Guérin (BCG) vaccination leads to beneficial heterologous ('non-specific') effects, specifically on all-
B. Freyne, A. Marchant, N. Curtis, Freyne, Bridget, Marchant, Arnaud, Curtis, Nigel   +5 more
core   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, EarlyView.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Broadening SARS-CoV-2 Immunity by Combining ORFV and Protein-Based Vaccines

Vaccines
Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection.
Alena Reguzova, Melanie Müller, Madeleine Fandrich, Alex Dulovic, Ralf Amann   +4 more
doaj   +1 more source

Immune System Development—Pro Tips for Paediatricians

Acta Paediatrica, EarlyView.
ABSTRACT There are many misconceptions about the immune system in children, its impact on infectious disease susceptibility and its role in the rapidly increasing rates of immune mediated diseases in industrialized societies. In this mini review, I will discuss common believes and the data supporting or countering such believes, with a focus on ...
Petter Brodin
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation

, 2014
The immune response to an infection is determined by a number of factors, which also affect the generation of memory T cells afterwards. The immune response can also affect the stability of the pre-existing memory populations.
Che, Jenny Wun-Yue
core   +1 more source