Results 141 to 150 of about 48,636 (248)

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Engineering Antibody Evolution: Germline‐Targeting HIV Vaccines Reach a Turning Point

Immunology &Cell Biology, EarlyView.
This commentary examines three recent Nature studies demonstrating a conceptual shift in HIV vaccine design, demonstrating how germline‐targeting HIV vaccines can progress beyond expanding rare broad neutralizing antibody (bnAb) precursors to deliberately guiding their affinity maturation into bnAbs in non‐human primates.
Rowena A. Bull, Deborah L. Burnett
wiley   +1 more source

The Improvement of Adaptive Immune Responses towards COVID-19 Following Diphtheria-Tetanus-Pertussis and SARS-CoV-2 Vaccinations in Indonesian Children: Exploring the Roles of Heterologous Immunity. [PDF]

Vaccines (Basel)
Santi T, Jo J, Harahap AR, Werdhani RA, Hadinegoro SRS, SahBandar IN, Prayitno A, Munasir Z, Vandenplas Y, Hegar B.   +9 more
europepmc   +1 more source

Immunogenicity and Protective Efficacy of the First Autogenous Aeromonas hydrophila Vaccine for Piaractus brachypomus

Journal of Fish Diseases, EarlyView.
ABSTRACT Aeromonas hydrophila is a major zoonotic bacterial pathogen responsible for haemorrhagic septicemia, substantial economic losses in aquaculture and increasing antimicrobial resistance among field isolates. It is also one of the main bacterial species associated with mortality outbreaks in pirapitinga, Piaractus brachypomus, culture in the ...
Layana Aparecida Batista Pereira, Juliana do Nascimento Ferreira, Laine Patricia Costa dos Santos, Larissa Andréia Ferreira Sampaio, Igor Bartolomeu Alves de Barros, Elizabeth Gusmão Affonso, Jefferson Yunis‐Aguinaga, Gustavo da Silva Claudiano   +7 more
wiley   +1 more source

Light signaling controls chloroplast pyruvate metabolism through the STF1/2–PKP1 module in soybean

Journal of Integrative Plant Biology, EarlyView.
In soybean, light‐responsive proteins switch on GmPKP1, which boosts chloroplast pyruvate production. This increases pigments, photosynthesis, seed oil, pod number, and yield, revealing a new way that light boosts crop productivity. ABSTRACT Light signaling coordinates plant development with metabolism, but the link between photoreceptors and ...
Faming Lin, Xiaoran Wang, Chenhao Zhao, Shaolong Yang, Jingnan Xu, Hongyi Su, Ruixiang Lei, Yilei Xu, Jike Xue, Ming Chang, Fanjiang Kong, Ran Wang   +11 more
wiley   +1 more source

Archaeal Genes Code for GGDEF Domain Proteins With Diguanylate Cyclase Activity

Molecular Microbiology, EarlyView.
A biofilm‐like mode of growth is hypothesized to be required for the emergence of cellular life. Occurrence of common biofilm gene products in current Bacteria and Archaea is an indication for their previous presence in the last universal common ancestor LUCA and perhaps even in the first universal common ancestor FUCA.
Roman Sidorov, Li Li, Ali Dadvar, Irfan Ahmad, Stefan Spring, Jörg Overmann, Ute Römling   +6 more
wiley   +1 more source

TurboID‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

New Phytologist, EarlyView.
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1‐interacting proteins upon different metal regimes. Among validated candidates, the endosome‐localized NHX5 Na+ (K+)/H+ antiporter and the plasma membrane ...
Liza Pellegrin, Steven Fanara, Bertrand Fabre, Carole Pichereaux, Nathalie Leonhardt, Valérie Cotelle, Grégory Vert, Julie Neveu   +7 more
wiley   +1 more source

Differential ubiquitin modifications of ESCRT‐I subunits VPS37‐1 and VPS28‐2 positively regulate plant immunity

New Phytologist, EarlyView.
The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2‐mediated plant immunity against bacterial pathogens by modifying the ESCRT‐I subunits VPS28‐2 and VPS37‐1 with distinct ubiquitin chain types. Summary Sensing of pathogen‐associated molecular patterns (PAMPs) by pattern recognition receptors at the cell surface initiates the first
Chaofeng Wang, Yi Zhang, Bangjun Zhou, Pooja Verma, Lirong Zeng   +4 more
wiley   +1 more source

Maturation-Dependent Constraints in the Ability of Human Monocytes to Initiate Trained Immunity. [PDF]

MedComm (2020)
In premature infants, innate immune memory may serve as an important compensatory mechanism for the underdeveloped adaptive immune system. However, monocytes derived from prematurely born individuals display abnormal metabolic and insufficient transcriptomic responses to β‐glucan‐induced training.
Eigenschink M, Davogg E, Pristner M, Seki D, Arzmüller M, Kiss H, Farr A, Berger A, Berry D, Warth B, Wisgrill L.   +10 more
europepmc   +2 more sources