Enhancing tuberculosis vaccine efficacy with a heterologous mRNA-ChAdOx1 prime-pull strategy targeting lung-resident memory T cells. [PDF]
Korompis M +5 more
europepmc +1 more source
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley +1 more source
Editorial: Vaccines and molecular therapeutics for tuberculosis. [PDF]
Sable SB, Velu V, Kupz A.
europepmc +1 more source
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao +15 more
wiley +1 more source
Dual induction of tissue-resident T and B cell immunity for broad influenza protection with a nanofiber-VLP vaccine. [PDF]
Wang X +15 more
europepmc +1 more source
ABSTRACT Background The role of bone grafting in subtalar joint arthrodesis (SJA) remains controversial. This study aimed to compare clinical and radiographic outcomes of SJA performed with and without bone graft and to evaluate the influence of different graft types on fusion and functional results.
Giovan Giuseppe Mazzella +11 more
wiley +1 more source
Hybrid and Vaccine-Induced Immunity Against SARS-CoV-2 in a Cohort of Hospitalized Patients from the Metropolitan Aburrá Valley, Colombia. [PDF]
Hernández-Ortiz OH +14 more
europepmc +1 more source
Broadly Protective Antibody‐Like Vaccines Against Highly Pathogenic Coronaviruses
ABSTRACT SARS‐CoV‐2 and MERS‐CoV are highly pathogenic and contagious coronaviruses. Despite intensive vaccination, SARS‐CoV‐2 continues to spread, and no FDA‐approved vaccines exist for MERS‐CoV; thus, more effective and safer vaccine options are needed. The receptor‐binding domain (RBD) of coronaviruses is a primary target of neutralizing antibodies (
Assala Helal +20 more
wiley +1 more source
Comparison of Immune Responses and Safety Profiles Following a Fourth Heterologous Dose (Second Booster) with mRNA-1273 in Individuals Previously Vaccinated with Two Doses of CoronaVac and a Booster Dose of Either AZD1222 or BNT162b2. [PDF]
Tangsathapornpong A +10 more
europepmc +1 more source
Booster mRNA Vaccination Prevents Breakthrough Severe COVID‐19 Infections
ABSTRACT This study aimed to assess the humoral immune response following administration of a BNT162b2 mRNA COVID‐19 booster dose and to evaluate its association with the development of SARS‐CoV‐2 infection after vaccination. Between July 2021 and February 2022, serum samples were collected from 313 individuals 28 days after receiving a COVID‐19 ...
Harika Öykü Dinç +12 more
wiley +1 more source

