Results 121 to 130 of about 700,500 (193)

Homologous and Heterologous Vaccination Regimens with mRNA and rVSV Platforms Induce Potent Immune Responses Against SFTSV Glycoprotein

Viruses
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a highly pathogenic bunyavirus with a high case-fatality ratio for which there is no approved vaccine. Studies have assessed different vaccine technologies.
Tomaz B. Manzoni, Jonna B. Westover, Kendall A. Lundgreen, Philip D. Hicks, Raegan J. Petch, Jordan T. Ort, Drew Weissman, Steven H. Y. Fan, Scott E. Hensley, Norbert Pardi, Brian B. Gowen, Paul Bates   +11 more
doaj   +1 more source

Heterologous Combination of VSV-GP and NYVAC Vectors Expressing HIV-1 Trimeric gp145 Env as Vaccination Strategy to Induce Balanced B and T Cell Immune Responses

Frontiers in Immunology, 2019
The generation of a vaccine against HIV-1 able to induce durable protective immunity continues a major challenge. The modest efficacy (31.2%) of the phase III RV144 clinical trial provided the first demonstration that a prophylactic HIV/AIDS vaccine is ...
Beatriz Perdiguero, Carmen Elena Gómez, Juan García-Arriaza, Cristina Sánchez-Corzo, Carlos Óscar S. Sorzano, Sarah Wilmschen, Dorothee von Laer, Benedikt Asbach, Christina Schmalzl, David Peterhoff, Song Ding, Ralf Wagner, Ralf Wagner, Janine Kimpel, Yves Levy, Yves Levy, Yves Levy, Giuseppe Pantaleo, Mariano Esteban   +18 more
doaj   +1 more source

Early Treg suppression by a Listeriolysin-O-expressing E. coli vaccine in heterologous prime-boost vaccination against cancer

, 2016
[[abstract]][Background] Earlier studies have shown that higher CD8+ T-cell response and better tumor protection can be achieved by heterologous prime-boost vaccination in mice. We previously demonstrated that a Listeriolysin-O (LLO)-expressing E.
Dai, MS;You, RI;Hsieh, YF;Lo, KY;Sytwu, HK;Vassaux, G;Chao, TY
core  

Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection

, 2018
The emergence of >300 serovars of Leptospira confounded the use of generalized bacterin, the whole cell lysate, as vaccines to control leptospirosis.
Charles Solomon Akino Mercy, Bianca Cotto, Durlav Prasad Bora, Kalimuthusamy Natarajaseenivasan, Veerapandian Raja, Sankaran Sobana   +5 more
core   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Enhanced cell immune responses to hepatitis c virus core by novel heterologous DNA prime/lambda nanoparticles boost in mice

, 2014
Hepatitis C virus (HCV) is a worldwide problem which does not have an effective vaccine and more than 170 million people worldwide are chronically infected by HCV. T cell responses are associated with spontaneous clearance of HCV infection.
Moradi, A., Adli, A.H., Tabarraei, A., Semnani, S., Hosseini, S.Y., Vakili, M.A., Gorji, A., Ghaemi, A., Saeedi, A., Soleimanjahi, H.   +9 more
core   +1 more source

A Confirmatory, Dual Center Nonhuman Primate Study on the Efficacy of Novel Oropharyngeal Spray Immunization With an Adenoviral Vector Vaccine Against RSV—Important Lessons Learned

Journal of Medical Primatology, Volume 55, Issue 6, December 2026.
ABSTRACT Background In a randomized, blinded, dual center study across two European primate research facilities, we evaluated the immunogenicity and protective efficacy of a DNA prime—oropharyngeal adenoviral boost vaccination strategy against respiratory syncytial virus (RSV).
Matthias Tenbusch, Gerrit Koopman, Petra Mooij, Berit Roshani, Pascal Irrgang, Dennis Lapuente, Ivanela Kondova, Willy M. Bogers, Edmond J. Remarque, Ramona Vestweber, Samuel Alberto Merida Ruiz, Nadine Krüger, Sebastian Meyer, Olaf Gefeller, Christiane Stahl‐Hennig, Klaus Überla   +15 more
wiley   +1 more source

Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev, Abubakar Siddiq Salihu, Lobar Khayrullaeva, Doniyor Khamdamov, Alex X. Gao, Kamila Mardieva, Wan Mohd Nuzul Hakimi Wan Salleh, Shakhnoz Azimova, Karl W. K. Tsim   +8 more
wiley   +1 more source

Nonreciprocity in CHIKV and MAYV Vaccine-Elicited Protection

Vaccines
Chikungunya virus (CHIKV) is a pathogenic arthritogenic alphavirus responsible for large-scale human epidemics for which a vaccine was recently approved for use.
Whitney C. Weber, Takeshi F. Andoh, Craig N. Kreklywich, Zachary J. Streblow, Michael Denton, Magdalene M. Streblow, John M. Powers, Gauthami Sulgey, Samuel Medica, Igor Dmitriev, David T. Curiel, Nicole N. Haese, Daniel N. Streblow   +12 more
doaj   +1 more source

Developing a personalized heterologous prime boost vaccination strategy for tumor therapy

, 2021
The limited success of therapeutic cancer vaccines to date is likely due to sub-optimal generation of anti-tumor CD8 T cells and insufficient tumor microenvironment (TME) modulation. In this study, a novel intravenous (IV) heterologous prime-boost vaccination strategy with a self-assembling neoantigen-peptide nanoparticle TLR-7/8 agonist (SNP) vaccine ...
openaire   +2 more sources