Results 111 to 120 of about 700,500 (193)

Heterologous prime-boost regimen adenovector 35-circumsporozoite protein vaccine/recombinant Bacillus Calmette-Guérin expressing the Plasmodium falciparum circumsporozoite induces enhanced long-term memory immunity in BALB/c mice

, 2012
BackgroundSustained antibody levels are a hallmark of immunity against many pathogens, and induction of long-term durable antibody titers is an essential feature of effective vaccines.
Troye-Blomberg, Marita,, Marita Troye-Blomberg, Fernandez, C., Reece, Stephen T., Rodriguez, Ariane, Kaufmann, Stefan H. E., Arama, C., Arama, Charles,, Fernández, Carmen,, Corradin, Giampietro, Charles Arama, Rodriguez, A., Yohannes Assefaw-Redda, Ariane Rodriguez, Carmen Fernández, Stefan H.E. Kaufmann, Reece, S., Corradin, G., Troye-Blomberg, M., Giampietro Corradin, Assefaw-Redda, Y., Stephen T. Reece, Kaufmann, S., Assefaw-Redda, Yohannes,, Reece, S.T., Kaufmann, S.H.   +25 more
core   +1 more source

S‑glutathionylation of MaWRKY44 orchestrates a MaZFP139‐MaWRKY44‐MaGSTU07 cascade to enhance banana cold tolerance

Journal of Integrative Plant Biology, EarlyView.
In banana, at low temperatures (7°C), the transcription factor MaZFP139 activates MaWRKY44 expression. MaWRKY44 binds to the W‐box sites in the promoter of the glutathione S‐transferase gene MaGSTU07 to enhance reactive oxygen species scavenging. S‐glutathionylation protects MaWRKY44 from oxidation‐induced degradation, reinforcing antioxidant defenses ...
Shuqin Lin, Wen Song, Shaoting Liao, Haike Tan, Jianji Qi, Danling Cai, Wei Wei, Wei Shan, Jianfei Kuang, Jianye Chen, Wangjin Lu   +10 more
wiley   +1 more source

Booster doses of an inactivated F genotype mumps vaccine enhance immunogenicity in mice

Vaccine: X
The mumps virus (MuV) causes a highly contagious human disease characterized by swelling of the parotid glands. Although the administration of an attenuated Jeryl Lynn (JL) MuV vaccine shows efficacy in reducing the incidence of MuV infection, sporadic ...
Seo Yeon Kim, Tae-Young Lee, Yun-Ho Hwang, Dokeun Kim, You-Jin Kim, Hyeran Won   +5 more
doaj   +1 more source

Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Journal of Translational Medicine, 2019
Background In non-human primates (NHPs) and humans, partial protection from HIV/SIV infection or suppression of replication is achievable by Env-binding antibodies and Gag-specific CD8+ T-cells targeting protective epitopes.
Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch, Peter Johannes Holst   +3 more
doaj   +1 more source

Patent landscape analysis of inventions based on plant genetic resources for food and agriculture and related digital sequence information

The Journal of World Intellectual Property, EarlyView.
Abstract This article provides an overview of the patent landscape in relation to PGRFA‐based inventions involving naturally occurring (“native”) traits and related Digital Sequence Information/Genetic Sequence Data (DSI/GSD). In particular, it focuses on the potential of patent claims to limit others' uses of PGRFA and related DSI/GSD on which the ...
Claudio Chiarolla, Michael Andreas Kock, Paul Oldham, Michael Halewood, Isabel López Noriega, Jasmine Kindness   +5 more
wiley   +1 more source

Spatiotemporal Transcriptomics Reveals That a ZF‐HD–GmCWINV4 Module Controls Carbon Partitioning and Seed Size in Soybean

Plant Biotechnology Journal, EarlyView.
ABSTRACT Seed size and oil content are key determinants of agronomic productivity in soybean (Glycine max). Although the ultrastructure and cellular composition of soybean seeds have been well characterised, the spatiotemporal expression patterns of genes governing sucrose transport and catabolism across distinct cell types remain poorly understood ...
Di Wu, Yiran Ding, Yang Tao, Xiaoyi Fu, Bing Han, Juan Song, Tianquan Yang, Tingshuang Yi, Wei Xu   +8 more
wiley   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

BvCaM7 Participates in Sugar Beet (Beta vulgaris L.) Resistance to CLS (Cercospora Leaf Spot) by Activating BvPAL via BvMYB108 and Is Accompanied by Calcium Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT CLS (Cercospora leaf spot) is a major constraint in sugar beet (Beta vulgaris L.) cultivation, yet the functions of CaM/CML family members in CLS resistance are unclear. This study identified the CaM/CML family in sugar beet and focused on BvCaM7, which was significantly upregulated under CLS. Calcium measurements revealed differential calcium
Meilin He, Hongyong Lou, Guangzhou Ding, Chunlei Zhao   +3 more
wiley   +1 more source

Creatine and cognitive function: Why has physiological plausibility not translated into convincing clinical evidence?

Experimental Physiology, EarlyView.
Abstract Creatine is among the most extensively studied and widely used nutritional supplements in sports and exercise science. Over the past two decades, however, interest has expanded well beyond skeletal muscle, driven by growing recognition of the central role played by the creatine–phosphocreatine system in cerebral bioenergetics.
Marco Machado
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source