Results 131 to 140 of about 700,500 (193)

Cellular immune responses induced in cattle by heterologous prime-boost vaccination using recombinant viruses and bacille Calmette-Guerin.

, 2004
The development of novel vaccine strategies to replace or supplement bacille Calmette-Guérin (BCG) is urgently required. Here we study, in cattle, the use of heterologous prime-boost strategies based on vaccination with BCG and the mycobacterial mycolyl ...
Nilu Goonetilleke, Sarah C. Gilbert, Gillian Dean, R. Glyn Hewinson, Kris Huygen, Adrian V. S. Hill, Shelley G. Rhodes, H. Martin Vordermeier   +7 more
core   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

Food Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing, Yaoyuan Hu, Yingying Ma, Peng Yao, Jingjing Jiang, Jiao Guo, Shuangmei Liu   +6 more
wiley   +1 more source

Mortality in severe serious adverse events following heterologous and homologous prime-boost vaccination strategies for SARS-CoV-2: A retrospective cohort study.

PLoS ONE
The COVID-19 pandemic underscored the urgent need for widespread vaccination to achieve herd immunity and mitigate severe outcomes. To address vaccine supply constraints, heterologous prime-boost strategies were adopted in Korea and other countries ...
Min Cheol Song, Jongmok Ha, Suyeon Park, Hyunwook Kang, Taeeun Kyung, Namoh Kim, Dong Kyu Kim, Kihoon Bae, Kwang Jun Lee, Euiho Lee, Jin Myoung Seok, Jinyoung Youn   +11 more
doaj   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, Volume 115, Issue 11, Page 2433-2440, November 2026.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Trained Immunity in Childhood Vaccination

Acta Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai, Lubnaa Hossenbaccus, Eva Kaufmann   +2 more
wiley   +1 more source

Exploring the Development of Vaccine Platforms, With a Particular Focus on the COVID‐19 Pandemic

Acta Paediatrica, Volume 115, Issue 11, Page 2421-2426, November 2026.
ABSTRACT Vaccines have been a cornerstone of human health for more than 200 years and one of the most important tools to reduce childhood deaths caused by pathogens. The concept of vaccines is basically to take something safe, make it immunogenic and induce an immune response in the host that will protect it against something dangerous. Live attenuated
Matti Sällberg
wiley   +1 more source

Converging GWAS and Genome Editing Decrypts MsCBF8‐MsGolS2 Regulatory Module for Drought Tolerance Without Yield Penalty in Medicago sativa

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5967-5984, November 2026.
ABSTRACT Drought constitutes a major abiotic stress limiting alfalfa productivity. To elucidate the genetic basis of drought tolerance, a genome‐wide association study (GWAS) was conducted in alfalfa, which identified a CBF/DREB1 family transcription factor designated MsCBF8.
Yangyang Zhang, Xueqian Jiang, Tian Zhang, Huajuan Leng, Jing Cui, Xu Jiang, Lili Zhang, Zhen Wang, Tiejun Zhang, Qingchuan Yang, Xue Wang, Junmei Kang   +11 more
wiley   +1 more source

Broadening SARS-CoV-2 Immunity by Combining ORFV and Protein-Based Vaccines

Vaccines
Background: Emerging immune-evasive viral variants threaten the efficacy of current vaccines, underscoring the need for strategies that elicit broad and durable protection.
Alena Reguzova, Melanie Müller, Madeleine Fandrich, Alex Dulovic, Ralf Amann   +4 more
doaj   +1 more source

Sorghum Metabolic Atlas: A fluorescent protein‐based subcellular localization resource for sorghum enzymes

The Plant Journal, Volume 128, Issue 3, November 2026.
SUMMARY Plant metabolism drives traits essential for productivity and resilience, yet understanding metabolic networks requires subcellular, cellular, and tissue‐level spatial context that remains limited, particularly in crop species. Experimentally derived subcellular localization data for enzymes are sparse, constraining analyses of metabolic ...
Purva Karia, William P. Dwyer, Ava Kloss‐Schmidt, Charles Hawkins, Bo Xue, Daniel Ginzburg, Maxine L. Gutierrez, Ritesh Mewalal, Ian Blaby, David W. Ehrhardt, Seung Y. Rhee   +10 more
wiley   +1 more source

Pooled Analysis of the Effect of Pre-Existing Ad5 Neutralizing Antibodies on the Immunogenicity of Adenovirus Type 5 Vector-Based COVID-19 Vaccine from Eight Clinical Trials

Vaccines
Background: Pre-existing adenovirus immunity restricts the utilization of adenovirus-vectored vaccines. The current study aims to conduct a pooled analysis of eight clinical trials to evaluate the influence of pre-existing Ad5 neutralizing antibodies on ...
Wenqing Liu, Yuqing Li, Xiaolong Li, Feiyu Wang, Runjie Qi, Tao Zhu, Jingxin Li   +6 more
doaj   +1 more source