Results 51 to 60 of about 700,500 (193)

Heterologous prime–boost vaccination [PDF]

Current Opinion in Immunology, 2009
An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens.
openaire   +2 more sources

Comparison of multiple vaccine vectors in a single heterologous prime-boost trial [PDF]

Vaccine, 2008
The prevention of infectious disease via prophylactic immunization is a mainstay of global public health efforts. Vaccine design would be facilitated by a better understanding of the type and durability of immune responses generated by different vaccine vectors.
Brice, Barefoot, Natalie J, Thornburg, Daniel H, Barouch, Jae-Sung, Yu, Christopher, Sample, Robert E, Johnston, Hua Xin, Liao, Thomas B, Kepler, Barton F, Haynes, Elizabeth, Ramsburg   +9 more
openaire   +2 more sources

Heterologous prime-boost Zika virus vaccination induces comprehensive humoral and cellular immunity in mouse models. [PDF]

Front Immunol
Zika virus (ZIKV) remained poorly studied until an outbreak in 2015 linked the virus to severe neurological disorders and congenital malformations. Currently, there are no antiviral drugs or vaccines available.
De Lorenzo G, Tandavanitj R, Preciado-Llanes L, Sanchez-Velazquez R, Prado Rocha R, Kim YC, Reyes-Sandoval A, Patel AH.   +7 more
europepmc   +2 more sources

Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors [PDF]

Vaccine, 2009
Pre-existing immunity to human adenovirus serotype 5 (AdHu5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAdHu5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. As a potential solution to this problem we developed adenovirus vaccine vectors of chimpanzee origin.
Sampa, Santra, Yue, Sun, Birgit, Korioth-Schmitz, Julie, Fitzgerald, Cherie, Charbonneau, Giannina, Santos, Michael S, Seaman, Sarah J, Ratcliffe, David C, Montefiori, Gary J, Nabel, Hildegund C J, Ertl, Norman L, Letvin   +11 more
openaire   +2 more sources

Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model [PDF]

, 2018
With the increasing prevalence of artemisinin-resistant malaria parasites, a highly efficacious and durable vaccine for malaria is urgently required.
Shahid M. Khan, Hill, A.V.S., Iyori, Mitsuhiro, Yusuf, Yenni, Yusuf, Y., Yoshii, Tatsuya, Salman, A.M., Yamamoto, Daisuke S, Mitsuhiro Iyori, Katarzyna A. Sala, Salman, Ahmed M, Ahmed M. Salman, Kunitaka Yoshida, Chris J. Janse, Tokoro, Masaharu, Tatsuya Yoshii, Iyori, M., Sumi Biswas, Yoshida, Shigeto, Janse, C.J., Blagborough, Andrew M, Biswas, S., Khan, Shahid M, Daisuke S. Yamamoto, Shigeto Yoshida, Andrew M. Blagborough, Blagborough, A.M., Sala, K.A., Hill, Adrian VS, Khan, S.M., Yoshii, T., Dulal, Pawan, Dulal, P., Masaharu Tokoro, Tokoro, M., Janse, Chris J, Yoshida, K., Yamamoto, D.S., Yoshida, Kunitaka, Biswas, Sumi, Sala, Katarzyna A, Yenni Yusuf, Pawan Dulal, Adrian V. S. Hill, Yoshida, S.   +44 more
core   +2 more sources

Accelerated Heterologous Adenovirus Prime-Boost SIV Vaccine in Neonatal Rhesus Monkeys [PDF]

Journal of Virology, 2012
ABSTRACT A pediatric human immunodeficiency virus type 1 (HIV-1) vaccine would be desirable to protect infants against HIV-1 transmission from breast-feeding. Such a vaccine would need to induce protective immunity at mucosal surfaces in neonates as soon as possible after birth.
Jinyan, Liu, Hualin, Li, M Justin, Iampietro, Dan H, Barouch   +3 more
openaire   +2 more sources

CD4 and CD8 T cell responses to the M. tuberculosis Ag85B-TB10.4 promoted by adjuvanted subunit, adenovector or heterologous prime boost vaccination. [PDF]

PLoS ONE, 2009
BackgroundAlthough CD4 T cells are crucial for defense against M.tb, it is still not clear whether the optimal response against M.tb in fact involves both CD4 and CD8 T cells.
Tara Elvang, Jan P Christensen, Rolf Billeskov, Truc Thi Kim Thanh Hoang, Peter Holst, Allan Randrup Thomsen, Peter Andersen, Jes Dietrich   +7 more
doaj   +1 more source

Heterologous Prime/Boost Immunization of Rhesus Monkeys by Using Diverse Poxvirus Vectors [PDF]

Journal of Virology, 2007
ABSTRACT As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors.
Sampa, Santra, Yue, Sun, Jenny G, Parvani, Valerie, Philippon, Michael S, Wyand, Kelledy, Manson, Alicia, Gomez-Yafal, Gail, Mazzara, Dennis, Panicali, Phillip D, Markham, David C, Montefiori, Norman L, Letvin   +11 more
openaire   +2 more sources

Heterologous prime-boost immunizations with chimpanzee adenoviral vectors elicit potent and protective immunity against SARS-CoV-2 infection

Cell Discovery, 2021
A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed to tackle the COVID-19 global pandemic. Here, we describe the development of chimpanzee adenovirus serotypes 6 and 68 (AdC6 and AdC68) vector-
Jiaojiao Liu, Kun Xu, Man Xing, Yue Zhuo, Jingao Guo, Meng Du, Qi Wang, Yaling An, Jinhe Li, Ping Gao, Yihan Wang, Furong He, Yingying Guo, Mingxi Li, Yuchao Zhang, Linqi Zhang, George F. Gao, Lianpan Dai, Dongming Zhou   +18 more
doaj   +1 more source

rCSP/Ad35CS Heterologous Prime-Boost Regimens.

, 2014
C57BL/6 mice were immunized with rCSP formulated in GLA-SE or Ad35CS according to the regimens shown.rCSP/Ad35CS Heterologous Prime-Boost Regimens.
Hongfan Jin (632861), Brian Roberts (413821), Ryan Haverstock (632863), Jeffrey R. Allen (632864), Fidel Zavala (227282), Gabriel M. Gutierrez (632868), John Sacci (632867), Moriya Tsuji (302022), Ryota Funakoshi (632859), Scott B. Winram (632866), Diane M. Retallack (632862), Amy R. Noe (632857), Steve Giardina (632860), Ramses Ayala (632865), Jordana G. A. Coelho-dos-Reis (585966), Diego Espinosa (632858), Xiangming Li (302018), Christopher B. Fox (231826), Thomas S. Vedvick (231840), Steven G. Reed (173670)   +19 more
core   +1 more source