Results 61 to 70 of about 700,500 (193)

Heterologous ChAdOx1 nCoV-19/BNT162b2 Prime-Boost Vaccination Induces Strong Humoral Responses among Health Care Workers

, 2021
Despite limited data on safety and immunogenicity, heterologous prime-boost vaccination is currently recommended for individuals with ChAdOx1 nCoV-19 prime immunization in certain age groups.
Florian Kälble, Christian Morath, Mirabel Buylaert, Julia Grenz, Paul Schnitzler, Maximilian Töllner, Christian Nusshag, Gerald Ponath, Caner Süsal, Katrin Klein, Martin Zeier, Claudius Speer, Louise Benning, Matthias Schaier, Asa Hidmark, Paula Reichel   +15 more
core   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapse

OncoImmunology, 2020
Therapeutic cancer vaccines aim to induce an effective immune response against cancer, and the effectiveness of these vaccines is influenced by the choice of immunogen, vaccine type, and immunization strategy.
Qianqian Guo, Lizheng Wang, Ping Xu, Fei Geng, Jie Guo, Ling Dong, Xin Bao, Yi Zhou, Mengfan Feng, Jiaxin Wu, Hui Wu, Bin Yu, Haihong Zhang, Xianghui Yu, Wei Kong   +14 more
doaj   +1 more source

Ebola-GP DNA Prime rAd5-GP Boost: Influence of Prime Frequency and Prime/Boost Time Interval on the Immune Response in Non-human Primates

Frontiers in Immunology, 2021
Heterologous prime-boost immunization regimens are a common strategy for many vaccines. DNA prime rAd5-GP boost immunization has been demonstrated to protect non-human primates against a lethal challenge of Ebola virus, a pathogen that causes fatal ...
Hadar Marcus, Emily Thompson, Yan Zhou, Michael Bailey, Mitzi M. Donaldson, Daphne A. Stanley, Clement Asiedu, Kathryn E. Foulds, Mario Roederer, Juan I. Moliva, Nancy J. Sullivan   +10 more
doaj   +1 more source

Vesicular stomatitis virus-based vaccines protect nonhuman primates against Bundibugyo ebolavirus. [PDF]

PLoS Neglected Tropical Diseases, 2013
Ebola virus (EBOV) causes severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Currently, there are no licensed vaccines or therapeutics for human use. Recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which
Chad E Mire, Joan B Geisbert, Andrea Marzi, Krystle N Agans, Heinz Feldmann, Thomas W Geisbert   +5 more
doaj   +1 more source

Immunogenicity of heterologous prime/boost inactivated and mRNA COVID-19 vaccine [PDF]

, 2021
Abstract Introduction In August 2021, Thailand imported the BNT162b2 mRNA COVID-19 vaccine. The prioritised group to receive the BNT162b2 vaccine were health professionals. The BNT162b2 vaccine scheduled for healthcare workers were two-dose regimen administered three weeks apart, the third dose ...
Wanlapakorn N, Yorsaeng R, Phowatthanasathian H, Suntronwong N, Kanokudom S, Sudhinaraset N, Poovorawan Y.   +6 more
europepmc   +2 more sources

Heterologous prime–boost reshapes antibody responses enhancing levels of site II–specific antibodies.

, 2019
(A) Heterologous prime–boost study groups. Three mouse cohorts were immunized with either 1x RSVF (“prime-only”), 3x RSVF (“homologous boost”), or 1x RSVF followed by two boosts with NRM (“heterologous boost”).
Bruno E. Correia (1328694), Stéphane Rosset (2533081), Marie-Anne Rameix-Welti (207166), Lucia Csepregi (6388115), Marie Galloux (4899214), Man Chen (207577), Sabine Riffault (162517), Barney S. Graham (194312), Fabian Sesterhenn (3075192), Patricia Corthésy (6388118), Simon Friedensohn (561229), Che Yang (1651603), Jean-François Éléouët (6388121), Sai T. Reddy (167874), Pablo Gainza (188024), Jaume Bonet (34523), Sabrina S. Vollers (2728831), Delphyne Descamps (142528)   +17 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost [PDF]

npj Vaccines, 2019
AbstractHighly pathogenic avian influenza (HPAI) A(H5Nx) viruses continue to pose a pandemic threat. US national vaccine stockpiles are a cornerstone of the influenza pandemic preparedness plans. However, continual genetic and antigenic divergence of A(H5Nx) viruses requires the development of effective vaccination strategies using stockpiled vaccines ...
Min Z. Levine, Crystal Holiday, Stacie Jefferson, F. Liaini Gross, Feng Liu, Sheng Li, Damien Friel, Philippe Boutet, Bruce L. Innis, Corey P. Mallett, Terrence M. Tumpey, James Stevens, Jacqueline M. Katz   +12 more
openaire   +2 more sources

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source