Results 71 to 80 of about 700,500 (193)

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Analyzing immune responses to varied mRNA and protein vaccine sequences

npj Vaccines, 2023
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have been developed against SARS-CoV-2. This has unintentionally created a unique scenario where heterologous
Hyeong-Jun Park, Yoo-Jin Bang, Sung Pil Kwon, Woori Kwak, Sang-In Park, Gahyun Roh, Seo-Hyeon Bae, Jae-Yong Kim, Hye Won Kwak, Yongkwan Kim, Soyeon Yoo, Daegeun Kim, Gyochang Keum, Eun-Kyoung Bang, So-Hee Hong, Jae-Hwan Nam   +15 more
doaj   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Progresses in DNA-Based Heterologous Prime-Boost Immunization Strategies

, 2014
Although recombinant DNA and recombinant viral vectors expressing HIV antigens have yielded positive outcomes in animal models, these vaccines have not been effectively translated to humans. Despite this, there is still a high level of optimism that poxviral-based vaccine strategies could offer the best hope for developing an effective vaccine against ...
Jackson, Ronald, Boyle, David B, Ranasinghe, Charani   +2 more
openaire   +3 more sources

Simplified steps to heterologous prime-boost HIV vaccine development? [PDF]

Journal of Clinical Investigation, 2019
The RV 144 HIV vaccine efficacy study showed a reduction in HIV-1 infection risk in Thai volunteers who received two priming vaccinations of vCP1521 ALVAC (attenuated recombinant canarypox virus expressing HIV group-specific antigen, polymerase, and envelope genes) followed by two additional ALVAC vaccinations and coadministration of purified bivalent ...
openaire   +2 more sources

Heterologous DNA Prime- Subunit Protein Boost with Chikungunya Virus E2 Induces Neutralizing Antibodies and Cellular-Mediated Immunity

, 2023
Chikungunya virus (CHIKV) has become a significant public health concern due to the increasing number of outbreaks worldwide and the associated comorbidities.
Edgar Ruz Fernandes, Carla Torres Braconi, Lucas Rodrigues de Mello, Gúbio Soares Campos, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Fernanda Caroline Coirada, Viviane Schuch   +7 more
core   +1 more source

Heterologous boost with mRNA vaccines against SARS-CoV-2 Delta/Omicron variants following an inactivated whole-virus vaccine [PDF]

, 2023
The coronavirus SARS-CoV-2 has mutated quickly and caused significant global damage. This study characterizes two mRNA vaccines ZSVG-02 (Delta) and ZSVG-02-O (Omicron BA.1), and associating heterologous prime-boost strategy following the prime of a most ...
Lin, Kang, Yang, Guohuan, Hua, Xianwu, Zhang, Yuntao, Xu, Jiang, Li, Xinguo, Liu, Fei, Jia, Rui, Li, Yuwei, Hu, Chunxia, Yang, Xiaoming, Lu, Jia, Liu, Lianxiao, Liu, Xiaohu, Zhang, Qiu, Liu, Xiaoke, Ding, Jun, Fan, Huifen, Lu, Changrui, Wang, Hui, Zhao, Ronghua, Pan, Xinping, Hou, Fujun, Li, Jing, Cheng, Xinhua, Cai, Rujie, Wang, Xuewei, Huang, Hongwei, Cheng, Hang, Yu, Zhibin, Jia, William, Wang, Zejun, Xu, Fangjingwei, Zejun Wang, Jiang Xu, Chunxia Hu, Jing Li, Rui Jia, Jia Lu, Kang Lin, Xinguo Li, Xiaoming Yang, Xianwu Hua, Ronghua Zhao, Lianxiao Liu, Rujie Cai, Zhibin Yu, Hui Wang, Xiaohu Liu, Xinping Pan, Qiu Zhang, Changrui Lu, Jun Ding, Xiaoke Liu, William Jia, Hang Cheng, Fangjingwei Xu, Yuntao Zhang, Hongwei Huang, Fei Liu, Xinhua Cheng, Yuwei Li, Guohuan Yang, Xuewei Wang, Huifen Fan, Fujun Hou   +65 more
core   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source