Results 231 to 240 of about 32,734 (287)

In Silico Design and Computational Characterization of Novel Chimeric Multiepitope Antigens for Mpox Serosurveillance: An Immunoinformatics Approach

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims The Monkeypox (Mpox) virus is a zoonotic Orthopoxvirus with a global outbreak that began in 2022, with more than 132,000 confirmed cases and 1500 deaths across over 128 countries. The pandemic preparedness pipeline emphasizes the importance of diagnostic surveillance of pathogens in at‐risk populations to monitor ...
Roland Ngwese Akwelle, Robert Adamu Shey, Mary Teke Efeti, Lekeayi Nelson Acha, Gordon Takop Nchanji, Yanick Aqua Stong Tangan, Joan Amban Chick, Ntang Emmaculate Yaah, Lahngong Methodius Shinyuy, Cabirou Mounchili Shintouo, Bernis Neneyoh Yengo, Abey Blessings Ayuk, Junior Ekunidi Engarimbi, Ketura Yaje Gwei, Brinate Teke Tebo, Derrick Neba Nebangwa, Beltine Muyer Tamnjong, Luc Vanhamme, Jacob Souopgui, Vincent P. K. Titanji, Stephen Mbigha Ghogomu   +20 more
wiley   +1 more source

Diversity and distribution of bacterial phytases

iMetaOmics, Volume 3, Issue 2, June 2026.
Phytases: The stepwise dephosphorylation of phytate is catalyzed by phytases, a group of enzymes found mainly among bacteria and plants. Bacterial potential: We identified an unexpectedly widespread and previously underappreciated bacterial potential for phytate dephosphorylation, suggesting that microbial phytases play crucial roles in the ...
Michael Weber, Lena‐Sophie Paul, Thilo M. Fuchs   +2 more
wiley   +1 more source

Bacterial Extracellular Vesicles (BEVs) Derived from Chryseobacterium Inhibit Dengue Virus Infection by Disrupting Its Structural Integrity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
This study elucidates a novel antiviral mechanism of bacterial BEVs, which are shown to inactivate viruses by triggering membrane fusion, subsequent lysis and causing structural collapse. This direct virucidal action presents a promising broad‐spectrum strategy against diverse enveloped viruses.
Yaqi Gao, Lijian Zhang, Tianci Zhang, Qiufeng Yao, Ruifang Gao, Yue Wang, Yunpeng Zhao, Tingting Zhou, Jikuai Chen, Xing Zhang, Hao Ren, Yongzhe Zhu, Ping Zhao, Zhongtian Qi, Li Luo, Zhaoling Qin   +15 more
wiley   +1 more source

Broadly Protective Antibody‐Like Vaccines Against Highly Pathogenic Coronaviruses

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT SARS‐CoV‐2 and MERS‐CoV are highly pathogenic and contagious coronaviruses. Despite intensive vaccination, SARS‐CoV‐2 continues to spread, and no FDA‐approved vaccines exist for MERS‐CoV; thus, more effective and safer vaccine options are needed. The receptor‐binding domain (RBD) of coronaviruses is a primary target of neutralizing antibodies (
Assala Helal, Najwa D. Aljehani, Aishah Ghazwani, Reem M. Alsulaiman, Faris Alyami, Wesam H. Abdulaal, Asem Alsharef, Maimonah Alghanmi, Ayat Zawawi, Ala A. Azhari, Afnan Almehmadi, Jood Balula, Tarfa Altorki, Rowa Y. Alhabbab, Muhammad Yasir Khan, Khalid Alluhaybi, Aisha Alnami, Thikryat Neamatallah, Turki S. Abujamel, Mohamed A. Alfaleh, Anwar M. Hashem   +20 more
wiley   +1 more source

Effect of heterologous vaccination regimen with Ad5-nCoV CanSinoBio and BNT162b2 Pfizer in SARS-CoV-2 IgG antibodies titers

, 2021
Romero-Ibarguengoitia ME, González Cantú A, Hernández-Ruíz YG, Amerndariz-Vázquez AG, Rivera-Salinas D, Montelongo-Cruz LP, del Río-Parra GF, Barco-Flores IA, González-Facio R, Sanz-Sánchez MÁ.   +9 more
europepmc   +1 more source

Booster mRNA Vaccination Prevents Breakthrough Severe COVID‐19 Infections

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT This study aimed to assess the humoral immune response following administration of a BNT162b2 mRNA COVID‐19 booster dose and to evaluate its association with the development of SARS‐CoV‐2 infection after vaccination. Between July 2021 and February 2022, serum samples were collected from 313 individuals 28 days after receiving a COVID‐19 ...
Harika Öykü Dinç, Hayriye Kirkoyun. Uysal, Günay Can, Beyhan Budak, Ferhat Osman Daşdemir, Elif Keskin, Okan Aydoğan, İlker İnanç Balkan, Rıdvan Karaali, Suat Saribaş, Sevgi Ergin, Neşe Saltoğlu, Bekir Kocazeybek   +12 more
wiley   +1 more source

CISP, an Intrinsically Disordered Cold‐Inducible Barley Protein, Functions as a Small RNA Chaperone

Plant Direct, Volume 10, Issue 6, June 2026.
ABSTRACT Low temperatures are a major environmental stress that limits plant growth and development. Understanding the molecular mechanism of cold tolerance is therefore essential for improving crop performance through molecular breeding. In this study, we focused on CISP, a small, previously uncharacterized protein, specifically induced in barley ...
Yutaro Okumura, Md. Maksudul Haque, Shin‐ichiro Kidou   +2 more
wiley   +1 more source

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Early‐stage drug discovery relies on the availability of stable protein for reliable biophysical characterization of ligand binding. However, many Plasmodium falciparum proteins are challenging to produce in heterologous systems, which limits their experimental utility.
Marius Amann, Tim Sträßer, Oliver Einsle, Stefan Günther   +3 more
wiley   +1 more source

Nanobodies: A Promising Toolkit for Diagnostic Applications

SmartMat, Volume 7, Issue 3, June 2026.
This review focuses on camelid‐derived nanobodies (VHHs) and explains how their small size and high stability support robust diagnostic design. Applications across ELISA, lateral flow assays, and PET/SPECT imaging are summarized, along with clinical progress such as caplacizumab.
Wei Wu, Abid Ali, Li Sun, Jiahao Hu, Lina Hameed, Saba Shafi, Ali Raza, Khuzin Dinislam, Wenjing Xing, Long Rong, Jie Lin, Jian Ma   +11 more
wiley   +1 more source

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores

Environmental Microbiology, Volume 28, Issue 6, June 2026.
In reservoir‐associated RT033 strains, we observe a natural rewiring of spore germination that lowers the activation threshold and broadens bile‐salt specificity, enabling germination at low germinant levels and in response to typically inhibitory bile‐salts common in animal hosts.
Isabel Roseiro, Alexandra Nunes, Diogo Martins, Frederico Alves, Søren Persson, Adriano O. Henriques, Mónica Oleastro, Mónica Serrano   +7 more
wiley   +1 more source