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Here, we systematically assessed the safety and immunogenicity of the heterologous ChAd/BNT vaccination regimens.We evaluated the immunogenicity by the geometric mean titers ratio (GMTR) of the neutralizing antibody and anti-spike IgG. The safety of heterologous ChAd/BNT vaccination was evaluated using the pooled risk ratios (RRs) calculated by the ...
Hu, Yuxuan +9 more
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Vaccine, 2016
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important ...
Mitra Saadatian-Elahi +8 more
openaire +3 more sources
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as "off-target effects" suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important ...
Mitra Saadatian-Elahi +8 more
openaire +3 more sources
Cowpea mosaic virus as a vaccine carrier of heterologous antigens
Molecular Biotechnology, 2001The plant virus, cowpea mosaic virus (CPMV), has been developed as an expression and presentation system to display antigenic epitopes derived from a number of vaccine targets including infectious disease agents and tumors. These chimeric virus particles (CVPs) could represent a cost-effective and safe alternative to live replicating virus and ...
F R, Brennan, T D, Jones, W D, Hamilton
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Heterologous protection elicited by a live, attenuated, Leptospira vaccine
Veterinary Microbiology, 2018A previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of infection for cross-protective immunity. The vaccine elicited strong, significant cross-protection against lethal infection by strains representing four serologically distinct leptospiral serovars (Grippotyphosa, Australis ...
Gerald L. Murray +4 more
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Trained immunity: consequences for the heterologous effects of BCG vaccination
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2015A growing body of evidence from epidemiologic and immunologic studies have shown that in addition to target disease-specific effects, vaccines have heterologous effects towards unrelated pathogens. Like some other vaccines, bacille Calmette-Guerin (BCG) has shown in observational studies and randomized clinical trials to increase survival beyond the ...
Kleinnijenhuis, J. +2 more
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A prime–boost vaccination of mice with heterologous H5N1 strains
Vaccine, 2009We evaluated the priming effect of an H5N1 pandemic vaccine in a mouse model to investigate strategies for influenza pandemic vaccination. For priming, an alum-adjuvanted inactivated whole H5N1 vaccine (NIBRG-14, clade 1) was used. As booster vaccines, several formulations of Indo05/05/2005(H5N1)PR8-IBCDC-RG2 vaccines (clades 2-1)were evaluated ...
Daisuke, Ikeno +7 more
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Heterologe Vaccination gegen Superinfekte mit Tuberkelbakterien
1961Fur Schutzimpfungen gegen bakterielle Infektionen werden homologe Vaccinen verwendet; dementsprechend gegen den tuberkulosen Infekt solche aus schwach virulenten Tuberkelbakterien. Der Vaccination mit heterologen (nicht-mycobakteriellen) Vaccinen hat man nur geringes Interesse geschenkt. Das ist berechtigt und verstandlich, soweit es sich um die Praxis
Enno Freerksen +2 more
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Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
2004Most of the vaccine strategies under development use multiple immunizations with the same agent such as a viral vector encoding a tumor antigen. More recently, the concept of heterologous prime-boost immunization has been tested in animal models. This strategy involves the sequential administration of different delivery vectors encoding the same ...
Michael J. Palmowski, Caroline Smith
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To mix or not to mix? A rapid systematic review of heterologous prime–boost covid-19 vaccination
Expert Review of Vaccines, 2021Daniel Tsung-Ning Huang +2 more
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