Results 221 to 230 of about 32,734 (287)

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Engineering a Virus‐Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis

Advanced Science, Volume 13, Issue 32, 9 June 2026.
In this study, a Faustovirus‐derived polymerase (FvPolX) is engineered based on structural and sequence analysis of PolX enzymes. The optimal mutants demonstrate substantially enhanced catalytic activity toward dNTPs and 3′‐ONH2‐dNTPs compared to the wild‐type enzyme.
Chengjie Zhang, Lei Du, Shengying Li
wiley   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli

Biotechnology Journal, Volume 21, Issue 6, June 2026.
Graphical Abstract and Lay Summary Producing recombinant proteins in Escherichia coli is often limited by the bacterium's tendency to consume glucose too rapidly. This excessive glucose uptake causes overflow metabolism, leading to the accumulation of acetate, a byproduct that can reduce cellular performance and protein production.
Juan Carlos Fragoso‐Jiménez, Juan Carlos Sigala, Frank Delvigne, Alfredo Martínez, Alvaro R. Lara, Guillermo Gosset   +5 more
wiley   +1 more source

All You Can Eat Yeast: Substituting Hexose Transporters With AtSWEET7 Alleviates Glucose Repression, Enabling Simultaneous Utilization of Sugars in Renewable Feedstocks

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1518-1530, June 2026.
ABSTRACT Yeast sugar transporters have highly evolved for preferential glucose transport, a significant roadblock for utilizing non‐glucose sugars in renewable feedstocks such as lignocellulosic biomass. To enable simultaneous transport of multiple sugars, native hexose transporters were replaced by SWEET7p from Arabidopsis thaliana in engineered ...
Nurzhan Kuanyshev, Degaulle Dai, Jungyeon Kim, Nam Kyu Kang, Ming‐Hsun Cheng, Vijay Singh, Yong‐Su Jin   +6 more
wiley   +1 more source

Comparative effectiveness and safety of homologous two-dose ChAdOx1 versus heterologous vaccination with ChAdOx1 and BNT162b2: a cohort analysis

, 2021
Prieto-Alhambra D, Hermosilla E, Coma E, Xie J, Feng S, Cabezas C, Méndez-Boo L, Fina F, Ballo E, Martínez M, Medina-Peralta M, Argimon JM.   +11 more
europepmc   +1 more source

Genetically Programmed Control of Overflow Metabolism

Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1624-1633, June 2026.
ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen, Andriy Glushchuk, Thilde P. Hjorth, Alvaro R. Lara   +3 more
wiley   +1 more source

Salt‐Driven Silk Fibroin Assembly for Solvent‐Free Multienzyme Co‐Immobilization

ChemCatChem, Volume 18, Issue 12, 26 June 2026.
Salt‐induced silk fibroin assembly enables solvent‐free co‐immobilization of redox enzyme cascades in fully aqueous media without covalent modification. The protein matrix provides high operational stability and modulates cofactor accessibility, enhancing functional coupling within the confined microenvironment.
Juan Cruz Almada, Miguel Marco‐Martín, Uriel A. Ruiz‐Castillo, Susana Velasco‐Lozano   +3 more
wiley   +1 more source

Induction of Humoral and Cellular Immunity After SARS‐CoV‐2 JN.1 Vaccination in Individuals With and Without Prior Infection

European Journal of Immunology, Volume 56, Issue 6, June 2026.
JN.1 vaccination induced strong, cross‐reactive CD4 and CD8 T‐cell responses and markedly boosted neutralizing antibodies, especially against omicron variants. Influenza vaccine coadministration did not impair immunogenicity. Prior SARS‐CoV‐2 infection was associated with higher baseline and postvaccine neutralizing activity, while cellular responses ...
Caroline Diener, Rebecca Urschel, Saskia Bronder, Candida Guckelmus, Johannes Eckel, Franziska Hielscher, Denisa Bojkova, Sandra Ciesek, Marek Widera, Tina Schmidt, Martina Sester   +10 more
wiley   +1 more source

Engineering a Hybrid Heme Pathway for Hemoprotein‐Based Dye‐Decolorizing Peroxidase in Escherichia coli

Food Bioengineering, Volume 5, Issue 2, Page 209-219, June 2026.
In this study, the heme content and enzymatic activity of the RhDypB mutant strain RhDypB‐R80 were enhanced through optimized heme uptake and pathway integration. This engineered host presents a promising platform for hemoprotein engineering and holds potential for applications in controlling mycotoxin contamination in food products.
Yue Sun, Jin‐Ping Chen, Nan‐Kai Wang, Chang Su, Heng Li, Jin‐Song Gong, Zheng‐Hong Xu, Jin‐Song Shi   +7 more
wiley   +1 more source