Results 11 to 20 of about 219 (120)

Natural products for anti-fibrotic therapy in idiopathic pulmonary fibrosis: marine and terrestrial insights. [PDF]

Front Pharmacol
Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrotic interstitial lung disease (ILD) of unknown etiology, characterized by increasing incidence and intricate pathogenesis.
Ma M, Chu Z, Quan H, Li H, Zhou Y, Han Y, Li K, Pan W, Wang DY, Yan Y, Shu Z, Qiao Y.   +11 more
europepmc   +3 more sources

Comparison of Chemical Compositions in Pseudostellariae Radix from Different Cultivated Fields and Germplasms by NMR-Based Metabolomics

Molecules, 2016
Pseudostellariae Radix (PR) is an important traditional Chinese medicine (TCM), which is consumed commonly for its positive health effects. However, the chemical differences of PR from different cultivated fields and germplasms are still unknown.
Yujiao Hua, Ya Hou, Shengnan Wang, Yang Ma, Zixiu Liu, Lisi Zou, Xunhong Liu, Yiyuan Luo, Juanxiu Liu   +8 more
doaj   +3 more sources

Host heterogeneity in humoral bactericidal activity can be complement independent. [PDF]

Front Immunol
BackgroundHumoral bactericidal activity was first recognized nearly a century ago. However, the extent of inter-individual heterogeneity and the mechanisms underlying such heterogeneity beyond antibody or complement systems have not been well studied ...
Abe R, Ram-Mohan N, Zudock EJ, Lewis S, Carroll KC, Yang S.   +5 more
europepmc   +3 more sources

Identification and expression analysis of R2R3-MYB transcription factor in Pseudostellaria heterophylla

Guangxi Zhiwu
R2R3-MYB transcription factor plays an important role in plant growth and development, stress response, and secondary metabolism. In order to explore the temporal and spatial expression pattern of R2R3-MYB transcription factors in Pseudostellaria ...
HUANG Yishu, HE Hua, ZHOU Tao, PAN Qi, LIU Hongxia, XU Jiao, OU Xiaohong, JIANG Weike*
doaj   +2 more sources

Muribaculum intestinale-derived 3-hydroxybutyric acid from Heterophyllin B attenuated pulmonary fibrosis through IDO1-mediated ferroptosis

Pharmacological Research
Pulmonary fibrosis (PF) is a fatal disease with increasing incidence, poor prognosis, and unclear pathogenesis. Our previous research demonstrated the beneficial effects of the natural cyclopeptide Heterophyllin B (HB) in PF.
Ce Chen, Jialin Wang, Mengqin Cheng, Haifeng Xie, Wei Li, Chaofeng Zhang   +5 more
doaj   +3 more sources

Harnessing nature's pharmacy: investigating natural compounds as novel therapeutics for ulcerative colitis. [PDF]

Front Pharmacol
BackgroundsUlcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research and development of new drugs for the treatment of UC are urgent, and natural compounds are an ...
Huang Y, Wu Q, Li S, Lin X, Yang S, Zhu R, Fu C, Zhang Z.   +7 more
europepmc   +3 more sources

Paclobutrazol suppresses the synthesis of key secondary metabolites by antagonizing gibberellin signaling in Pseudostellaria heterophylla

Biomedical Chromatography, 2023
Background：Pseudostellaria heterophyllais one of the most well-known traditional Chinese medicines, and its secondary metabolites play an important medicinal role.
Changgui Yang, Chen Zhang, Chenghong Xiao, Jiao Xu, Jinqiang Zhang, Liangyuan Li, Qingsong Yuan, Tao Zhou, Taosheng Wu, Zhen Ouyang   +9 more
core   +4 more sources

Heterophyllin B inhibits the adhesion and invasion of ECA-109 human esophageal carcinoma cells by targeting PI3K/AKT/β-catenin signaling. [PDF]

Mol Med Rep, 2016
The present study aimed to measure the effect of heterophyllin B (HB) on the adhesion and invasion of ECA-109 human esophageal carcinoma cells, and examine the possible mechanism involved. A Cell Counting kit 8 assay was performed to determine the cell viability.
Tantai JC, Zhang Y, Zhao H.
europepmc   +4 more sources

Structure-Based Virtual Screening and Molecular Docking on the Indonesian Herbal Compound as a Promising Insulin Receptor (INSR) Inhibitor to Suppress Tumor Growth [PDF]

, 2023
A healthy cell maintains a homeostasis condition of glucose level, whereas cancer cells do not. Increased glucose uptake is a hallmark of cancer cells that helps them survive, proliferate, and spread.
Candraningrum, Veronica Hesti, Dwira, Surya, Erlina, Linda, Fadillah, Fadillah, Fatriansyah, Jaka Fajar, Paramita, Rafika Indah   +5 more
core   +2 more sources

Heterophyllin B enhances transcription factor EB-mediated autophagy and alleviates pyroptosis and oxidative stress after spinal cord injury. [PDF]

Int J Biol Sci
Traumatic spinal cord injury (SCI) has devastating physical, psychosocial, and vocational implications for patients and caregivers. Heterophyllin B (HB) is a brain-permeable cyclopeptide from Pseudostellaria heterophylla that promotes axonal regeneration and neuroinflammation.
Zhang H, Wang W, Hu X, Wang Z, Lou J, Cui P, Zhao X, Wang Y, Chen X, Lu S.   +9 more
europepmc   +3 more sources