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[Ursolic acid in <i>Huajie Xiaoliu</i> Formula inhibits colorectal cancer cell growth by inducing cuproptosis]. [PDF]
Nan Fang Yi Ke Da Xue Xue BaoJin C +7 more
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Investigating Potential Anti-Bacterial Natural Products Based on Ayurvedic Formulae Using Supervised Network Analysis and Machine Learning Approaches. [PDF]
Pharmaceuticals (Basel)Gao P +4 more
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Therapeutic Potential of Qilianxiaopi Formula: Targeting ADAM17-Mediated Chronic Inflammation in Atrophic Gastritis. [PDF]
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Heterophyllin B ameliorates gastric cancer tumor growth through activating ER stress
Tissue and Cell, 2023Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Heterophyllin B (HB) has been proved to be a potential drug in cancer treatment.In the current study, GC cells were treated with 0, 10, 25, or 50 μM of HB. Cell viability was determined by utilizing MTT assay.
Zheng Hao
exaly +3 more sources
European Journal of Pharmacology, 2022
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with unknown etiology. In the present study, we evaluated the anti-fibrotic effects of heterophyllin B, a natural product from Radix Pseudostellariae having anti-inflammatory and tyrosinase inhibitory activities. In bleomycin (BLM)-induced PF mouse model, heterophyllin B treatments (5 or 20
Yanliang Wu +2 more
exaly +3 more sources
Pulmonary fibrosis (PF) is a chronic interstitial lung disease with unknown etiology. In the present study, we evaluated the anti-fibrotic effects of heterophyllin B, a natural product from Radix Pseudostellariae having anti-inflammatory and tyrosinase inhibitory activities. In bleomycin (BLM)-induced PF mouse model, heterophyllin B treatments (5 or 20
Yanliang Wu +2 more
exaly +3 more sources
Heterophyllin B inhibits the malignant phenotypes of gastric cancer cells via CXCR4
Human Cell, 2022Heterophyllin B (HB) is a cyclic lipopeptide that has been shown to have anticancer effects. This study intended to further explore the effects and modulatory mechanism of HB in gastric cancer (GC) cells. The binding relationship between HB and CXCR4 was investigated by network pharmacological analysis, molecular docking, and cellular thermal shift ...
Yunhai Wei, Yuhai Gao
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Food Research International, 2022
Pseudostellaria heterophylla, has historically been used as medicine food homology plant for thousand years in China. Our previous studies had indicated that daily intake of Pseudostellaria heterophylla extract enhanced cognitive memory. Herein, heterophyllin B (HET-B), a brain permeable cyclopeptide from Pseudostellaria heterophylla was determined ...
Zhiyou Yang
exaly +3 more sources
Pseudostellaria heterophylla, has historically been used as medicine food homology plant for thousand years in China. Our previous studies had indicated that daily intake of Pseudostellaria heterophylla extract enhanced cognitive memory. Herein, heterophyllin B (HET-B), a brain permeable cyclopeptide from Pseudostellaria heterophylla was determined ...
Zhiyou Yang
exaly +3 more sources
Phytomedicine
Pulmonary fibrosis (PF) is a chronic, lethal lung disease marked by permanent alterations to the lung tissue architecture. Although nintedanib (NDN) has been approved for clinical use, its therapeutic potential is substantially hampered by severe gastrointestinal side effects, notably diarrhea, which compromise patient adherence and quality of life ...
Ce Chen, Chaofeng Zhang
exaly +3 more sources
Pulmonary fibrosis (PF) is a chronic, lethal lung disease marked by permanent alterations to the lung tissue architecture. Although nintedanib (NDN) has been approved for clinical use, its therapeutic potential is substantially hampered by severe gastrointestinal side effects, notably diarrhea, which compromise patient adherence and quality of life ...
Ce Chen, Chaofeng Zhang
exaly +3 more sources
Molecular Nutrition and Food Research, 2022
ScopeAdvances in pathology broaden the perception of the intimate interaction between gut microbiota dysbiosis and the pathogenesis of ulcerative colitis (UC), but the potential modulating roles remain to be elucidated.Methods and resultsDSS‐induced colitis is used to investigate the effect of Heterophyllin B (HB), a typical active cyclopeptide ...
Ce Chen, Han Liang, Guoqing Ren
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ScopeAdvances in pathology broaden the perception of the intimate interaction between gut microbiota dysbiosis and the pathogenesis of ulcerative colitis (UC), but the potential modulating roles remain to be elucidated.Methods and resultsDSS‐induced colitis is used to investigate the effect of Heterophyllin B (HB), a typical active cyclopeptide ...
Ce Chen, Han Liang, Guoqing Ren
exaly +3 more sources
Plant Physiology and Biochemistry
As a popular medicinal plant, Pseudostellaria heterophylla has been attached to great importance in herbal medicine. Heterophyllin B (HB), isolated from P. heterophylla, is a strongly pharmacologically active cyclic peptide. However, the key enzymes that catalyze the HB biosynthesis remain unidentified.
Lanping Guo, Changgui Yang
exaly +3 more sources
As a popular medicinal plant, Pseudostellaria heterophylla has been attached to great importance in herbal medicine. Heterophyllin B (HB), isolated from P. heterophylla, is a strongly pharmacologically active cyclic peptide. However, the key enzymes that catalyze the HB biosynthesis remain unidentified.
Lanping Guo, Changgui Yang
exaly +3 more sources