Results 221 to 230 of about 61,296 (269)
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Heterotrimeric G proteins in heart disease
Canadian Journal of Physiology and Pharmacology, 2000Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh. In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, heart rate, and myocyte growth. This
O, Zolk +3 more
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Heterotrimeric G protein activation by G-protein-coupled receptors
Nature Reviews Molecular Cell Biology, 2008Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit.
William M, Oldham, Heidi E, Hamm
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Presynaptic Signaling by Heterotrimeric G-Proteins
2008G-proteins (guanine nucleotide-binding proteins) are membrane-attached proteins composed of three subunits, alpha, beta, and gamma. They transduce signals from G-protein coupled receptors (GPCRs) to target effector proteins. The agonistactivated receptor induces a conformational change in the G-protein trimer so that the alpha-subunit binds GTP in ...
David A, Brown, Talvinder S, Sihra
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Heterotrimeric G Proteins and Disease
2006Heterotrimeric G proteins attached to the cell membrane convey signals from G protein-coupled receptors in response to stimulation by a number of hormones, neurotransmitters, chemokines, and pharmacological agents to intracellular signaling cascades.
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2016
A major system used by eukaryotic organisms to sense and respond to environmental stimuli involves heterotrimeric G-proteins and their cognate membrane-bound receptors, known as G protein-coupled receptors (GPCRs). This chapter introduces the components of heterotrimeric G-protein-mediated signaling and highlights the effector pathways downstream of ...
Rekha Deka +3 more
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A major system used by eukaryotic organisms to sense and respond to environmental stimuli involves heterotrimeric G-proteins and their cognate membrane-bound receptors, known as G protein-coupled receptors (GPCRs). This chapter introduces the components of heterotrimeric G-protein-mediated signaling and highlights the effector pathways downstream of ...
Rekha Deka +3 more
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Heterotrimeric G-proteins in plant development
Frontiers in Bioscience, 2008Signaling through heterotrimeric G-proteins (G-proteins) is a conserved mechanism found in all eukaryotes. In plants, the repertoire of G-protein signaling complex is much simpler than in metazoans. Specifically, the genome of the model plant, Arabidopsis, encodes only one canonical Galpha, one Gbeta, and two Ggamma subunits.
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Biology of heterotrimeric G-protein signaling
Critical Care Medicine, 2000The G proteins are components of a complex membrane signaling system designed to modulate extracellular signals as they are transmitted into the cell. The principal components are the receptor, the G proteins including the alpha, beta, gamma subunits and the effector.
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Small molecules targeting heterotrimeric G proteins
European Journal of Pharmacology, 2018G protein-coupled receptors (GPCRs) represent the largest family of cell surface receptors regulating many human and animal physiological functions. Their implication in human pathophysiology is obvious with almost 30-40% medical drugs commercialized today directly targeting GPCRs as molecular entities.
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Heterotrimeric G proteins in crop improvement
Molecular Plant, 2023Yating Dong, Ting-Ying Wu, Daisuke Urano
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The contemporary management of cancers of the sinonasal tract in adults
Ca-A Cancer Journal for Clinicians, 2023Rajat Thawani
exaly