Results 101 to 110 of about 299,280 (207)

Patient with homozygous familial hypercholesterolemia: difficult to treat. Case report

, 2020
Homozygous familial hypercholesterolemia is a severe genetic disorder characterized by extremely high levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C), as well as by rapid atherosclerosis progression in various vascular ...
Andrey V. Susekov, Irina V. Leontieva, Balakhonova T.V., Vladislav M. Soloviev, Irina M. Miklashevich, Yuliia S. Isaeva, Vladislav Soloviev, Andrey Susekov, Tatyana Balakhonova, null null, Irina Leontieva, Yuliia Isaeva, Irina Miklashevich   +12 more
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Familial hypercholesterolemia Ailesel hiperkolesterolemi

, 2006
Familial hypercholesterolemia is a hereditary disease characterized with the increase of LDL- cholesterol level in plasma as a result of mutational defect of LDL receptor gene. The disease presents in two forms as homozygous and heterozygous.
Güzelmansur, Ismail, Sangün, Özlem, Akçali, Cenk, Incecik, Faruk   +3 more
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Mipomersen and other therapies for the treatment of severe familial hypercholesterolemia

Vascular Health and Risk Management, 2012
Damon A Bell,1–3 Amanda J Hooper,1,2,4 Gerald F Watts,2,3 John R Burnett1–41Department of Core Clinical Pathology and Biochemistry, PathWest Laboratory Medicine, 2School of Medicine and Pharmacology, 3Lipid Disorders Clinic ...
Bell DA, Hooper AJ, Watts GF, Burnett JR
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Simvastatin (mk 733) in Heterozygous Familial Hypercholesterolemia - a 2-year Trial

, 1989
Simvastatin (MK 733), a new competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, given in daily doses of 20 mg and 40 mg for 104 weeks, has been shown to lower the serum total cholesterol and low density lipoprotein cholesterol level
Harvengt, C., Leclercq, V.
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Obicetrapib in patients with heterozygous familial hypercholesterolemia: the BROOKLYN randomized clinical trial

Most patients with heterozygous familial hypercholesterolemia fail to achieve adequate low-density lipoprotein (LDL) cholesterol lowering. Here we carried out a randomized trial to test the safety and efficacy of obicetrapib, a highly selective ...
Balinskaite, Violeta, Banach, Maciej, Goldberg, Anne C, Davidson, Michael H, Kling, Douglas, Kastelein, John JP, Szarek, Michael, Nissen, Steven E, Nelson, Adam J, Ray, Kausik K, Navar, Ann Marie, Ballantyne, Christie M, Wuerdeman, Erin, Catapano, Alberico L, Neild, Annie L, Brunham, Liam R, Butters, Julie, Ditmarsch, Marc, Nicholls, Stephen J, Hsieh, Andrew, Laufs, Ulrich, Mehran, Roxana, Ference, Brian A   +22 more
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AN INTERESTING CASE OF FAMILIAL HOMOZYGOUS HYPERCHOLESTEROLEMIA , SFH RIYADH KSA.

, 2017
Familial hypercholesterolemia is an inherited condition that cause high level of LDL and cholesterol levels beginning birth . Familial hypercholesterolemia is run in families in an autosomal manner .
Amjaad Al Marjan, Fawwaz Al Mutairi.
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Genetic and metabolic factors predicting risk of cardiovascular disease in familial hypercholesterolemia.

, 2001
Familial hypercholesterolemia is a hereditary metabolic disorder characterised by high low-density lipoprotein cholesterol levels and an extreme risk of premature cardiovascular disease.
Smilde, T.J., Wissen, S. van, Stalenhoef, A.F.H., Wollersheim, H.C.H., Kastelein, J.J.P., T Smilde   +5 more
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Compound Heterozygous Familial Hypercholesterolemia Detected by Cascade Screening

This report outlines the case of a 13-year-old non-Hispanic White male diagnosed with compound heterozygous Familial Hypercholesterolemia (FH) with a biallelic mutation in the LDLR gene.
Hamilton, Luke, Wilson, Don, Nagaram, Sumedha   +2 more
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Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine

We studied the effects of the bile acid sequestrant cholestyramine, alone and in combination with the experimental agent compactin (ML-236B), a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on serum levels of lipoproteins in ...
Mabuchi, Hiroshi, Watanabe, Akira, Yoshimura, Akira, Sakai, Takeshi, Koizumi, Junji, Takeda, Ryoyu, Sakai, Yasuyuki, Wakasugi, Takanobu   +7 more
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Mecanismos moleculares que relacionam a hipercolesterolemia familiar à doença de Alzheimer [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2015.A hipercolesterolemia familiar é uma doença do metabolismo das lipoproteínas causada por anormalidades ...
Oliveira, Jade de
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