Results 101 to 110 of about 30,028 (235)

Life Course Approach for Managing Familial Hypercholesterolemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Treatment of familial hypercholesterolemia is directed toward the moment of the medical encounter. However, risk for heart disease as a consequence of having familial hypercholesterolemia is related to lifelong exposure to elevated low‐density ...
Samuel S. Gidding, Dirk J. Blom, Brian McCrindle, Uma Ramaswami, Raul D. Santos, Gerald F. Watts, Albert Wiegman   +6 more
doaj   +1 more source

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

EBioMedicine, 2018
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait.
Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu   +14 more
doaj   +1 more source

Impact of Age on the Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia

Cardiovascular Drugs and Therapy, 2019
PurposeThis post-hoc analysis examined whether age modified the efficacy and safety of alirocumab, a PCSK9 inhibitor, in patients with heterozygous familial hypercholesterolemia (HeFH), using pooled data from four 78-week placebo-controlled phase 3 ...
H. Ginsberg, J. Tuomilehto, J. Tuomilehto, G. Hovingh, B. Cariou, R. Santos, Alan S. Brown, Santosh K. Sanganalmath, A. Koren, D. Thompson, F. Raal   +10 more
semanticscholar   +1 more source

Family heterozygous hypercholesterolemia: a case report

, 2019
Іntroduction: Familial hypercholesterolemia (FH) is an autosomal dominant disorder, caused by the defect of the gene, encoding the structure and function of the receptor for the apoprotein B/E. Patients with FH are predisposed to premature development of
Ждан, Вячеслав Миколайович, Бабаніна, Марина Юріївна, Babanina, M. Yu., Kitura, O. Ye., Кітура, Оксана Євгенівна, Zhdan, V. M., Kitura, Ye. M., Ткаченко, Максим Васильович, Tkachenko, M. V., Кітура, Євдокія Михайлівна   +9 more
core   +1 more source

Alirocumab—a novel drug for familial hypercholesterolemia

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Familial hypercholesterolemia (FH) is a genetically transmitted condition, wherein abnormally high levels of total cholesterol and low density lipoproteins (LDL) are seen.
Priyanka Kamath, Preethi J Shenoy
doaj   +1 more source

Long-term safety and efficacy of alirocumab in patients with heterozygous familial hypercholesterolemia: An open-label extension of the ODYSSEY program.

Atherosclerosis, 2018
BACKGROUND AND AIMS ODYSSEY OLE (open-label extension; NCT01954394) included patients diagnosed with heterozygous familial hypercholesterolemia (HeFH), receiving maximally tolerated statins, who had completed one of four Phase 3 double-blind parent ...
M. Farnier, G. Hovingh, G. Langslet, R. Dufour, M. Baccara-Dinet, C. Din-Bell, G. Manvelian, J. Guyton   +7 more
semanticscholar   +1 more source

Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The genetic and clinical factors influencing the rate of brain structure change in cognitive decline remain poorly understood. This study aimed to identify genetic variants and risk factors contributing to these changes and explore potential causal relationships.
Yin Jin, Apostolia Topaloudi, Petros Drineas, Peristera Paschou   +3 more
wiley   +1 more source

Brain Atrophy Associated With Risk Variant rs10191329 Extends Beyond Multiple Sclerosis

Annals of Neurology, Volume 99, Issue 4, Page 1083-1089, April 2026.
The risk allele rs10191329*A is associated with disease severity and brain atrophy in people with multiple sclerosis (MS). We investigated the association of rs10191329 with age‐related brain atrophy in a population‐based cohort using 10,308 magnetic resonance imaging (MRI) scans of 4,815 participants aged ≥ 45 years without MS in cross‐sectional and ...
Cato E. A. Corsten, Ana M. Marques, Elisabeth J. Vinke, C. Louk de Mol, Rinze F. Neuteboom, M. Kamran Ikram, Mohsen Ghanbari, Frank J. Wolters, Beatrijs Wokke, Meike W. Vernooij, Joost Smolders   +10 more
wiley   +1 more source

Phenotypic Variation in Heterozygous Familial Hypercholesterolemia

, 1998
—Familial hypercholesterolemia (FH) is caused by mutations in the LDL receptor (LDLR) gene and is usually associated with hypercholesterolemia, lipid deposition in tissues, and premature coronary artery disease (CAD).
Xi-Ming Sun, Jiri J. Frohlich, Simon N. Pimstone, Michael R. Hayden, Christele du Souich, Anne K. Soutar   +5 more
core   +1 more source

Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher

Cardiovascular Drugs and Therapy, 2016
PurposeEven with statins and other lipid-lowering therapy (LLT), many patients with heterozygous familial hypercholesterolemia (heFH) continue to have elevated low-density lipoprotein cholesterol (LDL-C) levels. ODYSSEY HIGH FH (NCT01617655) assessed the
H. Ginsberg, D. Rader, F. Raal, J. Guyton, M. Baccara-Dinet, C. Lorenzato, R. Pordy, E. Stroes   +7 more
semanticscholar   +1 more source