Results 161 to 170 of about 83,479 (285)
ATF4 promotes renal tubulointerstitial fibrosis through hexokinase II-mediated glycolysis. [PDF]
Feng S +10 more
europepmc +1 more source
A Roadmap for Breeding Sweet Tomatoes
This graphical abstract outlines four breeding strategies for enhancing sugar content and sweetness in tomato fruits: (1) Identification of key genes and functional variant loci regulating fruit sugar accumulation through systematic germplasm collection, genome‐wide association studies (GWAS), map‐based cloning, and reverse genetics approaches.
Jie Chen, Hongjun Lyu, Jinzhe Zhang
wiley +1 more source
Genistein-Butein Co-Treatment Suppresses Glycolytic Metabolism and Induces Apoptotic Signaling in PC-3 Prostate Cancer Cells. [PDF]
Cho MK, Lee Y, Lee SH, Nam HS, Lee YJ.
europepmc +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
USP30-mediated Deubiquitination of Hexokinase 2 controls the metabolic fate of glucose and tumor progression. [PDF]
Haowei Z +10 more
europepmc +1 more source
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Revisiting the Glucose Kinase Superfamily: From Origins to the Evolution of Metabolism. [PDF]
Jardim-Messeder D +2 more
europepmc +1 more source
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu +6 more
wiley +1 more source

