Results 231 to 240 of about 58,740 (306)

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys. [PDF]

Mol Biomed
Yu Z, Zhang Y, Bai X, Zhao J, Wei L, Gao J, Wu H, Ma R, Ning X, Sun S.   +9 more
europepmc   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

HKDC1-mediated polyamine rewiring drives lenvatinib resistance and immune escape in hepatocellular carcinoma. [PDF]

Clin Mol Hepatol
Chen S, Wang B, Zhang Y, Quan B, Shao Y, Zhu G, Cai J, Zhang P, Song L, Wan J, Yang Y, Du J, Cai Y, Dai Z.   +13 more
europepmc   +1 more source

Associations Between Metabolic Phenotypes and Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention: A Prospective Cohort Study

MedComm – Future Medicine, Volume 5, Issue 3, September 2026.
Among 23,882 PCI patients, metabolic phenotypes were classified as MHN, MHO, MUN, and MUO. During the 3‐year follow‐up, MUN was independently associated with higher cardiovascular risk compared with MHN (HR 1.27, 95% CI 1.07–1.52), mainly driven by MI and stroke. Metabolic phenotype stratification may improve risk assessment after PCI. ABSTRACT Obesity
Bowen Li, Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Zhiyong Zhao, Kefei Dou   +6 more
wiley   +1 more source

SLC Transporter-Mediated Functional Imaging in Cancer Diagnosis. [PDF]

Biomolecules
Zhang L, He J.
europepmc   +1 more source

Aged Mitochondrial DNA Is Associated With Aberrant Acute Exercise‐Induced Redox Responses in Human Skeletal Muscle

Aging Cell, Volume 25, Issue 9, September 2026.
Findings from this study suggest that aging is accompanied by altered skeletal muscle mitochondrial redox regulation and exercise responsiveness, with decreased mtDNA copy number, increased mtDNA mutation deletion frequency, and selective redox remodeling of key mitochondrial proteins representing potential contributors to these changes. ABSTRACT Redox
Bradley A. Ruple, Nicholas A. Carlini, Jason S. Kofoed, Helya Rostamkhani, Brady E. Hanson, Jesse C. Craig, Shelby C. Osburn, Allison M. Manuel, Paul A. Stewart, Jonathan Wanagat, Ryan M. Broxterman, Joel D. Trinity   +11 more
wiley   +1 more source

Resveratrol Inhibits Macrophage Glucose Metabolism Reprogramming and Inflammatory Activation to Delay COPD Progression Through the TLR4/HK2 Pathway. [PDF]

J Cell Physiol
Li Z, Zhang B, Li K, Yan J, Li N, Sun L, Zhao W.   +6 more
europepmc   +1 more source

Benzothiazepane‐Based Curcumin Analogs Show Selective Effects on Respiration, Permeability, and Growth of Gut‐Liver (Co‐Culture) Cell Models

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Benzothiazephane‐based curcuminoids are more potent than curcumin to inhibit liver cancer outgrowth in a Caco‐2/HepG2 coculture model, depending on methylation and heterocyclic substituent pattern. This may be the result of altered absorption, metabolism, and mitochondrial function, which are relevant targets for drug design.
Fuhua Li, Julie De Munck, Felien Morlion, Katarina Magdalenic, Andreja Rajkovic, Matthias D'hooghe, John Van Camp, Charlotte Grootaert   +7 more
wiley   +1 more source