Results 241 to 250 of about 58,740 (306)

Inositol biosynthesis is inversely regulated by glycolytic activity. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
Onu CJ, Adu M, Jabbar D, Ezumel E, Schmidtke MW, Saiardi A, Greenberg ML.   +6 more
europepmc   +1 more source

Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8103-8112, September 2026.
ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins, Sandhi M. Barreto, Lidyane V. Camelo, Sara T. Menezes, Naomi M. Hamburg, Maria de Fatima H. S. Diniz, Antonio L. P. Ribeiro, Luisa C. C. Brant   +7 more
wiley   +1 more source

Th17 cells favor migration and invasiveness of cervical cancer cells under hypoxia in an IGF2BP2-dependent manner. [PDF]

Int J Cancer
Gies S, Pohlers M, Tänzer T, Ampofo E, Laschke MW, Schäfer M, Kim YJ, Bohle RM, Solomayer EF, Wagner K, Empting M, Kiemer AK, Walch-Rückheim B.   +12 more
europepmc   +1 more source

Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70–Hsp110 chaperone system

The FEBS Journal, Volume 293, Issue 18, Page 5541-5557, September 2026.
Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff, Paolo De Los Rios, Mathieu E. Rebeaud   +2 more
wiley   +1 more source

Pentose Phosphate Pathway Is Critical for Providing Energy by Bypassing 6-Phosphofructo-1-Kinase (PFK1) During Increased Neuronal Activity. [PDF]

Metabolites
Kristian T, Waddell J, McKenna MC.
europepmc   +1 more source

Prmt6 Deficiency Drives Osteoblast Senescence Promoting Age‐Related Osteoporosis via Epigenetic Remodelling of the H3R2me2a/Sting/Ifitm3 Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Protein arginine methyltransferase 6 (Prmt6), an epigenetic regulator, plays an unclear role in bone homeostasis and osteoblast senescence. In this study, we employed Western blot, qPCR, immunofluorescence, SA‐β‐Gal staining, and RNA‐seq to systematically investigate the regulatory mechanism of the Prmt6/H3R2me2a/Sting/Ifitm3 axis in ...
Yuxue Wang, Xiaoyong Ge, Shengjie Chang, Diankai Wang, Ke Xu, Haowei Xu, Xiaowei Liu, Shanjin Wang   +7 more
wiley   +1 more source

Hexokinase 2 upregulation is associated with glycolytic reprogramming and neuroinflammation in hypoxic-ischemic brain damage: a therapeutic target for early intervention. [PDF]

Front Immunol
Li Y, Qin C, Miao C, Mu R, Zhang P, Zhang B, Zhao X, Zhang X.   +7 more
europepmc   +1 more source

Associations of finerenone with reduced insulin resistance in patients with type 2 diabetes and chronic kidney disease: A real‐world observational study

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1524-1532, September 2026.
This real‐world observational study enrolled 256 patients with type 2 diabetes and chronic kidney disease (T2D‐CKD). After 12 months of finerenone treatment, 45 patients completed follow‐up. Finerenone was associated with significant improvements in insulin resistance markers (HOMA‐IR, TyG index), lipid profile (LDL‐C), glycemic control (HbA1c), and ...
Xin Zhao, Bohan Liu, Ran Sun, Yaxuan Shi, Ya Liu   +4 more
wiley   +1 more source

Targeting SRC/STAT3 Signaling Impairs Cancer Stem Cell Activity by Downregulation of Hexokinase-2 in Radioresistant Triple-Negative Breast Cancer Cells. [PDF]

Oncol Res
Huang YH, Tu YC, Chien PJ, Lee AJ, Lin CL, Li ST, Lee YC, Chang WW.   +7 more
europepmc   +1 more source

Association between cardiometabolic risk factors cluster and all‐cause mortality in type 2 diabetes

Journal of Diabetes Investigation, Volume 17, Issue 9, Page 1557-1564, September 2026.
ABSTRACT Objective To investigate the association between the cardiometabolic risk factors cluster (CRFC) and all‐cause mortality in type 2 diabetes (T2D). Methods Data from the Zhejiang Rural T2D Cohort (2016–2024) included 10,310 participants. Four cardiometabolic risk factors (CRFs) were evaluated: central obesity, elevated blood pressure, high ...
Qingfang He, Hongting Zhu, Yong Wang, Xiaoyan Zhou, Yuting Han, Ruying Hu   +5 more
wiley   +1 more source