Results 21 to 30 of about 1,606 (180)

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

Human adenovirus type 7 subunit vaccine induces dendritic cell maturation through the TLR4/NF-κB pathway is highly immunogenic

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionHuman adenovirus type 7 (HAdv-7) infection is the main cause of upper respiratory tract infection, bronchitis and pneumonia in children. At present, there are no anti- adenovirus drugs or preventive vaccines in the market.
Yaru Li, Yaru Li, Xia Yang, Renshuang Zhao, Zhiru Xiu, Shanzhi Li, Yue Li, Gaojie Song, Chenchen Ge, Jinbo Fang, Jicheng Han, Yilong Zhu, Yiquan Li, Yiquan Li   +13 more
doaj   +1 more source

Adenoviruses in Fecal Samples from Asymptomatic Rhesus Macaques, United States

Emerging Infectious Diseases, 2012
Adenoviruses can cause infectious diarrheal disease or respiratory infections in humans; 2 recent reports have indicated probable human infection with simian adenoviruses (SAdVs).
Soumitra Roy, Arbansjit Sandhu, Angelica Medina, David S. Clawson, James M. Wilson   +4 more
doaj   +1 more source

Binding of FX and FII to Ad5 vectors, hexon-chimeric Ad5 vectors, and vectors with mutations in hexon HVR7.

, 2022
(A) Binding affinities of FX and FII for Ad5 vectors with wild-type Ad5 capsid (Ad5.0) or vectors with various alterations in Ad5 hexon. SPR plots are presented in S1 Fig. (B) Binding affinities of FX and FII for Ad5 vectors with chimeric hexon from Ad1,
Jie Tian (20496), Philip Ng (265455), Donna J. Palmer (13864205), Andrew P. Byrnes (13864208), Zhili Xu (341008), Rituparna Moitra (4822002)   +5 more
core   +1 more source

Conflicting Evidence between Clinical Perception and Molecular Epidemiology: The Case of Fowl Adenovirus D

Animals, 2023
Fowl adenoviruses (FAdVs, species FAdV-A/-E) are responsible for several clinical syndromes reported with increasing frequency in poultry farms in the last decades.
Giovanni Franzo, Giulia Faustini, Claudia Maria Tucciarone, Daniela Pasotto, Matteo Legnardi, Mattia Cecchinato   +5 more
doaj   +1 more source

Comparative Sequence Analysis, Pathogenicity and Immunogenicity of Attenuated Fowl Adenovirus Isolates as Experimental Vaccines against Inclusion Body Hepatitis of Commercial Broiler Chickens

Vaccine Research, 2021
Introduction: Fowl adenoviruses (FAdV) cause inclusion body hepatitis (IBH) in chickens and new vaccination strategies against IBH are needed as an effective control measure in the poultry industry. Methods: The attenuated FAdV isolates from from chicken
NORFITRIAH MOHAMED SOHAIMI, Mohd Hair-Bejo   +1 more
doaj   +1 more source

Detection and Molecular Characterization of Adenoviruses in Captive and Free-Roaming African Green Monkeys (Chlorocebus sabaeus): Evidence for Possible Recombination and Cross-Species Transmission

Viruses, 2023
In the present study, 31 samples (12 fecal, 9 nasal and 10 rectal swabs) from 28/92 (30.43%, 10 captive and 18 free-roaming African green monkeys (AGMs, Chlorocebus sabaeus)) apparently healthy AGMs in the Caribbean Island of St.
Diana M. Mancuso, Kerry Gainor, Kerry M. Dore, Christa A. Gallagher, Katalina Cruz, Amy Beierschmitt, Yashpal S. Malik, Souvik Ghosh   +7 more
doaj   +1 more source

Comparison of Liver Detargeting Strategies for Systemic Therapy with Oncolytic Adenovirus Serotype 5

Biomedicines, 2017
Oncolytic viruses would ideally be of use for systemic therapy to treat disseminated cancer. To do this safely, this may require multiple layers of cancer specificity.
Tien V. Nguyen, Mary E. Barry, Mallory A. Turner, Catherine M. Crosby, Miguel A. Trujillo, John C. Morris, Michael A. Barry   +6 more
doaj   +1 more source

Data_Sheet_3_Immunological Study of Reconstructed Common Ancestral Sequence of Adenovirus Hexon Protein.xlsx

, 2021
Aim: To reconstruct the ancestral sequence of human adenoviral hexon protein by combining sequence variations and structural information. And to provide a candidate hexon protein for developing new adenoviral vector capable of escaping the pre-existing ...
Xiqiao Du (6011789), Ya Gao (526722), Weiyuan Guo (6011795), Zhangyi Qu (381563), Yingchen Wang (6011777), Hong Gao (68166), Falong Li (11611150), Lei Shang (158397), Guiyun Qi (6011780), Zhe Zhang (81603), Tuo Dong (381566)   +10 more
core   +1 more source

Hexon-based scaffold for generation of diagnostic monoclonal antibodies against diverse adenovirus types

Инфекция и иммунитет, 2019
Infectious diseases hold one of the most crucial places in healthcare. In Russia, annual prevalence of infectious diseases comprises around 50 million cases, wherein acute respiratory viral infections cover up to 90%.
T. A. Timoshicheva, Ya. A. Zabrodskaya, I. V. Amosova   +2 more
doaj   +1 more source