Results 121 to 130 of about 810 (162)

Selected modification of the adenovirus type 5 hexon modulates interaction with coagulation factor X and hepatocyte transduction in vivo

, 2009
Recent studies have demonstrated the fundamental role of coagulation factors in adenovirus infectivity in vivo. It has been shown that coagulation factor X (FX) binds to the hypervariable regions (HVR) of the adenovirus serotype 5 (Ad5) hexon with high ...
Barouch, D. H., MacVey, John H., Baker, Andrew H., Goudsmit, J., Alba, R., Parker, Alan L., Bhella, D., Nicklin, Stuart A., Waddington, Simon N., Bradshaw, Angela C., Custers, Jerome, Van Rooijen, Nico   +11 more
core  

10. A Fundamental Role for the Adenovirus Serotype 5 Hexon in Liver Gene Transfer

Molecular Therapy, 2008
openaire   +1 more source

MOLECULAR ANALYSIS OF HEXON AND FIBER GENES OF FOWL AVIADENOVIRUSES ISOLATED FROM FIELD CASES OF INCLUSION BODY HEPATITIS

The Journal of Animal and Plant Sciences, 2023
openaire   +1 more source

Helper dependent adenoviral vectors for gene therapy of hyperlipidemias

, 2008
Astone, Dalila
core  

Hexon gene based molecular detection of fowl adenovirus associated inclusion body hepatitis in commercial broiler chicken

International Journal of Advanced Biochemistry Research
Rakesh Sharma, Mohan Singh Thakur, Bikas R Prusty, Anju Nayak, Sanjay Shukla, Kajal K Jadav, Kush Shrivastav, Tripti Jain, Ankur Singh   +8 more
openaire   +1 more source

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer [PDF]

Cell, 2008
Adenoviruses are used extensively as gene transfer agents, both experimentally and clinically. However, targeting of liver cells by adenoviruses compromises their potential efficacy. In cell culture, the adenovirus serotype 5 fiber protein engages the coxsackievirus and adenovirus receptor (CAR) to bind cells.
Simon N Waddington, John H Mcvey, David Bhella   +2 more
exaly   +7 more sources

Genomic characterization of a novel human adenovirus type 31 recombinant in the hexon gene

Journal of General Virology, 2011
A novel human recombinant adenovirus of species A (HAdV-A31 MZ) was isolated from a patient with acute gastroenteritis in Japan. The complete genome of HAdV-A31 strain MZ contains 33 776 bp. Analysis of the hexon gene of HAdV-A31 MZ indicated that its hexon sequence is the result of a genetic recombination between those of HAdV-A31 and a close relative
Tung Gia Phan, Hiroshi Ushijima
exaly   +4 more sources

DNA Sequence of the Adenovirus Type 41 Hexon Gene and Predicted Structure of the Protein

Journal of General Virology, 1988
The gene for the major capsid protein (hexon) of human adenovirus type 41 (Ad41) has been isolated and the complete DNA sequence determined. Comparison of the predicted amino acid sequence with hexons from human Ad2 and Ad5 and bovine adenovirus type 3 reveals regions of high homology at the N and C termini separated by a central region of low homology.
Ronald T HAY
exaly   +3 more sources

Retargeting of gene expression using endothelium specific hexon modified adenoviral vector

Virology, 2013
Adenovirus serotype 5 (Ad5) vectors are well suited for gene therapy. However, tissue-selective transduction by systemically administered Ad5-based vectors is confounded by viral particle sequestration in the liver. Hexon-modified Ad5 expressing reporter gene under transcriptional control by the immediate/early cytomegalovirus (CMV) or the Roundabout 4
Cecil R Stockard, William E Grizzle, Jeffrey M Arbeit   +2 more
exaly   +3 more sources

Identification of Group I-III Avian Adenovirus by PCR Coupled with Direct Sequencing of the Hexon Gene

Journal of Veterinary Medical Science, 2009
Polymerase chain reaction (PCR) coupled with direct sequencing of the product of the hexon gene was applied to avian adenoviruses (formerly group I-III). The expected sizes of DNA fragments were successfully amplified by PCR from all of the group I-III avian adenoviruses with our designed primers.
Masaji Mase, Hiromichi Mitake, Tadao Imada   +2 more
exaly   +4 more sources