Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene. [PDF]
PLoS ONE, 2011 In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea.
Elizabeth B Liu +10 more
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Tropism-Modification Strategies for Targeted Gene Delivery Using Adenoviral Vectors [PDF]
Viruses, 2010 Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Andrew H. Baker +6 more
doaj +2 more sources
Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4 [PDF]
Emerging Microbes and Infections, 2018 Since May 2015, outbreaks of hydropericardium-hepatitis syndrome (HHS) caused by fowl adenovirus 4 (FAdV-4) with a novel genotype have been reported in China, causing significant economic losses to the poultry industry.
Yuhan Zhang +9 more
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Unveiling the role of hexon-associated host proteins in fowl adenovirus serotype 4 replication [PDF]
Frontiers in Veterinary ScienceFowl adenovirus serotype 4 (FAdV-4), a member of the family Adenoviridae and the genus Aviadenovirus, is responsible for a significant number of emerging diseases that cause substantial economic losses in the poultry industry worldwide. The hexon protein
Xiaojun Zhang +4 more
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Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies [PDF]
Virology Journal, 2017 Background Adenoviruses are common pathogens infecting animals and humans. They are classified based on serology, or genome sequence information. These methods have limitations due to lengthy procedures or lack of infectivity data.
Martin Pacesa +5 more
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Identification and Application of Neutralizing Epitopes of Human Adenovirus Type 55 Hexon Protein
Viruses, 2015 Human adenovirus type 55 (HAdV55) is a newly identified re-emergent acute respiratory disease (ARD) pathogen with a proposed recombination of hexon gene between HAdV11 and HAdV14 strains.
Xingui Tian +7 more
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Journal of Medical Virology, 2016 Human adenoviruses (HAdVs) are common causes of conjunctivitis. This study describes the epidemiological features and characterizes by phylogenetic analysis HAdVs isolated from patients with conjunctivitis in Tunisia, North Africa. Data on out‐patients presenting with conjunctivitis during 2 years (2012–2013) were analyzed.
Nadia, Fedaoui +6 more
core +4 more sources
Overreliance on the Hexon Gene, Leading to Misclassification of Human Adenoviruses [PDF]
Journal of Virology, 2012 ABSTRACT The genome of human adenovirus (HAdV) D30 was sequenced in depth. Sequence assembly and analysis revealed two distinct viral sequences with identical hexon genes, which were the same as the one previously reported for HAdV-D30. However, one of the two viruses was found to be a recombinant of HAdV-D29.
Gurdeep, Singh +7 more
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Molecular Therapy: Methods & Clinical Development, 2022 In adenovirus type 5 (HAdV-5)-derived viral vectors, the fiber protein has been the preferred locale for modifications to alter the natural viral tropism.
Robin Nilson +9 more
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The gene for the adenovirus 2 hexon polypeptide.
Journal of Biological Chemistry, 1984 The nucleotide sequence of the gene for the adenovirus type 2 hexon has been determined. The hexon polypeptide consists of 967 amino acid residues and has a molecular weight of 109,058. Several tentative parts in the previously reported amino acid sequence were resolved from the DNA sequence.
G, Akusjärvi +5 more
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