Results 31 to 40 of about 5,015 (194)
Deep-sea Hydrothermal Vent Bacteria as a Source of Glycosaminoglycan-Mimetic Exopolysaccharides
Molecules, 2019 Bacteria have developed a unique strategy to survive in extreme environmental conditions through the synthesis of an extracellular polymeric matrix conferring upon the cells a protective microenvironment.
Agata Zykwinska +5 more
doaj +1 more source
Determinación de hexosamines en orina por HPLC para el diagnóstico de mucopolisacariosis tipo III [PDF]
, 2014 Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2014, Tutors: Dra. Elisabet Fuguet Jordà i Dr. Rafael Artuch IriberriIn the present work a reported analytical method was optimized in order to improve the ...
Zamora Campos, Nelson
core
Fibroblast Plasticity in Inflammation of the Barrier
Barrier Immunity, EarlyView.Under inflammatory condition, fibroblasts in barrier tissues integrate inflammatory, senescent, and mechanical inputs. These pathways activate central signaling networks to drive fibroblast phenotypic transition, enabling cytokine production, immune cell recruitment, and extracellular matrix remodeling.
Chen Zhang, Hao Wu, Wei Li
wiley +1 more source
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases
Exploration, EarlyView.This review explores the critical role of mitochondria in heart development and cardiovascular disease. It highlights how mitochondrial maturation during embryonic‐to‐postnatal transition, regulated by oxygen and metabolic changes, shapes cardiac structure and function.
Minghao Li +3 more
wiley +1 more source
An abyssal hill fractionates organic and inorganic matter in deep-sea surface sediments [PDF]
, 2015 Current estimates suggest that more than 60% of the global seafloor are covered by millions of abyssal hills and mountains. These features introduce spatial fluid-dynamic granularity whose influence on deep-ocean sediment biogeochemistry is unknown. Here
Aller R. C. +8 more
core +1 more source
Glutamine deprivation triggers NAGK-dependent hexosamine salvage [PDF]
eLife, 2020 AbstractTumors frequently exhibit aberrant glycosylation, which can impact cancer progression and therapeutic responses. The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a major substrate for glycosylation in the cell.
Sydney L. Campbell +12 more
openaire +3 more sources
Berberine alleviates cell pyroptosis in diabetic retinopathy by regulating AKT1, JUN, and STAT3
Ibrain, EarlyView.Berberine alleviates diabetic retinopathy by reducing pyroptosis through AKT1/JUN/STAT3 regulation, as validated in rat models via network pharmacology, molecular docking, and experimental assays. Abstract Berberine (BBR) exerts an effective protection for diabetic retinopathy (DR), but the underlying key molecular mechanism remains unknown; this study
Na Li +7 more
wiley +1 more source
Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses.
PLoS ONE, 2020 β-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing β-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal storage disorders
Catlyn Cavender +8 more
doaj +1 more source
Insulin Resistance: From Theory To Practice [PDF]
, 2006 Insulin resistance is at the core of the well recognised metabolic syndrome and possibly many other ailments commonly seen in the modern society. While the quantification of insulin resistance remains a difficult task, the problems associated with it are
Kakkilaya Bevinje, Dr. Srinivas
core +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source