Results 41 to 50 of about 7,225 (221)

Interaction between human mucins and parasite glycoproteins: the role of lectins and glycosidases in colonization by intestinal protozoa

Revista do Instituto de Medicina Tropical de São Paulo, 2020
Intestinal mucins are the first line of defense against microorganisms. Although knowledge about the mechanisms involved in the establishment of intestinal protozoa is limited, there is evidence that these parasites produce lectin-like molecules and ...
Joel Martínez-Ocaña, Pablo Maravilla, Angélica Olivo-Díaz   +2 more
doaj   +1 more source

Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation [PDF]

, 2016
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-β ...
A. John, Abbott, Bojanova, Bäckhed, C. Roth, Cekic, Copley, Darby, Dennis, Drouillard, E. D. Goddard-Borger, Falk, G. J. Davies, Goldman, He, Hemsworth, Knapp, Korczynska, Krissinel, Lai, Larsbrink, Larsbrink, M. Petricevic, Macauley, Macdonald, Mark, Noach, Pudlo, Robb, Ruseler-van Embden, S. J. Williams, Sumida, Sumida, Terrapon, Vocadlo, White, Whitworth, Williams   +37 more
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Glycosidases during chick embryo lung development and their colocalization with proteoglycans and growth factors

European Journal of Histochemistry, 2009
During development, the epithelial component of the lung goes through a complex orderly process of branching, following strict patterns of space and time.
G Stabellini, M Calvitti, T Baroni, L Marinucci, C Calastrini, P Carinci, E Becchetti   +6 more
doaj   +1 more source

Bifidobacterium mongoliense genome seems particularly adapted to milk oligosaccharide digestion leading to production of antivirulent metabolites

BMC Microbiology, 2020
Background Human milk oligosaccharides (HMO) could promote the growth of bifidobacteria, improving young children’s health. In addition, fermentation of carbohydrates by bifidobacteria can result in the production of metabolites presenting an ...
Pauline Bondue, Christian Milani, Emilie Arnould, Marco Ventura, Georges Daube, Gisèle LaPointe, Véronique Delcenserie   +6 more
doaj   +1 more source

Acid-catalysed carboxymethylation, methylation and dehydration of alcohols and phenols with dimethyl carbonate under mild conditions [PDF]

, 2016
Dimethyl carbonate (DMC) chemistry has been extended to include acid-catalysed reactions of different aliphatic alcohols and phenols. For the first time, p-toluenesulfonic acid (PTSA), H2SO4, AlCl3 and FeCl3 have been shown to aid carboxymethylation for ...
Clark, James H., Hunt, Andrew J., Jin, Saimeng, McElroy, Con Robert   +3 more
core   +1 more source

Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases [PDF]

, 2016
The industrial conversion of cellulosic plant biomass into useful products such as biofuels is a major societal goal. These technologies harness diverse plant degrading enzymes, classical exo- and endo-acting cellulases and, increasingly, cellulose ...
Agirre, Agirre, Agrawal, Ask, Bacik, Barlow, Berlin, Bohlin, Bohlin, Bruno, Cannella, Cota, Cremer, Davies, Davies, Davies, Emsley, Engh, Evans, Gilbert, Harris, Henrissat, Himmel, Horn, Hudson, Imberty, Joosten, Karkehabadi, Kim, Krissinel, Krissinel, Kumar, Langston, Lima, Lombard, McNicholas, Murshudov, Pei, Pozzo, Quinlan, Ragauskas, Robinson, Rojas, Singhania, Stubbs, Suzuki, Sørensen, Thongpoo, Vagin, Vagin, Varghese, Vocadlo, Winn, Wirawan, Xin, Yoshida   +55 more
core   +2 more sources

Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars [PDF]

, 2022
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions from the respective azido/aminohexylpyrrolidine iminosugar precursors.
Bojarová, Pavla, Carmona Asenjo, Ana Teresa, Kulik, Natalia, Křen, Vladimír, Martínez Bailén, Macarena, Moreno Vargas, Antonio José, Mészáros, Zuzana, Pingitore, Valeria, Robina Ramírez, Inmaculada, Slámová, Kristýna   +9 more
core   +2 more sources

Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease

Journal of Lipid Research, 2017
Drug-induced phospholipidosis (DIPL) is characterized by an increase in the phospholipid content of the cell and the accumulation of drugs and lipids inside the lysosomes of affected tissues, including in the liver.
Emmanuelle Lecommandeur, David Baker, Timothy M. Cox, Andrew W. Nicholls, Julian L. Griffin   +4 more
doaj   +1 more source

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families

BMC Medical Genetics, 2019
Background Neurological disorders are a common cause of morbidity and mortality within Pakistani populations. It is one of the most important challenges in healthcare, with significant life-long socio-economic burden. Methods We investigated the cause of
Shazia Khan, Lettie E. Rawlins, Gaurav V. Harlalka, Muhammad Umair, Asmat Ullah, Shaheen Shahzad, Muhammad Javed, Emma L. Baple, Andrew H. Crosby, Wasim Ahmad, Asma Gul   +10 more
doaj   +1 more source