Results 31 to 40 of about 24,501 (221)

HFE variants in colorectal cancer and their clinicopathological correlations.

, 2021
BACKGROUND: The study aimed to screen mutation of human homeostatic iron regulator (HFE) in colorectal carcinoma (CRC) and detect their associations with clinicopathological parameters.
Lee, Katherine TW, Cheng, Tracie, Ranaweera, Chamath D, Gopalan, Vinod, Islam, Farhadul, Lu, Cu T, Lam, Alfred K, Aktar, Sharmin, Gamage, Sujani MK, Dissabandara, Lakal   +9 more
core   +1 more source

A family of weak keys in HFE and the corresponding practical key-recovery

Journal of Mathematical Cryptology, 2012
The HFE (hidden field equations) cryptosystem is one of the most interesting public-key multivariate schemes. It has been proposed more than 10 years ago by Patarin and seems to withstand the attacks that break many other multivariate schemes, since ...
Bouillaguet Charles, Fouque Pierre-Alain, Joux Antoine, Treger Joana   +3 more
doaj   +1 more source

Cell-specific expression of Hfe determines the outcome of Salmonella enterica serovar Typhimurium infection in mice

Haematologica, 2020
Mutations in HFE cause hereditary hemochromatosis type I hallmarked by increased iron absorption, iron accumulation in hepatocytes and iron deficiency in myeloid cells.
Manfred Nairz, Christoph Metzendorf, Maja Vujic-Spasic, Anna-Maria Mitterstiller, Andrea Schroll, David Haschka, Alexander Hoffmann, Laura von Raffay, Richard Sparla, Christian W. Huck, Heribert Talasz, Patrizia L. Moser, Martina U. Muckenthaler, Günter Weiss   +13 more
doaj   +1 more source

Inverting HFE Is Quasipolynomial [PDF]

, 2006
In the last ten years, multivariate cryptography has emerged as a possible alternative to public key cryptosystems based on hard computational problems from number theory. Notably, the HFE scheme [17] appears to combine efficiency and resistance to attacks, as expected from any public key scheme.
Louis Granboulan, Antoine Joux, Jacques Stern   +2 more
openaire   +1 more source

Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. [PDF]

PLoS ONE, 2012
Nonsense-mediated decay (NMD) is an mRNA surveillance pathway that selectively recognizes and degrades defective mRNAs carrying premature translation-termination codons.
Rute Martins, Daniela Proença, Bruno Silva, Cristina Barbosa, Ana Luísa Silva, Paula Faustino, Luísa Romão   +6 more
doaj   +1 more source

Microgels Enable iPSCs to Assemble, Expand, and Differentiate Into Organoids—From Sizable to High‐Throughput

Advanced Materials, EarlyView.
A chemically defined PEG‐based microgel platform enables scalable, reproducible production of three‐dimensional microgel‐iPSC constructs in multiple sizes. The system is compatible with high‐throughput automation and supports human iPSC expansion and differentiation within a single construct, including directed differentiation into cardiac organoids ...
Laura Klasen, Matthias Mork, Ramin Nasehi, Vasudha Turuvekere Krishnamurthy, Kira Zeevaert, Aaron Babendreyer, Jacopo Di Russo, Wolfgang Wagner, Laura De Laporte   +8 more
wiley   +1 more source

The exploring of growth differentiation factor-15 and H63D gene polymorphisms in β-thalassemia major: Implications for cardiovascular risk and iron overload

Journal of Applied Hematology
BACKGROUND: β-thalassemia major (βTM) is a genetic disorder characterized by a deficiency in hemoglobin production, ineffective erythropoiesis, chronic hemolysis, lifelong blood transfusions, iron overload, and increased risk of cardiac complications ...
Hussein Yaqoub Hamza, Ahmed Ghdhban Al-Ziaydi, Aalan Hadi Hassan Alzamili   +2 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Liver disorder and the HFE locus [PDF]

QJM, 2001
Hereditary haemochromatosis (HH) is the most common inherited disease in Northern Europeans, with a prevalence of around 1 in 300.1 When Feder et al . identified a mutation in a novel MHC‐class‐I‐like gene, HFE , that was present in over 80% of these patients, it was evident that there was potential to improve not only patient diagnosis, but also the ...
S F, Stewart, C P, Day
openaire   +2 more sources

Differential HFE gene expression is regulated by alternative splicing in human tissues. [PDF]

PLoS ONE, 2011
The pathophysiology of HFE-derived Hereditary Hemochromatosis and the function of HFE protein in iron homeostasis remain uncertain. Also, the role of alternative splicing in HFE gene expression regulation and the possible function of the corresponding ...
Rute Martins, Bruno Silva, Daniela Proença, Paula Faustino   +3 more
doaj   +1 more source