Results 21 to 30 of about 24,501 (221)
Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex
Molecules, 2022 The protein HFE (homeostatic iron regulator) is a key regulator of iron metabolism, and mutations in HFE underlie the most frequent form of hereditary haemochromatosis (HH-type I). Studies have shown that HFE interacts with transferrin receptor 1 (TFR1),
Daniela Goncalves Monteiro +8 more
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Nuclear Engineering and Technology, 2022 Human failure event (HFE) dependency analysis is a part of human reliability analysis (HRA). For efficient HFE dependency analysis, a maximum number of minimal cut sets (MCSs) that have HFE combinations are generated from the fault trees for the ...
Woo Sik Jung +3 more
doaj +1 more source
The role of iron in viral infections
Frontiers in Bioscience-Landmark, 2020 Crucial cellular processes such as DNA synthesis and the generation of ATP require iron. Viruses depend on iron in order to efficiently replicate within living host cells.
Sophie Marion Schmidt
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The polymorphic locus rs1799945 of the HFE gene determines the risk of severe preeclampsia
Гинекология, 2023 Background. Preeclampsia (PE) is a gestation complication that affects not only maternal and perinatal mortality but also the quality of life of women who have undergone PE, as well as their children in later life, which determines the urgency and ...
Maria Yu. Abramova +5 more
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Biochemical, Biophysical, and Cellular Investigations of the Interactions of Transferrin Receptor with Transferrin and the Hereditary Hemochromatosis Protein, HFE [PDF]
, 2004 Hereditary hemochromatosis (HH) is a prevalent genetic disorder that results in the daily excess absorption of dietary iron. If untreated this disease leads to systemic organ failure and death. HH is caused by mutations to the gene coding for a protein
Giannetti, Anthony Michael
core +1 more source
Analysis of single nucleotide variants of HFE gene and association to survival in The Cancer Genome Atlas GBM data. [PDF]
PLoS ONE, 2017 Human hemochromatosis protein (HFE) is involved in iron metabolism. Two major HFE polymorphisms, H63D and C282Y, have been associated with an increased risk of cancers. Previously, we reported decreased gender effects in overall survival based on H63D or
Sang Y Lee +7 more
doaj +1 more source
Analysis of HFE And Non-HFE Gene Mutations in Brazilian Patients with Hemochromatosis [PDF]
Clinics, 2009 Approximately one-half of Brazilian patients with hereditary hemochromatosis (HH) are neither homozygous for the C282Y mutation nor compound heterozygous for the H63D and C282Y mutations that are associated with HH in Caucasians. Other mutations have been described in the HFE gene as well as in genes involved in iron metabolism, such as transferrin ...
Bittencourt, Paulo Lisboa +5 more
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Impact of HFE variants and sex in lung cancer.
PLoS ONE, 2019 The homeostatic iron regulator protein HFE is involved in regulation of iron acquisition for cells. The prevalence of two common HFE gene variants (H63D, C282Y) has been studied in many cancer types; however, the impact of HFE variants, sex and HFE gene ...
Sang Y Lee +5 more
doaj +1 more source
HFE-Related Hemochromatosis in a Chinese Patient: The First Reported Case
Frontiers in Genetics, 2020 HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry.
Wei Zhang +28 more
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HFE-Associated Hereditary Haemochromatosis [PDF]
Canadian Journal of Gastroenterology, 2000 Hereditary hemochromatosis is a common inherited disorder of the iron metabolism. Screening studies indicate that it has a prevalence of one in 200 to 400, depending on the population studied, and a carrier rate of about one in seven to one in 10. Feder et al identified the hereditary hemochromatosis gene (HFE) in 1996 and two candidate mutations; the ...
Eijkelkamp, E. J. +2 more
openaire +6 more sources