Models of Hfq interactions with small non-coding RNA in Gram-negative and Gram-positive bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Hfq is required by many Gram-negative bacteria to chaperone the interaction between small non-coding RNA (sRNA) and mRNA to facilitate annealing. Conversely and despite the presence of Hfq in many Gram-positive bacteria, sRNAs in Gram-positive bacteria ...
Derrick Watkins, Dev Arya
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Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure [PDF]
Communications Biology, 2023 Hfq is a pleitropic actor that serves as stress response and virulence factor in the bacterial cell. To execute its multiple functions, Hfq assembles into symmetric torus-shaped hexamers.
Mélanie Berbon +8 more
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Role of the Bacterial Amyloid-like Hfq in Fluoroquinolone Fluxes. [PDF]
Microorganisms, 2023 Due to their two-cell membranes, Gram-negative bacteria are particularly resistant to antibiotics. Recent investigations aimed at exploring new target proteins involved in Gram-negative bacteria adaptation helped to identify environmental changes ...
Turbant F +6 more
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The
BMC Microbiology, 2010 Background The bacterial Hfq protein is able to interact with diverse RNA molecules, including regulatory small non-coding RNAs (sRNAs), and thus it is recognized as a global post-transcriptional regulator of gene expression. Loss of Hfq has an extensive
Jiménez-Zurdo José I +7 more
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Transcriptome-scale analysis uncovers conserved residues in the hydrophobic core of the bacterial RNA chaperone Hfq required for small regulatory RNA stability [PDF]
Nucleic Acids ResThe RNA chaperone Hfq plays crucial roles in bacterial gene expression and is a major facilitator of small regulatory RNA (sRNA) action. The toroidal architecture of the Hfq hexamer presents three well-characterized surfaces that allow it to bind sRNAs ...
McQuail J +10 more
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Global Hfq-mediated RNA interactome of nitrogen starved Escherichia coli uncovers a conserved post-transcriptional regulatory axis required for optimal growth recovery. [PDF]
Nucleic Acids Res, 2023 The RNA binding protein Hfq has a central role in the post-transcription control of gene expression in many bacteria. Numerous studies have mapped the transcriptome-wide Hfq-mediated RNA–RNA interactions in growing bacteria or bacteria that have entered ...
McQuail J +7 more
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The RNA chaperone Hfq is important for growth and stress tolerance in Francisella novicida. [PDF]
PLoS ONE, 2011 The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis.
Jacob R Chambers, Kelly S Bender
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The Pleiotropic Phenotypes Caused by an hfq Null Mutation in Vibrio harveyi
Microorganisms, 2023 Hfq is a global regulator and can be involved in multiple cellular processes by assisting small regulatory RNAs (sRNAs) to target mRNAs. To gain insight into the virulence regulation of Hfq in Vibrio harveyi, the hfq null mutant, ∆hfq, was constructed in
Yiqin Deng +5 more
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Hfq is a global regulator that controls the pathogenicity of Staphylococcus aureus. [PDF]
PLoS ONE, 2010 The Hfq protein is reported to be an RNA chaperone, which is involved in the stress response and the virulence of several pathogens. In E. coli, Hfq can mediate the interaction between some sRNAs and their target mRNAs.
Yu Liu +7 more
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eLife, 2021 RNA-binding proteins play myriad roles in regulating RNAs and RNA-mediated functions. In bacteria, the RNA chaperone Hfq is an important post-transcriptional gene regulator.
Seongjin Park +8 more
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