Involvement of the post-transcriptional regulator Hfq in Yersinia pestis virulence. [PDF]
PLoS ONE, 2009 BACKGROUND:Yersinia pestis is the causative agent of plague, which is transmitted primarily between fleas and mammals and is spread to humans through the bite of an infected flea or contact with afflicted animals.
Jing Geng +13 more
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The
BMC Microbiology, 2010 Background The bacterial Hfq protein is able to interact with diverse RNA molecules, including regulatory small non-coding RNAs (sRNAs), and thus it is recognized as a global post-transcriptional regulator of gene expression. Loss of Hfq has an extensive
Jiménez-Zurdo José I +7 more
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The RNA chaperone Hfq is involved in stress tolerance and virulence in uropathogenic Proteus mirabilis. [PDF]
PLoS ONE, 2014 Hfq is a bacterial RNA chaperone involved in the riboregulation of diverse genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Proteus mirabilis to effectively colonize the bladder and kidneys in a murine urinary ...
Min-Cheng Wang +4 more
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The RNA chaperone Hfq impacts growth, metabolism and production of virulence factors in Yersinia enterocolitica. [PDF]
PLoS ONE, 2014 To adapt to changes in environmental conditions, bacteria regulate their gene expression at the transcriptional but also at the post-transcriptional level, e.g. by small RNAs (sRNAs) which modulate mRNA stability and translation.
Tamara Kakoschke +6 more
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444 Post-translational role of RNA modifications in sRNA chaperone Hfq
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: The goal of this study is to determine the role of the tRNA modifications in the translation of Hfq. Hfq is an RNA chaperone that acts as a co-factor for the action of the largest class of small RNAs in E. coli.
Jalisa Nurse +2 more
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Hfq is a global regulator that controls the pathogenicity of Staphylococcus aureus. [PDF]
PLoS ONE, 2010 The Hfq protein is reported to be an RNA chaperone, which is involved in the stress response and the virulence of several pathogens. In E. coli, Hfq can mediate the interaction between some sRNAs and their target mRNAs.
Yu Liu +7 more
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eLife, 2021 RNA-binding proteins play myriad roles in regulating RNAs and RNA-mediated functions. In bacteria, the RNA chaperone Hfq is an important post-transcriptional gene regulator.
Seongjin Park +8 more
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The Conserved Dcw Gene Cluster of R. sphaeroides Is Preceded by an Uncommonly Extended 5 Leader Featuring the sRNA UpsM [PDF]
, 2016 Cell division and cell wall synthesis mechanisms are similarly conserved among bacteria. Consequently some bacterial species have comparable sets of genes organized in the dcw (division and cell wall) gene cluster.
Klug, Gabriele +5 more
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Profound impact of Hfq on nutrient acquisition, metabolism and motility in the plant pathogen Agrobacterium tumefaciens. [PDF]
PLoS ONE, 2014 As matchmaker between mRNA and sRNA interactions, the RNA chaperone Hfq plays a key role in riboregulation of many bacteria. Often, the global influence of Hfq on the transcriptome is reflected by substantially altered proteomes and pleiotropic ...
Philip Möller +6 more
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Overexpression of an outer membrane protein associated with decreased susceptibility to carbapenems in Proteus mirabilis. [PDF]
PLoS ONE, 2015 Proteus mirabilis isolates commonly have decreased susceptibility to imipenem. Previously, we found P. mirabilis hfq mutant was more resistant to imipenem and an outer membrane protein (OMP) could be involved.
Yi-Lin Tsai +6 more
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