QRB Discovery, 2022 Interactions between proteins and single-stranded DNA (ssDNA) are crucial for many fundamental biological processes, including DNA replication and genetic recombination.
Krzysztof Kubiak +10 more
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The Power Duo: How the Interplay Between Nucleoid-Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony. [PDF]
Mol MicrobiolNucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Moutacharrif S +6 more
europepmc +2 more sources
The
BMC Microbiology, 2010 Background The bacterial Hfq protein is able to interact with diverse RNA molecules, including regulatory small non-coding RNAs (sRNAs), and thus it is recognized as a global post-transcriptional regulator of gene expression. Loss of Hfq has an extensive
Jiménez-Zurdo José I +7 more
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Mechanisms and Pathological Significance of Liquid-Liquid Phase Separation in Bacteria. [PDF]
FASEB JLLPS in bacterial infections. In biological systems, the molecular mechanisms underlying LLPS are primarily driven by multivalent protein–protein interactions, protein‐nucleic acid interactions, and intramolecular interactions mediated by IDR. Through LLPS, proteins form condensates that function as ‘microfactories,’ playing crucial roles in regulating
Zhao Y +5 more
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The RNA Chaperone Hfq Is Involved in Colony Morphology, Nutrient Utilization and Oxidative and Envelope Stress Response in Vibrio alginolyticus. [PDF]
PLoS ONE, 2016 Hfq is a global regulator that is involved in environmental adaptation of bacteria and in pathogenicity. To gain insight into the role of Hfq in Vibrio alginolyticus, an hfq deletion mutant was constructed in V.
Yiqin Deng +6 more
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Polyphosphate: The "Dark Matter" of Bacterial Chromatin Structure. [PDF]
Mol MicrobiolPolyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome‐depleted nucleoid region of bacterial cells, particularly under stress (in this case Pseudomonas aeruginosa undergoing nitrogen starvation; adapted with permission from (Racki et al. 2017)). This Perspective explores the emerging view
Racki LR, Freddolino L.
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DNA Transactions in Bacteria and Membranes: A Place for the Hfq Protein? [PDF]
Membranes (Basel)Bloch S +4 more
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The RNA chaperone Hfq is involved in stress tolerance and virulence in uropathogenic Proteus mirabilis. [PDF]
PLoS ONE, 2014 Hfq is a bacterial RNA chaperone involved in the riboregulation of diverse genes via small noncoding RNAs. Here, we show that Hfq is critical for the uropathogenic Proteus mirabilis to effectively colonize the bladder and kidneys in a murine urinary ...
Min-Cheng Wang +4 more
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The RNA chaperone Hfq impacts growth, metabolism and production of virulence factors in Yersinia enterocolitica. [PDF]
PLoS ONE, 2014 To adapt to changes in environmental conditions, bacteria regulate their gene expression at the transcriptional but also at the post-transcriptional level, e.g. by small RNAs (sRNAs) which modulate mRNA stability and translation.
Tamara Kakoschke +6 more
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444 Post-translational role of RNA modifications in sRNA chaperone Hfq
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: The goal of this study is to determine the role of the tRNA modifications in the translation of Hfq. Hfq is an RNA chaperone that acts as a co-factor for the action of the largest class of small RNAs in E. coli.
Jalisa Nurse +2 more
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