Results 11 to 20 of about 4,193 (115)
Hfq: the flexible RNA matchmaker [PDF]
Current Opinion in Microbiology, 2016 The RNA chaperone protein Hfq is critical to the function of small, base pairing RNAs in many bacteria. In the past few years, structures and modeling of wild type Hfq and assays of various mutants have documented that the homohexameric Hfq ring can contact RNA at four sites (proximal face, distal face, rim and C-terminal tail) and that different RNAs ...
Taylor B Updegrove +2 more
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RNA reflections: converging on Hfq [PDF]
RNA, 2015 As the journal RNA celebrates its 20th anniversary, the role of non-coding RNAs as regulators is firmly established in a broad range of organisms. Among these are the many bacterial RNAs that pair with their targets and regulate mRNA stability and translation. In Escherichia coli and other gram-negative organisms, these small RNAs (sRNAs) depend on Hfq,
Gottesman, Susan, Storz, Gisela
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RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment [PDF]
Nature Communications, 2020 AbstractThe RNA chaperone Hfq acting as a hexamer, is a known mediator of post-transcriptional regulation expediting basepairing between small RNAs (sRNAs) and their target mRNAs. However, the intricate details associated with Hfq-RNA biogenesis are still unclear.
Pallabi Basu +5 more
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Clostridium difficile Hfq can replace Escherichia coli Hfq for most of its function [PDF]
RNA, 2014 A gene for the Hfq protein is present in the majority of sequenced bacterial genomes. Its characteristic hexameric ring-like core structure is formed by the highly conserved N-terminal regions. In contrast, the C-terminal forms an extension, which varies in length, lacks homology, and is predicted to be unstructured.
J., Caillet +3 more
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Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq [PDF]
Antibiotics, 2021 Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance for bacterial adaptation and survival in hosts.
Florian Turbant +6 more
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Hfq and its constellation of RNA [PDF]
Nature Reviews Microbiology, 2011 Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles in the control of gene expression. By facilitating the pairing of small RNAs with their target mRNAs, Hfq affects the translation and turnover rates of specific transcripts and contributes to complex post-transcriptional networks.
Jörg, Vogel, Ben F, Luisi
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Identifying and characterizing Hfq–RNA interactions [PDF]
Methods, 2013 To regulate stress responses and virulence, bacteria use small regulatory RNAs (sRNAs). These RNAs can up or down regulate target mRNAs through base pairing by influencing ribosomal access and RNA decay. A large class of these sRNAs, called trans-encoded sRNAs, requires the RNA binding protein Hfq to facilitate base pairing between the regulatory RNA ...
M A, Faner, A L, Feig
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RNA Biology, 2013 In all domains of life, non-coding RNAs (ncRNAs) play a central role in cellular biology. In bacteria, the systematic discovery and analysis of ncRNAs revealed a large repertoire of regulatory transcripts, which among other characteristics is responsible for the high adaptability of prokaryotes.
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RNA Biology, 2013 The bacterial Hfq protein is a versatile modulator of RNA function and is particularly important for regulation mediated by small non-coding RNAs. Hfq is a bacterial Sm protein but bears more similarity to the eukaryotic Sm-like (Lsm) family of proteins than the prototypical Sm proteins.
Wilusz, Carol J., Wilusz, Jeffrey
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RNA Biology, 2013 The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such as impaired stress regulation and, occasionally, loss of virulence. Hfq promotes rapid sRNA-target mRNA base pairing to allow for fast, adaptive responses.
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