Results 11 to 20 of about 11,806 (233)
Staphylococcus aureus pigmentation is not controlled by Hfq [PDF]
BMC Research Notes, 2020 Objective The golden color of Staphylococcus aureus is due to the synthesis of carotenoid pigments. In Gram-negative bacteria, Hfq is a global posttranscriptional regulator, but its function in S. aureus remains obscure. The absence of Hfq in S.
Wenfeng Liu +3 more
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Association of RNAs with Bacillus subtilis Hfq. [PDF]
PLoS ONE, 2013 The prevalence and characteristics of small regulatory RNAs (sRNAs) have not been well characterized for Bacillus subtilis, an important model system for Gram-positive bacteria. However, B.
Michael Dambach +2 more
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Impact of Hfq on the Bacillus subtilis transcriptome. [PDF]
PLoS ONE, 2014 The RNA chaperone Hfq acts as a central player in post-transcriptional gene regulation in several Gram-negative Bacteria, whereas comparatively little is known about its role in Gram-positive Bacteria.
Hermann Hämmerle +5 more
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Tracking the Elusive Function of Bacillus subtilis Hfq.
PLoS ONE, 2015 RNA-binding protein Hfq is a key component of the adaptive responses of many proteobacterial species including Escherichia coli, Salmonella enterica and Vibrio cholera.
Tatiana Rochat +6 more
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RNA binding of Hfq monomers promotes RelA-mediated hexamerization in a limiting Hfq environment [PDF]
Nature Communications, 2021 RelA stimulates RyhB small RNA–target mRNA interaction by promoting assembly of Hfq monomers into hexamers. Here the authors show that RelA-mediated Hfq hexamerization requires an initial binding of RNA to Hfq monomers.
Pallabi Basu +5 more
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RNA reflections: converging on Hfq [PDF]
RNA, 2015 As the journal RNA celebrates its 20th anniversary, the role of non-coding RNAs as regulators is firmly established in a broad range of organisms. Among these are the many bacterial RNAs that pair with their targets and regulate mRNA stability and translation. In Escherichia coli and other gram-negative organisms, these small RNAs (sRNAs) depend on Hfq,
Susan Gottesman, Gisela Storz
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Pervasive Targeting of Nascent Transcripts by Hfq
Cell Reports, 2018 Summary: Hfq is an RNA chaperone and an important post-transcriptional regulator in bacteria. Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-seq), we show that Hfq associates with hundreds of different regions of ...
Tracy K. Kambara +2 more
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Clostridium difficile Hfq can replace Escherichia coli Hfq for most of its function [PDF]
RNA, 2014 A gene for the Hfq protein is present in the majority of sequenced bacterial genomes. Its characteristic hexameric ring-like core structure is formed by the highly conserved N-terminal regions. In contrast, the C-terminal forms an extension, which varies in length, lacks homology, and is predicted to be unstructured.
J. Caillet +3 more
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Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes [PDF]
Nucleic Acids Research, 2009 Small trans-encoded RNAs (sRNAs) modulate the translation and decay of mRNAs in bacteria. In Gram-negative species, antisense regulation by trans-encoded sRNAs relies on the Sm-like protein Hfq. In contrast to this, Hfq is dispensable for sRNA-mediated riboregulation in the Gram-positive species studied thus far.
Jesper S. Nielsen +6 more
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Journal of Molecular Biology, 2012 Hfq is a bacterial RNA binding protein that facilitates small RNA-mediated posttranscriptional gene regulation. In Vibrio cholerae, Hfq and four Hfq-dependent small RNAs are essential for the expression of virulence genes, but little is known about this mechanism at the molecular level. To better understand V.
Helen A. Vincent +9 more
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