Results 21 to 30 of about 11,687 (237)

RNA reflections: converging on Hfq [PDF]

RNA, 2015
As the journal RNA celebrates its 20th anniversary, the role of non-coding RNAs as regulators is firmly established in a broad range of organisms. Among these are the many bacterial RNAs that pair with their targets and regulate mRNA stability and translation. In Escherichia coli and other gram-negative organisms, these small RNAs (sRNAs) depend on Hfq,
Gisela Storz, Susan Gottesman
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Hfq: the flexible RNA matchmaker [PDF]

Current Opinion in Microbiology, 2016
The RNA chaperone protein Hfq is critical to the function of small, base pairing RNAs in many bacteria. In the past few years, structures and modeling of wild type Hfq and assays of various mutants have documented that the homohexameric Hfq ring can contact RNA at four sites (proximal face, distal face, rim and C-terminal tail) and that different RNAs ...
Taylor B Updegrove, Aixia Zhang, Gisela Storz   +2 more
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Mechanisms and Pathological Significance of Liquid-Liquid Phase Separation in Bacteria. [PDF]

FASEB J
LLPS in bacterial infections. In biological systems, the molecular mechanisms underlying LLPS are primarily driven by multivalent protein–protein interactions, protein‐nucleic acid interactions, and intramolecular interactions mediated by IDR. Through LLPS, proteins form condensates that function as ‘microfactories,’ playing crucial roles in regulating
Zhao Y, Dai E, Zhang M, Wu Y, Sun D, Ding J.   +5 more
europepmc   +2 more sources

Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

Journal of Molecular Biology, 2012
Hfq is a bacterial RNA binding protein that facilitates small RNA-mediated posttranscriptional gene regulation. In Vibrio cholerae, Hfq and four Hfq-dependent small RNAs are essential for the expression of virulence genes, but little is known about this mechanism at the molecular level. To better understand V.
Helen A. Vincent, Charlotte A. Henderson, Timothy J. Ragan, Acely Garza-Garcı́a, Peter D. Cary, Darren M. Gowers, Marc Malfois, Paul C. Driscoll, Frank Sobott, Anastasia J. Callaghan   +9 more
openalex   +6 more sources

Hfq and its constellation of RNA [PDF]

Nature Reviews Microbiology, 2011
Hfq is an RNA-binding protein that is common to diverse bacterial lineages and has key roles in the control of gene expression. By facilitating the pairing of small RNAs with their target mRNAs, Hfq affects the translation and turnover rates of specific transcripts and contributes to complex post-transcriptional networks.
Ben F. Luisi, Jörg Vogel
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Effects of Hfq on the conformation and compaction of DNA [PDF]

Nucleic Acids Research, 2015
Hfq is a bacterial pleiotropic regulator that mediates several aspects of nucleic acids metabolism. The protein notably influences translation and turnover of cellular RNAs. Although most previous contributions concentrated on Hfq's interaction with RNA, its association to DNA has also been observed in vitro and in vivo.
Johan R. C. van der Maarel, Kai Jiang, Antoine Malabirade, Véronique Arluison, Véronique Arluison, Krzysztof Kubiak, Alain Lapp, Durgarao Guttula, Jeroen A. van Kan, Ce Zhang, Fan Liu, Christophe Lavelle   +11 more
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The RNA Chaperone Hfq Participates in Persistence to Multiple Antibiotics in the Fish Pathogen Yersinia ruckeri

Microorganisms, 2021
Yersinia ruckeri causes outbreaks of enteric redmouth disease in salmon aquaculture all over the world. The transient antibiotic tolerance exhibited by bacterial persisters is commonly thought to be responsible for outbreaks; however, the molecular ...
Iván L. Calderón, María José Barros, Fernanda Montt, Fernando Gil, Juan A. Fuentes, Lillian G. Acuña   +5 more
doaj   +1 more source

Prediction of Hfq in actinobacteria [PDF]

, 2015
AbstractHfq is the bacterial orthologue of the eukaryotic (L)Sm family of proteins found across all domains of life and potentially an ancient protein, but it has not been found in all phyletic lines. A careful search successfully identified a distant hfq orthologue in the cyanobacteria leaving the actinobacteria as the major phylum with no known hfq ...
Bora, Nagamani, Ward, Alan C, Kim, Wonyong   +2 more
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Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]

, 2013
OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes. While RprA activates rpoS for translation, OxyS
Callaghan, Anastasia, Cary, Peter, Casamento, A., Gowers, Darren, Henderson, Charlotte, Phillips, Jack, Sobott, F., Stone, Carlanne, Taylor, James E., Vincent, H.   +9 more
core   +1 more source

Cycling of RNAs on Hfq [PDF]

RNA Biology, 2013
The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such as impaired stress regulation and, occasionally, loss of virulence. Hfq promotes rapid sRNA-target mRNA base pairing to allow for fast, adaptive responses.
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