Hfq binding changes the structure of Escherichia coli small noncoding RNAs OxyS and RprA, which are involved in the riboregulation of rpoS [PDF]
, 2013 OxyS and RprA are two small noncoding RNAs (sRNAs) that modulate the expression of rpoS, encoding an alternative sigma factor that activates transcription of multiple Escherichia coli stress-response genes. While RprA activates rpoS for translation, OxyS
Callaghan, Anastasia +9 more
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Study of E. coli Hfq's RNA annealing acceleration and duplex destabilization activities using substrates with different GC-contents [PDF]
, 2012 Folding of RNA molecules into their functional three-dimensional structures is often supported by RNA chaperones, some of which can catalyse the two elementary reactions helix disruption and helix formation.
Beich-Frandsen, Mads +6 more
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Hfq Globally Binds and Destabilizes sRNAs and mRNAs in
mSystems, 2019 Hfq is a ubiquitous Sm-like RNA-binding protein in bacteria involved in physiological fitness and pathogenesis, while its in vivo binding nature remains elusive. Here we reported genome-wide Hfq-bound RNAs in Yersinia pestis, a causative agent of plague,
Yanping Han +7 more
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Solution heat treatment, forming and in-die quenching of a commercial sheet magnesium alloy into a complex-shaped component: experimentation and FE analysis [PDF]
, 2014 Interest in lightweight materials, particularly magnesium alloys, has increased significantly with rising efficiency requirements in the automotive sector.
Balint, D +8 more
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RNA Biology, 2013 The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such as impaired stress regulation and, occasionally, loss of virulence. Hfq promotes rapid sRNA-target mRNA base pairing to allow for fast, adaptive responses.
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The RNA chaperone Hfq is important for growth and stress tolerance in Francisella novicida.
PLoS ONE, 2011 The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis.
Jacob R Chambers, Kelly S Bender
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Impact of Hfq on global gene expression and intracellular survival in Brucella melitensis. [PDF]
PLoS ONE, 2013 Brucella melitensis is a facultative intracellular bacterium that replicates within macrophages. The ability of brucellae to survive and multiply in the hostile environment of host macrophages is essential to its virulence. The RNA-binding protein Hfq is
Mingquan Cui +17 more
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RNA Biology, 2013 In all domains of life, non-coding RNAs (ncRNAs) play a central role in cellular biology. In bacteria, the systematic discovery and analysis of ncRNAs revealed a large repertoire of regulatory transcripts, which among other characteristics is responsible for the high adaptability of prokaryotes.
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Effects of Hfq on the conformation and compaction of DNA [PDF]
Nucleic Acids Research, 2015 Hfq is a bacterial pleiotropic regulator that mediates several aspects of nucleic acids metabolism. The protein notably influences translation and turnover of cellular RNAs. Although most previous contributions concentrated on Hfq's interaction with RNA, its association to DNA has also been observed in vitro and in vivo.
Jiang, Kai +10 more
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mBio, 2017 Legionella pneumophila is an environmental bacterium that parasitizes protozoa, but it may also infect humans, thereby causing a severe pneumonia called Legionnaires’ disease. To cycle between the environment and a eukaryotic host, L.
Giulia Oliva +4 more
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