Results 51 to 60 of about 6,621 (215)

Hfq mutation confers increased cephalosporin resistance in Klebsiella pneumoniae [PDF]

Archives of Biological Sciences, 2017
Klebsiella pneumoniae (K. pneumoniae), is an opportunistic pathogen raising significant public health concerns owing to its multi-drug resistance. Hfq, one of the main RNA-binding proteins, is a key post-transcriptional regulator.
Li Xinran, Yang Mingjuan, Ke Yuehua, Liu Mingyuan, Wang Yufei, Liu Shiwei, Bo Liu, Chen Zeliang   +7 more
doaj   +1 more source

Functional Characterization of Acinetobacter baumannii Lacking the RNA Chaperone Hfq

Frontiers in Microbiology, 2017
The RNA chaperone Hfq is involved in the riboregulation of diverse genes via small RNAs. Recent studies have demonstrated that Hfq contributes to the stress response and the virulence of several pathogens, and the roles of Hfq vary among bacterial ...
Han-Yueh Kuo, Han-Yueh Kuo, Hsuan-Hao Chao, Po-Cheng Liao, Long Hsu, Kai-Chih Chang, Chi-Hua Tung, Chang-Hua Chen, Chang-Hua Chen, Ming-Li Liou   +9 more
doaj   +1 more source

Clostridium difficile Hfq can replace Escherichia coli Hfq for most of its function [PDF]

RNA, 2014
A gene for the Hfq protein is present in the majority of sequenced bacterial genomes. Its characteristic hexameric ring-like core structure is formed by the highly conserved N-terminal regions. In contrast, the C-terminal forms an extension, which varies in length, lacks homology, and is predicted to be unstructured.
J., Caillet, C., Gracia, F., Fontaine, E., Hajnsdorf   +3 more
openaire   +3 more sources

The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages

Nature Communications, 2022
The major RNA-binding protein Hfq interacts with mRNAs, either alone or together with regulatory small noncoding RNAs (sRNAs), affecting mRNA translation and degradation in bacteria.
Julian Trouillon, Kook Han, I. Attrée, S. Lory   +3 more
semanticscholar   +1 more source

Characterization of Vibrio cholerae Hfq Provides Novel Insights into the Role of the Hfq C-Terminal Region

Journal of Molecular Biology, 2012
Hfq is a bacterial RNA binding protein that facilitates small RNA-mediated posttranscriptional gene regulation. In Vibrio cholerae, Hfq and four Hfq-dependent small RNAs are essential for the expression of virulence genes, but little is known about this mechanism at the molecular level. To better understand V.
Vincent, H., Henderson, Charlotte, Ragan, T., Garza-Garcia, A., Cary, Peter, Gowers, Darren, Malfois, M., Driscoll, P., Sobott, F., Callaghan, Anastasia   +9 more
openaire   +4 more sources

Regulation of hierarchical carbon substrate utilization, nitrogen fixation, and root colonization by the Hfq/Crc/CrcZY genes in Pseudomonas stutzeri

iScience, 2022
Summary Bacteria of the genus Pseudomonas consume preferred carbon substrates in nearly reverse order to that of enterobacteria, and this process is controlled by RNA-binding translational repressors and regulatory ncRNA antagonists. However, their roles
Fanyang Lv, Yuhua Zhan, Wei Lu, Xiubin Ke, Yahui Shao, Yiyuan Ma, Juan Zheng, Zhimin Yang, Shanshan Jiang, Liguo Shang, Yao Ma, Lei Cheng, C. Elmerich, Yongliang Yan, Min Lin   +14 more
semanticscholar   +1 more source

Defining a role for Hfq in Gram-positive bacteria: evidence for Hfq-dependent antisense regulation in Listeria monocytogenes [PDF]

Nucleic Acids Research, 2009
Small trans-encoded RNAs (sRNAs) modulate the translation and decay of mRNAs in bacteria. In Gram-negative species, antisense regulation by trans-encoded sRNAs relies on the Sm-like protein Hfq. In contrast to this, Hfq is dispensable for sRNA-mediated riboregulation in the Gram-positive species studied thus far.
Nielsen, Jesper Sejrup, Lei, Lisbeth Kristensen, Ebersbach, Tine, Olsen, Anders Steno, Klitgaard, Janne Kudsk, Valentin-Hansen, Poul, Kallipolitis, Birgitte H.   +6 more
openaire   +2 more sources

Unraveling Membrane Perturbations Caused by the Bacterial Riboregulator Hfq

International Journal of Molecular Sciences, 2022
Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNAs. Previously, we
Florian Turbant, Jehan Waeytens, Camille Campidelli, M. Bombled, Denis Martinez, A. Grélard, Birgit Habenstein, V. Raussens, M. Vélez, F. Wien, V. Arluison   +10 more
semanticscholar   +1 more source

Identifying and characterizing Hfq–RNA interactions [PDF]

Methods, 2013
To regulate stress responses and virulence, bacteria use small regulatory RNAs (sRNAs). These RNAs can up or down regulate target mRNAs through base pairing by influencing ribosomal access and RNA decay. A large class of these sRNAs, called trans-encoded sRNAs, requires the RNA binding protein Hfq to facilitate base pairing between the regulatory RNA ...
M A, Faner, A L, Feig
openaire   +2 more sources

Dynamic refolding of OxyS sRNA by the Hfq RNA chaperone

Journal of Molecular Biology, 2022
The Sm protein Hfq chaperones small non-coding RNAs (sRNAs) in bacteria, facilitating sRNA regulation of target mRNAs. Hfq acts in part by remodeling the sRNA and mRNA structures, yet the basis for this remodeling activity is not understood.
Hua-huan Cai, Jorjethe Roca, Yu-Fen Zhao, S. Woodson   +3 more
semanticscholar   +1 more source