Results 71 to 80 of about 6,621 (215)

E. coli DNA associated with isolated Hfq interacts with Hfq's distal surface and C-terminal domain [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
The RNA-binding protein Hfq has been studied extensively for its function as a modulator of gene expression at the post-transcriptional level. While most Hfq studies have focused on the protein's interaction with sRNAs and mRNAs, Hfq binding to DNA has been observed but is less explored.
Taylor B, Updegrove, John J, Correia, Roberto, Galletto, Wlodzimierz, Bujalowski, Roger M, Wartell   +4 more
openaire   +2 more sources

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +2 more sources

Biological and transcriptomic studies reveal hfq is required for swimming, biofilm formation and stress response in Xanthomonas axonpodis pv. citri

BMC Microbiology, 2019
Background Hfq is a widely conserved bacterial RNA-binding protein which generally mediates the global regulatory activities involv ed in physiological process and virulence.
Xuelu Liu, Yuping Yan, Haodi Wu, Changyong Zhou, Xuefeng Wang   +4 more
doaj   +1 more source

Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant. [PDF]

PLoS ONE, 2014
The RNA chaperone Hfq fulfills important roles in small regulatory RNA (sRNA) function in many bacteria. Loss of Hfq in the dissimilatory metal reducing bacterium Shewanella oneidensis strain MR-1 results in slow exponential phase growth and a reduced ...
Christopher M Brennan, Nicholas Q Mazzucca, Taylor Mezoian, Taylor M Hunt, Meaghan L Keane, Jessica N Leonard, Shelby E Scola, Emma N Beer, Sarah Perdue, Brett J Pellock   +9 more
doaj   +1 more source

RNA compaction and iterative scanning for small RNA targets by the Hfq chaperone

Nature Communications
RNA-guided enzymes must quickly search a vast sequence space for their targets. This search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial small RNAs (sRNAs).
Ewelina M. Małecka, S. Woodson
semanticscholar   +1 more source

Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

eLife, 2020
By shaping gene expression profiles, small RNAs (sRNAs) enable bacteria to efficiently adapt to changes in their environment. To better understand how Escherichia coli acclimatizes to nutrient availability, we performed UV cross-linking, ligation and ...
I. Iosub, R. V. van Nues, S. McKellar, K. J. Nieken, M. Marchioretto, Brandon M. Sy, J. Tree, G. Viero, S. Granneman   +8 more
semanticscholar   +1 more source

The sRNA vvrr1 Modulates the VarS/VarA‐Csr System via LeuO to Regulate Biofilm Formation and Virulence in Vibrio alginolyticus

Animal Research and One Health, EarlyView.
vvrr1, a small RNA, post‐transcriptionally represses the transcriptional regulator LeuO, which directly inhibits the VarS/VarA two‐component system. This triggers a Csr cascade that relieves LuxO repression, ultimately modulating exopolysaccharide production to control biofilm formation and virulence in Vibrio alginolyticus.
Theerakamol Pengsakul, Lei Wen, Lingmin Zhao, Bei Huang, Jiang Zheng, Binfu Xu, Lixing Huang   +6 more
wiley   +1 more source

Sm‐like protein Hfq: Location of the ATP‐binding site and the effect of ATP on Hfq–RNA complexes [PDF]

Protein Science, 2007
AbstractSm‐like proteins are ubiquitous ring‐shaped oligomers that exhibit a variety of nucleic acid‐binding activities. They have been linked functionally to various cellular events involving RNA, and it is generally believed that their activity is exerted via the passive binding of nucleic acids.
Arluison, Veronique, Mutyam, Shravan, Mura, Cameron, Marco, Sergio, Sukhodolets, Maxim   +4 more
openaire   +3 more sources

Serotypic and Genomic Diversity of Vibrio anguillarum in Rainbow Trout Farms in Turkey: Implications for Vibriosis Control and Vaccine Candidate Selection

Journal of Fish Diseases, EarlyView.
ABSTRACT Outbreaks of vibriosis caused by Vibrio anguillarum are a persistent constraint on rainbow trout (Oncorhynchus mykiss) aquaculture. However, information on the population structure of field strains in Turkey has been lacking. Here, we report the first systematic serotypic, proteomic, and genomic characterization of 23 V.
Soner Altun, Muhammed Duman, Jesús L. Romalde, Nihed Ajmi, Gorkem Tasci, Cuneyt Ozakin, Nazmiye Ulku Tuzemen, Bekir Akça, Sebahattin Ergün, Sevdan Yılmaz, Izzet Burcin Saticioglu   +10 more
wiley   +1 more source

Shewanella oneidensis Hfq promotes exponential phase growth, stationary phase culture density, and cell survival

BMC Microbiology, 2013
Background Hfq is an RNA chaperone protein that has been broadly implicated in sRNA function in bacteria. Here we describe the construction and characterization of a null allele of the gene that encodes the RNA chaperone Hfq in Shewanella oneidensis ...
Brennan Christopher M, Keane Meghan L, Hunt Taylor M, Goulet Matthew T, Mazzucca Nicholas Q, Sexton Zachary, Mezoian Taylor, Douglas Katherine E, Osborn Jessica M, Pellock Brett J   +9 more
doaj   +1 more source