Results 41 to 50 of about 11,687 (237)

Hfq stimulates the activity of the CCA-adding enzyme [PDF]

BMC Molecular Biology, 2007
Abstract Background The bacterial Sm-like protein Hfq is known as an important regulator involved in many reactions of RNA metabolism. A prominent function of Hfq is the stimulation of RNA polyadenylation catalyzed by E. coli poly(A) polymerase I (PAP).
Scheibe, M., Bonin, S., Hajnsdorf, E., Betat, H., Mörl, M.   +4 more
openaire   +4 more sources

Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq [PDF]

Antibiotics, 2021
Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance for bacterial adaptation and survival in hosts.
Frank Wien, Florian Turbant, Théa Legoubey, David Partouche, Omar El Hamoui, Véronique Arluison, Véronique Arluison, Sylvain Trépout   +7 more
openaire   +4 more sources

Polyphosphate: The "Dark Matter" of Bacterial Chromatin Structure. [PDF]

Mol Microbiol
Polyphosphate condensates and their contributions to nucleoid structure. Polyphosphate condensates form in the ribosome‐depleted nucleoid region of bacterial cells, particularly under stress (in this case Pseudomonas aeruginosa undergoing nitrogen starvation; adapted with permission from (Racki et al. 2017)). This Perspective explores the emerging view
Racki LR, Freddolino L.
europepmc   +2 more sources

Extracellular Vesicles From Xylella fastidiosa Carry sRNAs and Genomic Islands, Suggesting Roles in Recipient Cells. [PDF]

J Extracell Vesicles
ABSTRACT Xylella fastidiosa (Xf) is a Gram‐negative bacterial plant pathogen responsible for severe diseases in a variety of economically important crops. A critical aspect of its virulence is the production of extracellular vesicles (EVs). In this study, we discovered that DNA‐binding proteins and nonribosomal RNA‐binding proteins are abundant in the ...
Ruf A, Blumenkamp P, Ludwig C, Lippegaus A, Brachmann A, Klingl A, Goesmann A, Brinkrolf K, Papenfort K, Robatzek S.   +9 more
europepmc   +2 more sources

The Hfq regulon of Neisseria meningitidis

FEBS Open Bio, 2017
The conserved RNA‐binding protein, Hfq, has multiple regulatory roles within the prokaryotic cell, including promoting stable duplex formation between small RNAs and mRNAs, and thus hfq deletion mutants have pleiotropic phenotypes. Previous proteome and transcriptome studies of Neisseria meningitidis have generated limited insight into differential ...
Robert A. G. Huis in ‘t Veld, Gertjan Kramer, Arie van der Ende, Dave Speijer, Yvonne Pannekoek   +4 more
openaire   +3 more sources

Hfq mutation confers increased cephalosporin resistance in Klebsiella pneumoniae [PDF]

Archives of Biological Sciences, 2017
Klebsiella pneumoniae (K. pneumoniae), is an opportunistic pathogen raising significant public health concerns owing to its multi-drug resistance. Hfq, one of the main RNA-binding proteins, is a key post-transcriptional regulator.
Li Xinran, Yang Mingjuan, Ke Yuehua, Liu Mingyuan, Wang Yufei, Liu Shiwei, Bo Liu, Chen Zeliang   +7 more
doaj   +1 more source

Functional Characterization of Acinetobacter baumannii Lacking the RNA Chaperone Hfq

Frontiers in Microbiology, 2017
The RNA chaperone Hfq is involved in the riboregulation of diverse genes via small RNAs. Recent studies have demonstrated that Hfq contributes to the stress response and the virulence of several pathogens, and the roles of Hfq vary among bacterial ...
Han-Yueh Kuo, Han-Yueh Kuo, Hsuan-Hao Chao, Po-Cheng Liao, Long Hsu, Kai-Chih Chang, Chi-Hua Tung, Chang-Hua Chen, Chang-Hua Chen, Ming-Li Liou   +9 more
doaj   +1 more source

Post-transcriptional regulator Hfq binds catalase HPII: crystal structure of the complex. [PDF]

PLoS ONE, 2013
We report a crystal structure of Hfq and catalase HPII from Escherichia coli. The post-transcriptional regulator Hfq plays a key role in the survival of bacteria under stress.
Koji Yonekura, Masahiro Watanabe, Yuko Kageyama, Kunio Hirata, Masaki Yamamoto, Saori Maki-Yonekura   +5 more
doaj   +1 more source

Models of Hfq interactions with small non-coding RNA in Gram-negative and Gram-positive bacteria

Frontiers in Cellular and Infection Microbiology, 2023
Hfq is required by many Gram-negative bacteria to chaperone the interaction between small non-coding RNA (sRNA) and mRNA to facilitate annealing. Conversely and despite the presence of Hfq in many Gram-positive bacteria, sRNAs in Gram-positive bacteria ...
Derrick Watkins, Dev Arya
doaj   +1 more source

Discovery Of Ethanol-Responsive Small Rnas In Zymomonas Mobilis [PDF]

, 2014
Zymomonas mobilis is a bacterium that can produce ethanol by fermentation. Due to its unique metabolism and efficient ethanol production, Z. mobilis has attracted special interest for biofuel energy applications; an important area of study is the ...
Cho, Seung Hee, Contreras, Lydia M., Henninger, Trey D., Lei, Roy   +3 more
core   +1 more source