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Glycoproteins of HHV-6A and HHV-6B
2018Recently, human herpesvirus 6A and 6B (HHV-6A and HHV-6B) were classified into distinct species. Although these two viruses share many similarities, cell tropism is one of their striking differences, which is partially because of the difference in their entry machinery.
Huamin, Tang, Yasuko, Mori
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HHV-6A infection induces expression of HERV-K18-encoded superantigen
Journal of Clinical Virology, 2009The human endogenous retrovirus K-18 (HERV-K18) encodes a superantigen that causes deregulation of the immune system. This provirus is transcriptionally silent, but can be induced by Epstein-Barr virus (EBV) infection and IFN-alpha treatment.Since the herpesvirus EBV induces HERV-K18 expression in human B cells, it was of interest to determine if other
Albert K, Tai +3 more
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MHC2TA rs4774C and HHV‐6A active replication in multiple sclerosis patients
European Journal of Neurology, 2009Background and purpose: In a previous report, a strong gene–environment interaction between human herpesvirus 6A (HHV6A) active replication and MHC2TA rs4774C was demonstrated. The objectives of this study were: (i) to reappraise the association that was found in the previous study; (ii) to evaluate if MS patients with minor allele C and HHV‐6A active
R, Alvarez-Lafuente +11 more
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PCR Analysis of Human Telomeric Repeats Present on HHV-6A Viral Strains
Virus Genes, 1997Human herpesvirus 6 (HHV-6) presents a perfect tandem array of human telomeric repeats (TRS) at both identical direct repeats (DR). Several researchers have reported a different TRS copy number by sequence analysis of HHV-6 DR's cloned fragments so it has been hypothesized that number of TRS is unstable. By PCR we show that the TRS copy number of U1102
MIRANDOLA, Prisco +2 more
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HHV-6A and HHV-6B in Autoimmune Disease
2014A role for HHV-6 has been proposed in several autoimmune disorders (ADs), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. There are several potential mechanisms by which HHV-6 might induce autoimmune responses.
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AMPK restricts HHV-6A replication by inhibiting glycolysis and mTOR signaling
VirologyAMP-activated protein kinase (AMPK) is a cellular energy sensor regulating metabolic homeostasis. In this study, we investigated the role of AMPK in response to human herpesvirus 6A (HHV-6A) infection. We show that HHV-6A infection significantly downregulates the active phosphorylated state of AMPK in infected T cells.
Xiaodi, Yang +7 more
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HHV-6A, 6B, and 7: pathogenesis, host response, and clinical disease
2007Human herpesvirus 6(HHV-6) is a human pathogen of emerging clinical significance. HHV-6 was first isolated from patients with lymphoproliferative disorders in 1986 (Salahuddin et al., 1986). HHV-6 isolates are classified into two groups as variants A(HHV-6A) and variant B(HHV-6B) (Schirmer et al., .
Yasuko Mori, Koichi Yamanishi
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HHV-6A, 6B, and 7: molecular basis of latency and reactivation
2007The human β-herpesvirus subfamily consists of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), and human herpesvirus 7 (HHV-7). HHV-6 and HHV-7 belong to the Roseolovirus genus of the β-herpesviruses, and the HHV-6 species are divided into two variants: HHV-6A and HHV-6B.
Kazuhiro Kondo, Koichi Yamanishi
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