Results 121 to 130 of about 78,725 (202)

Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition.

PLoS Pathogens
Human herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary mediator of membrane fusion during viral entry, is a key
Chu Xie, Xin-Yan Fang, Yuan-Tao Liu, Xian-Shu Tian, Lan-Yi Zhong, Pei-Huang Wu, Hang Zhou, Peng-Lin Li, Yan-Lin Yang, Zi-Ying Jiang, Sen-Fang Sui, Zheng Liu, Mu-Sheng Zeng, Cong Sun   +13 more
doaj   +1 more source

LYMPHOPROLIFERATIVE SYNDROMES ASSOCIATED WITH HUMAN HERPESVIRUS-6A AND HUMAN HERPESVIRUS-6B

Mediterranean Journal of Hematology and Infectious Diseases, 2018
Human herpesvirus 6A and 6B (HHV-6A and HHV-6B) have been noted since their discovery for their T-lymphotropism. Although it has proven difficult to determine the extent to which HHV-6A and HHV-6B are involved in the pathogenesis of many diseases ...
Eva Eliassen, Gerhard R Krueger, Mario Luppi, Dharam Ablashi   +3 more
doaj   +1 more source

Analyses of germline, chromosomally integrated human herpesvirus 6A and B genomes indicate emergent infection and new inflammatory mediators.

, 2014
Human herpesvirus-6A (HHV-6A) is rarer than HHV-6B in many infant populations. However, they are similarly prevalent as germline, chromosomally integrated genomes (ciHHV-6A/B).
Spyrou, MA, Hubacek, P, Lassner, D, Kuhl, U, Gompels, UA, Tweedy, J   +5 more
core   +1 more source

Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production

Journal of Virology
Human herpesvirus 6B (HHV-6B), a member of the Betaherpesvirinae subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis.
Haokun Li, Hirohito Ogawa, Da Teng, Yuki Okame, Hikaru Namba, Tomoyuki Honda   +5 more
doaj   +1 more source

GP96 interacts with HHV-6 during viral entry and directs it for cellular degradation.

PLoS ONE, 2014
CD46 and CD134 mediate attachment of Human Herpesvirus 6A (HHV-6A) and HHV-6B to host cell, respectively. But many cell types interfere with viral infection through rapid degradation of viral DNA.
Bhupesh K Prusty, Christine Siegl, Nitish Gulve, Yasuko Mori, Thomas Rudel   +4 more
doaj   +1 more source

Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation

Haematologica, 2019
Of the two human herpesvirus 6 (HHV-6) species, human herpesvirus 6B (HHV-6B) encephalitis is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant. Guidelines for the management of HHV-6 infections in patients
Katherine N Ward, Joshua A Hill, Petr Hubacek, Rafael de la Camara, Roberto Crocchiolo, Hermann Einsele, David Navarro, Christine Robin, Catherine Cordonnier, Per Ljungman   +9 more
doaj   +1 more source

HHV-6B binds to the sperm head.

, 2013
Semen samples were incubated with HHV-6B for two hrs, washed twice in PBS and stained with anti-gp60/110 or anti-IgG2b followed by a goat-anti mouse (GaM)-FITC. (A-B) and (E-K) HHV-6B binds specifically to the front region of the sperm head.
Peter B. Larsen (299888), Jens Fedder (4716), Emil Kofod-Olsen (299890), Jesper Bonde (299892), Maja D. Kaspersen (299887), Per Höllsberg (299893)   +5 more
core   +1 more source

Prevalence of human herpesvirus 6A and 6B during pregnancy [PDF]

, 2014
The aim of the present study was to assess the frequency of human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B) infection during pregnancy.
Gergely, Lajos, Mészáros, Beáta, Csoma, Eszter, Sápy, Tamás, Lajos Gergely, Eszter Csoma, Beáta Mészáros, Tamás Sápy   +7 more
core   +1 more source

Probing the interactions between U24 from HHV-6B and hNedd4L WW and Fyn-SH3 domains

, 2022
Multiple sclerosis (MS) is neurological inflammatory disease in the central nervous system (CNS) that affects every 1 in 400 people in Canada. Although it was first characterized over a century ago, the cause of MS remains elusive, as does consequently a
Pi, Keng-Shuo
core   +1 more source

HHV-6A in syncytial giant-cell hepatitis

, 2008
Syncytial giant-cell hepatitis is a rare but severe form of hepatitis that is associated with autoimmune diseases, drug reactions, and viral infections. We used serologic, molecular, and immunohistochemical methods to search for an infectious cause in a ...
LUPPI, Mario, Pecorari, Monica, DI BENEDETTO, Fabrizio, M. Codeluppi, Gennari, William, P. Barozzi, Landini, Maria Paola, PORTOLANI, Marinella, M. Masetti, G. Rossi, M. Pecorari, ROSSI, Giulio, M. Luppi, BAROZZI, Patrizia, GUARALDI, Giovanni, COCCHI, Stefania, MASETTI, Michele, F. Di Benedetto, L. Potenza, G. E. Gerunda, TORELLI, Giuseppe, W. Gennari, Schulz, Thomas F., Codeluppi, Mauro, T. F. Schulz, GERUNDA, Giorgio Enrico, G. Torelli, LAZZAROTTO, TIZIANA, G. Guaraldi, S. Cocchi, M. Portolani, POTENZA, Leonardo   +31 more
core   +1 more source