Results 281 to 290 of about 19,695,084 (324)

Application of interspecies scaling to the bispyridinium oxime HI-6

American Journal of Veterinary Research, 1994
Summary Disposition kinetic variables of HI-6, a bispyridinium oxime, have been determined in mice, rats, rabbits, Rhesus monkeys, Beagles, sheep, and human beings. The drug has a short half-life, small apparent volume of distribution and high body clearance in these species, and is eliminated mainly by renal excretion.
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Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys

Toxicology and Applied Pharmacology, 1992
The therapeutic efficacy of the oxime HI-6 against intoxication with the irreversible cholinesterase (ChE) inhibitor soman was tested in marmoset monkeys. Five out of six marmosets, intoxicated with 5 x LD50 soman and treated immediately with diazepam (0.2 mg.kg-1 iv) and 15 sec later with atropine (0.5 mg.kg-1 im) and HI-6 (50 mg.kg-1 im), survived ...
H P, van Helden, H J, van der Wiel, J, de Lange, R W, Busker, B P, Melchers, O L, Wolthuis   +5 more
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Neurobehavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6

Neurotoxicology and Teratology, 1990
A series of neurobehavioral testing procedures was used to evaluate the behavioral effects of the pyridinium aldoxime cholinesterase reactivator HI-6 in male Sprague-Dawley rats. These procedures were fixed-ratio (FR) responding, shuttle-box conditioned avoidance response (CAR), conditioned taste aversion (CTA), drinking behavior, open-field ...
W F, Liu, J H, Shih
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Cholinergic Effects of HI-6 in Soman Poisoning

1986
During the past decade considerable advances have been made in the development of therapeutic antidotes against organophosphorus cholinesterase (ChE) inhibitors. Poisoning with most organophosphorus anticholinesterases (AntiChE) is treatable with a combination of an antimuscarinic compound, such as atropine sulfate (ATS), and an oxime, such as ...
T.-M. Shih, C. E. Whalley, J. J. Valdes, P. M. Lundy, P. A. Lockwood   +4 more
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A preformulation study on the kinetics of HI-6 in concentrated solution

International Journal of Pharmaceutics, 1987
Abstract The degradation kinetics of HI-6 have been investigated at various temperatures and at different pHs at a concentration of 200 mg/ml. Both aqueous and other hydrophilic solvents (glycols and glycerol-water mixtures) have been used. The degradation of HI-6 follows pseudo-first-order kinetics with respect to HI-6.
P FYHR, M NICKLASSON, K GUNNVALD, A BRODIN   +3 more
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Histopathological Changes in Gastrocnemius Muscles of Rabbits Injected with HI-6 in Saline

Drug and Chemical Toxicology, 1990
The gastrocnemius muscles of rabbits were injected with HI-6 in saline. Macroscopic and histopathological examinations of injection sites and regional lymph nodes revealed that HI-6 in saline produced muscle necrosis. Macroscopic examinations of muscles injected with a low dose of HI-6 (50 mg/kg) showed no lesions on Day 7.
C E, Connolley-Mendoza, T, Bhatti, K, Jericho   +2 more
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Pharmacokinetics of the Oxime HI‐6 from a Mixture with Atropine Sulphate in Dogs

Pharmacology & Toxicology, 1992
Abstract: The pharmacokinetics of the oxime HI‐6 from an aqueous solution and from a mixture containing HI‐6 and atropine (in doses similar as proposed for their combination in an automatic injector) was studied in German shepherd dogs. A standard manual injection of mixed drugs was followed by enhanced resorption of HI‐6 while the elimination curves ...
D, Jovanović, V, Kovacević, M, Maksimović   +2 more
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A High-Performance Liquid Chromatographic Assay for HI-6 Oxime in Plasma*

Journal of Analytical Toxicology, 1990
A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 (1-(2-hydroxyiminomethyl-1-pyridinio-3-(4-carbamoyl-1-py ridiniol-2-oxapropane dichloride)) concentrations in small volumes of plasma. A 100-microL plasma sample added to 900 microL of distilled water was microfiltered. Filtrate (200 microL) was injected onto an HPLC
M P, McCluskey, C R, Clark, B G, Talbot, M D, Green, B J, Lukey   +4 more
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In vivo distribution of organophosphate antidotes: Autoradiography of [14C]HI-6 in the rat

Toxicology and Applied Pharmacology, 1988
In order to visualize the distribution of HI-6 in the rat after iv administration, autoradiographic experiments were carried out with [14C]HI-6, labeled at the carbon of the carboxamide moiety. Autoradiography clearly confirms penetration of HI-6 into the central nervous system.
Ligtenstein, D.A., Moes, G.W.H., Kossen, S.P.   +2 more
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Trimedoxime and HI‐6: Kinetic Comparison after Intravenous Administration to Mice

Pharmacology & Toxicology, 1996
Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B, Milic, M, Maksimovic, M, Nedelijkovic
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